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曲 伸，医学博士，留美博士后，上海市领军人才，医学领军人才，浦江人才。现任同济大学医学院甲状腺疾病研究所和同济大学医学院肥胖症研究所所长，同济大学附属第十人民医院肥胖症诊治中心主任，上海曜影医疗内分泌代谢及甲状腺中心主任、主任医师，同济大学医学院内科学教授、博士生导师，南京医科大学、安徽医科大学教授，中华医学会内分泌分会常委、肝病与代谢学组组长，中华预防医学会糖尿病预防与控制专业委员会常委，上海市内分泌学会顾问，上海内分泌医师协会副会长。独创了肥胖诊治的辨色诊治和个体化诊疗的理论，牵头撰写国内首部肥胖多学科诊疗共识《基于临床的肥胖症多学科诊疗共识（2021版）》及《肥胖患者的长期体重管理及药物临床应用指南（2024 版）》，得到业内专家的广泛认可。目前以第一作者及通讯作者发表JCI、Protein Cell 、JCEM、JBC、Obesity Surgery 等SCI论文100余篇，核心期刊100余篇，著书10余部，包括《肥胖症》（人民卫生出版社出版）及《肥胖的基础与临床实践》（已获得同济大学出版基金），承担并完成国内外基金30余项，其中国家级课题7项，获军内科技进步奖4项，以第一完成人获得中华医学科技三等奖（202103267）、华夏医学科技奖三等奖（2020LC0116P1）、教育部自然科学二等奖（2013-062），上海市自然科学三等奖（2011030201）各一项。2013年被评为上海市卫生局《东方名院名医录》收录名医。
1.国家自然科学基金面上项目（82170861），基于代谢的人工智能辅助肥胖症临床分型的脑功能学研究，80万
2.申康三年行动计划重大临床项目（SHDC2020CR6003-003）上海市甲状腺癌特色专病队列数据库的建设和应用，子课题负责人，30万
3.申康三年行动计划重大临床项目（SHDC2020CR1017B），SADI-S治疗病态肥胖的多中心随机对照临床研究,子课题负责人，90万
4.上海市科委，贝那鲁肽注射液治疗超重/肥胖适应症Ⅲ期临床研究，19DZ1910200，48万
5.国家自然科学基金面上项目（81970677）选择性阻断中枢FoxO1干预下丘脑炎症改善肥胖的机制研究，53万
6.同济大学“中央高校基本科研业务费专项资金”（22120190210）基于代谢和脑fMRI影像学的人工智能辅助肥胖症亚型的鉴别诊断和胃减容术的疗效预测，60万
7.上海交通大学医学院附属瑞金医院（DLY201801） 中国成人2型糖尿病降压治疗目标研究，分课题负责人，6万
8.科技部，2型糖尿病智能优化综合管理体系和社会经济效益评价， 100万
9.上海市科委，2型糖尿病合并高血压患者血压控制目标多中心临床研究与肾脏并发症（18411951803）,30万
10.上海市科委，贝那鲁肽注射液治疗二甲双胍单药血糖控制不佳的2型糖尿病患者研究（17DZ1910603）,36万
11.国家科技部重点研发计划重大慢性非传染性疾病防控研究重点专项子课题 创建2型糖尿病与糖尿病高风险早期筛查指标体系与早期识别技术体系(2016YFC1305600)，15万
12.上海市人力资源保障局，上海市领军人才(049)，67万
13.上海市卫计委，上海市医学领军人才(90)，50万
14.市级医院新兴前沿技术联合攻关项目（SHDC12015127），《TERT启动子突变与BRAF突变共存预判甲状腺肿瘤生物行为学的临床意义》，50万
15.中央高校学科交叉类项目（1501219107），重点类项目肥胖中枢发病机制的基础和临床研究及药物筛选，80 万
16.国家基金委（国际合作与交流项目81550110260），The role of mitochondrial haplogroups in non-alcoholic fatty liver disease and type 2 diabetes.16.66万(中方申请人)
1.Wen X, You H, Wei L, Guo J, Su L, Wang L, Zhang M, Sun H, Chen H, Bu L, Qu S. Correlation Between Impaired Sensitivity to Thyroid Hormones and Serum Uric Acid in Female Patients With Obesity and After Laparoscopic Sleeve Gastrectomy. Endocr Pract. 2024 May;30(5):417-423. doi: 10.1016/j.eprac.2024.03.003. Epub 2024 Mar 11. PMID: 38479647.
