本团队专注于糖尿病相关的下肢血管病变、周围神经病变以及糖尿病足的基础与临床研究，拥有一支由多位临床技术骨干和科研人员组成的专业团队。团队成员不仅在临床实践中积累了丰富的经验，还具备强大的科研能力，能够为研究生的临床与科研工作提供全面的指导和支持。目前团队承担并积极开展多项国家级及市级科研课题，研究成果已发表于《Advanced Science》《Advanced Healthcare Materials》等国际顶尖SCI期刊。

1. 国家自然科学基金（面上），2021.01-2024.12，编号：8207070257，ORSH移植体系改善干细胞微环境及其对缺血性下肢血管病疗效的研究

2. 国家自然科学基金（面上），2016.01-2019.12，编号：81570738，胎盘干细胞调控巨噬细胞极性改善缺血性下肢血管病的机制研究

3.国家自然科学基金（青年），2013.01-2015.12，编号：8120024，胎盘干细胞治疗下肢缺血的疗效及机制研究

4.中央高校交叉类课题，2015.09-2016.09，编号:1508219073，一种可以显著提高干细胞心肌梗死疗效的移植体系研究

4. 上海市自然科学基金，2013.01-2015.12，编号：12ZR1428400，micRNA126调控内皮足细胞旁分泌的机制研究

5. 中国博士后科学基金面上项目，2010.11-2011.11，编号：20100480640，脐带间充质干细胞治疗糖尿病下肢血管病的免疫机制研究

主持科研项目

1. 国家自然科学基金（面上），2021.01-2024.12，编号：8207070257，ORSH移植体系改善干细胞微环境及其对缺血性下肢血管病疗效的研究

2. 国家自然科学基金（面上），2016.01-2019.12，编号：81570738，胎盘干细胞调控巨噬细胞极性改善缺血性下肢血管病的机制研究

3.国家自然科学基金（青年），2013.01-2015.12，编号：8120024，胎盘干细胞治疗下肢缺血的疗效及机制研究

4.中央高校交叉类课题，2015.09-2016.09，编号:1508219073，一种可以显著提高干细胞心肌梗死疗效的移植体系研究

4. 上海市自然科学基金，2013.01-2015.12，编号：12ZR1428400，micRNA126调控内皮足细胞旁分泌的机制研究

5. 中国博士后科学基金面上项目，2010.11-2011.11，编号：20100480640，脐带间充质干细胞治疗糖尿病下肢血管病的免疫机制研究

SCI论文（第一作者或通讯作者25篇）

1.    Zhao Z, Zhang Y, Meng C, Xie X,Cui W, Zuo K. Tissue-Penetrating Ultrasound-Triggered Hydrogel for PromotingMicrovascular Network Reconstruction. Adv Sci (Weinh). 2024Jun;11(23):e2401368. (IF: 14.3共同通讯)

2.    Wu Y, Dong D, Zhu L, Luo Z, LiuY, Xie X. Interpretable machine learning models for detecting peripheralneuropathy and lower extremity arterial disease in diabetics: an analysis ofcritical shared and unique risk factors. BMC Med Inform Decis Mak. 2024 Jul22;24(1):200. (IF: 3.3通讯作者)

3.    Fan W, Zhou M, Zheng S, Liu Y,Pan S, Guo P, Xu M, Hu C, Ding A, Wang Z, Yin S, Zuo K, Xie X. Human umbilicalcord mesenchymal stem cell-derived exosomes promote microcirculation in ageddiabetic mice by TGF-β1 signaling pathway. DiabetolMetab Syndr. 2023 Nov 15;15(1):234. (IF: 3.4共同通讯)

4.    Yangyi Sheng, Qian Ren, ChengTao, Mei Wen, Pu Qu,Nuo Yu, Maoquan Li*, XiaoyunXie*. Construction of PEGylatedChlorin e6@CuS-Pt theranostic nanoplatforms fornanozymes-enhancedphotodynamic-photothermal therapy. J Colloid Interface Sci2023; 645:122-32. (IF: 9.965 共同通讯)