2.You H, Wen X, Wang X, Zhu C, Chen H, Bu L, Zhang J, Qu S. Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting ubiquitylation and degradation of FABP1. Free Radic Biol Med. 2023 Oct;207:260-271. doi: 10.1016/j.freeradbiomed.2023.07.026. Epub 2023 Jul 25. PMID: 37499886.
3.Jayachandran M, Fei Z, Qu S. Genetic advancements in obesity management and CRISPR-Cas9-based gene editing system. Mol Cell Biochem. 2023 Mar;478(3):491-501. doi: 10.1007/s11010-022-04518-w. Epub 2022 Jul 31. PMID: 35909208.
4.You H, Wen X, Wang X, Zhu C, Zhang M, Bu L, Chen H, Sheng C, Qu S. The relationship between serum superoxide dismutase and thyroid function in obese patients after Laparoscopic sleeve gastrectomy. Free Radic Res. 2023 May-Jun;57(6-12):395-403. doi: 10.1080/10715762.2023.2265054. Epub 2023 Dec 26. PMID: 37814989.
5.Jayachandran M, Qu S. Non-alcoholic fatty liver disease and gut microbial dysbiosis- underlying mechanisms and gut microbiota mediated treatment strategies. Rev Endocr Metab Disord. 2023 Dec;24(6):1189-1204. doi: 10.1007/s11154-023-09843-z. Epub 2023 Oct 16. PMID: 37840104.
6.Yin J, Yang S, Zha X, Miao Z, Sheng C, Yang P, Wang X, Qu S. The Association of Serum Irisin with Impaired Glucose Before and After Laparoscopic Sleeve Gastrectomy in Obesity. Obes Surg. 2023 Mar;33(3):780-788. doi: 10.1007/s11695-022-06426-w. Epub 2023 Jan 19. PMID: 36656451.
7.Jayachandran M, Fei Z, Qu S. Genetic advancements in obesity management and CRISPR-Cas9-based gene editing system. Mol Cell Biochem. 2023 Mar;478(3):491-501. doi: 10.1007/s11010-022-04518-w. Epub 2022 Jul 31. PMID: 35909208.
8.Yin J, Du L, Sheng C, You H, Wang X, Qu S. Vitamin C status and its change in relation to glucose-lipid metabolism in overweight and obesity patients following laparoscopic sleeve gastrectomy. Eur J Clin Nutr. 2022 Apr 14. doi: 10.1038/s41430-022-01134-1. Epub ahead of print. PMID: 35422089
9.Yang L, Fye MA, Yang B, Tang Z, Zhang Y, Haigh S, Covington BA, Bracey K, Taraska JW, Kaverina I, Qu S, Chen W. Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion. Mol Metab. 2022 Sep;63:101541. doi: 10.1016/j.molmet.2022.101541. Epub 2022 Jul 11. PMID: 35835371; PMCID: PMC9304790.
10.Liu Y, Sheng C, Feng W, Sun F, Zhang J, Chen Y, Su L, Liu J, Du L, Jia X, You H, Huang X, Wu S, Lin Z, Qu S. A multi-center study on glucometabolic response to bariatric surgery for different subtypes of obesity. Front Endocrinol (Lausanne). 2022 Nov 3;13:989202. doi: 10.3389/fendo.2022.989202. PMID: 36407309; PMCID: PMC9669340.