5.    Zixuan Zhou, Weizhong Yuan*,Xiaoyun Xie*. A stretchable andadhesive composite hydrogel containing PEDOT:PSS for wide-range and precisemotion sensing and electromagnetic interferenceshielding and as atriboelectric nanogenerator Mater. Chem. Front.2022, 6, 3359.(IF: 8.683共同通讯)

6.    Xi Zhang, Yuting Wang, YiboWang, Yamei Guo*, Xiaoyun Xie*, Yifu Yu*, Bin Zhang. Recentadvances inelectrocatalytic nitrite reduction. Chem Commun (Camb) 2022;58(17): 2777-87.(IF: 6.065 共同通讯)

7.    Songsong Pan, Sushant S. Hada,Yang Liu, Chao Hu, Mengdie Zhou, ShaoqiuZheng, Minjie Xu, Changsheng Shi, ShiwuYin*, Xiaoyun Xie*. HumanPlacenta-Derived Mesenchymal Stem Cells AmeliorateDiabetic Neuropathy via WntSignaling Pathway. Stem Cells Int, 2022 Sep 6;2022:6897056.（IF: 5.1 共同通讯）

8.    Xiaodie Ma, Chunyao Wang,Weizhong Yuan*, Xiaoyun Xie*, YeSong*. Highly Adhesive, Conductive, andSelf-Healing Hydrogel with TripleCross-Linking Inspired by Mussel and DNA forWound Adhesion and Human MotionSensing. ACS Applied Polymer Materials, 2021, 3,6586-6597（IF: 4.8 共同通讯）

9.    Zixuan Zhou, Zhirui He, ShiwuYin*, Xiaoyun Xie*, WeizhongYuan*. Adhesive, stretchable and antibacterialhydrogel withexternal/self-power for flexible sensitive sensor used as humanmotiondetection. Composites Part B-Engineering, 2021,220,108984.1-108984.（IF: 11.322共同通讯）

10.  Wu Danfeng, Xu Zhangting, LiZhihong, Yuan Weizhong*, Wang Hai-Quan*, XiaoyunXie*, Reduction and temperaturedually-triggered size-shrinkage anddrug release of micelles for synergisticphotothermal-chemotherapy of cancer, EuropeanPolymer Journal, 2021, 154.（IF: 5.546 共同通讯）

11.  Chunyao Wang, Chenyu Liang, RuiWang, Xueliang Yao, Peng Guo, WeizhongYuan, Yang Liu, Ye Song*, Zhihong Li* andXiaoyun Xie*. Thefabrication of a highly efficient self-healing hydrogel fromnaturalbiopolymers loaded with exosomes for the synergistic promotion of severewoundhealing. Biomaterials Science, 2020, 8, 313.（IF:7.59 共同通讯）

12.  Rui Wang, Xueliang Yao, TingyuLi, Xue Li, MingmingJin, Yebin Ni, Weizhong Yuan*, Xiaoyun Xie*, Ligong Lu*,MaoquanLi*. ReversibleThermoresponsive Hydrogel Fabricated from NaturalBiopolymer for theImprovement of Critical Limb Ischemia by Controlling Releaseof Stem Cells. AdvancedHealthcare Materials, 2019, 8(18)（IF: 11.092 共同通讯）

13.  Yi Shen, Zhangting Xu, LulinLi, Weizhong Yuan*,Ming Luo*, Xiaoyun Xie*. Fabrication of glucose-responsiveandbiodegradable copolymer membrane for controlled release of insulinatphysiological pH. New J. Chem., 2019, 43, 7822.（IF:3.925 共同通讯）

14.  Xiangnan Chen, Weizhong Yuan*,Miao Jiang*, XiaoyunXie*. Surface glycopolymer-modified functional macroporouspolyHIPEobtained by ATRP for the removal of boron in water. New Journal ofChemistry,2018.2.7, 42(3): 2104-2112.（IF: 3.925 共同通讯）

15.  Yi Shen, Yang Liu, ShaoqiuZheng, Jiang Han, ErliPei, Zhihong Li, Xiaoyun Xie*, Zhiqiang Li*, Ming Luo*.Effectsof Left Gastric Artery Ligation Versus Sleeve Gastrectomy onObesity-InducedAdipose Tissue Macrophage Infiltration and Inflammation inDiet-Induced ObeseRats. Med Sci Monit. 2019; 25:6719-6726. (IF: 3.386 共同通讯)

16.  Yang Liu, Lianyu Chen, Yi Shen,Tao Tan, Nanzi Xie,Ming Luo*, Zhihong Li*, Xiaoyun Xie*. CurcuminAmelioratesIschemia Induced Limb Injury through Immunomodulation. Med SciMonit. 2016;22: 2035–2042.（IF:3.386 共同通讯）

17.  Bo Zhang, Timothy M Adesanyac,Li Zhang, Nanzi Xie,Zhishui Chen, Minhuang Fu, Jie Zhang, Jian Zhang, Tao Tan,Ahemt Kilicc,Zhihong Li*, Hua Zhu*, Xiaoyun Xie*. Delivery ofPlacenta-DerivedMesenchymal Stem Cells Ameliorates Ischemia InducedLimb InjurybyImmunomodulation. Cell Physiol Biochem. 2014;34(6):1998-2006.（IF: 3.550 共同通讯）

18.  Weixin Guo#, Zhihong Li#,XiaoyunXie#, Tao Tan, Shouhong Wang, Nanzi Xie, Minghuan Fu, HuaZhu, Tiehe Qin.Stromal cell-derived factor-1α attenuatesoleate-induced acutelung injury in rabbits. Biochemical and biophysicalresearch communications. BiochemBiophys Res Commun. 2014 12;452(1):191-6.（IF: 3.322 共同第一）

19.  Nanzi Xie, Zhihong Li, TimothyM Adesanya, WeixinGuo, Yang Liu , Minghuan Fu, Ahmet Kilic c, Tao Tan, Hua Zhu,Xiaoyun Xie*.Transplantation of placenta-derived mesenchymal stem cellsenhancesangiogenesis after ischemic limb injury in mice. Journal of CellularandMolecular Medicine. 2016, 20 (1) :29-37（IF: 5.295 通讯作者）

20.  Weixin Guo#, Zhihong Li#,XiaoyunXie#, Tiehe Qin, Yan Wu. Urinary Trypsin InhibitorAttenuates Acute LungInjury by Improving Endothelial Progenitor CellsFunctions. Cell PhysiolBiochem. 2015;36(3):1059-68.（IF: 3.550 共同第一）

21.  Minghuan Fu, Zhihong Li, TaoTan, Weixin Guo, NanziXie, Qing Liu, Hua Zhu*, Xiaoyun Xie*, Han Lei*.Akt/eNOSsignaling pathway mediates inhibition of endothelial progenitor cellsbypalmitate-induced ceramide. Am J Physiol Heart Circ Physiol. 2015;308(1):H11-7.（IF: 5.125 共同通讯）

22.  Poren Kong#, Xiaoyun Xie#,FangLi, Yang Liu, Yingli Lu. Placenta mesenchymal stem cell accelerateswoundhealing by enhancing angiogenesis in diabetic Goto-Kakizaki (GK) rats.Biochemical andBiophysical Research Communications. 2013 Aug 23;438(2):410-9.（IF: 3.322 共同第一）

23.  Xiaoyun Xie#, Poren Kong.Curcumin attenuates lipolysis stimulated by tumor necrosisfactor-α or isoproterenol in 3T3-L1 adipocytes.Phytomedicine.2012,15;20(1):3-8.（IF: 6.656 第一作者）

24.  Xiaoyun Xie#, Zhaohui Mo, KeChen, HongHui He, YanHong Xie. Glucagon-like Peptide-1Improve Proliferation andDifferentiation of Endothelial Progenitor Cells viaUpregulating VEGFGeneration. Med Sci Monit, 2011; 17(2): BR35-41.（第一作者IF: 3.386）

25.  Xiaoyun Xie#, Zhuoxiong Chen,Minxiang Lei, Xingxuan He, Schuchman Edward H. Feng Liu,Song Xuhan, Hua Linan.Ceramide mediates inhibition of the AKT/eNOS signalingpathway by palmitate inhuman vascular endothelial cells. Medical ScienceMonitor, 2009,15(9):BR254-261.（第一作者 IF: 3.386）