11.Dilimulati D, Du L, Huang X, Jayachandran M, Cai M, Zhang Y, Zhou D, Zhu J, Su L, Zhang M, Qu S. Serum Fibrinogen-Like Protein 1 Levels in Obese Patients Before and After Laparoscopic Sleeve Gastrectomy: A Six-Month Longitudinal Study. Diabetes Metab Syndr Obes. 2022 Aug 17;15:2511-2520. doi: 10.2147/DMSO.S374011. PMID: 35999870; PMCID: PMC9393035.
12.You H, Ma H, Wang X, Wen X, Zhu C, Mao W, Bu L, Zhang M, Yin J, Du L, Cheng X, Chen H, Zhang J, Qu S. Association between liver-type fatty acid binding protein and hyperuricemia before and after laparoscopic sleeve gastrectomy. Front Endocrinol (Lausanne).
2022 Oct 6;13:993137. doi: 10.3389/fendo.2022.993137. PMID: 36277716; PMCID: PMC9582255.
13.Wang X, Zhao B, Sun H, You H, Qu S. Effects of sitagliptin on intrahepatic lipid content in patients with non-alcoholic fatty liver disease. Front Endocrinol (Lausanne). 2022 Aug 22;13:866189. doi: 10.3389/fendo.2022.866189. PMID: 36072931; PMCID: PMC9441565.
14.Zhu C, Ma H, Huang D, Li G, Gao J, Cai M, You H, Bu L, Qu S. J-Shaped Relationship Between Serum Prolactin and Metabolic-Associated Fatty Liver Disease in Female Patients With Type 2 Diabetes. Front Endocrinol (Lausanne). 2022 Feb 11;13:815995. doi: 10.3389/fendo.2022.815995. PMID: 35222274; PMCID: PMC8875202.
15.Ma B, Chen Y, Sheng C, Yang P, Wang X*, Qu S*. Correction to: Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus. Eur J Clin Nutr. 2022 May 12. doi: 10.1038/s41430-022-01156-9. Epub ahead of print. Erratum for: Eur J Clin Nutr. 2021 Nov;75(11):1645-1653. PMID: 35551256
16.Chen J, Lei S, Huang Y, Zha X, Gu L, Zhou D, Li J, Liu F, Li N, Du L, Huang X, Lin Z, Bu L*, Qu S*. The relationship between Lipocalin-2 level and hepatic steatosis in obese patients with NAFLD after bariatric surgery. Lipids Health Dis. 2022 Jan 16;21(1):10. doi: 10.1186/s12944-022-01622-0. PMID: 35034646; PMCID: PMC8761269
17.Cai M, Shao X, Xing F, Zhang Y, Gao X, Zeng Q, Dilimulati D, Qu S*, Zhang M. Efficacy of canagliflozin versus metformin in women with polycystic ovary syndrome: A randomized, open-label, noninferiority trial. Diabetes Obes Metab. 2022 Feb;24(2):312-320. doi: 10.1111/dom.14583. Epub 2021 Nov 25. PMID: 34726324.
18.Ma B, Li Y, Wang X, Du L, Wang S, Ma H, Zhou D, Usman T, Lu L, Qu S*. Association Between Abdominal Adipose Tissue Distribution and Obstructive Sleep Apnea in Chinese Obese Patients. Front Endocrinol (Lausanne). 2022 Mar 24;13:847324. doi: 10.3389/fendo.2022.847324. PMID: 35399929; PMCID: PMC8988152.
19.Ma B, Yang P, Gao J, Du L, Sheng C, Usman T, Wang X*, Qu S*. Relationship of Vitamin A and Thyroid Function in Individuals With Obesity and After Laparoscopic Sleeve Gastrectomy. Front Nutr. 2022 Mar 15;9:824193. doi: 10.3389/fnut.2022.824193. PMID: 35399676; PMCID: PMC8990331.
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同济大学