刘占举教授带领的团队主要聚焦在炎症性肠病（inflammatory bowel diseases, IBD）的临床诊治和基础转化研究，目前团队拥有医师15人、2名博士后、12名博士/硕士研究生。近年来，围绕着IBD的临床诊疗和基础研究做出了突出贡献，对IBD患者开展了易感基因和血清标志物早期诊断研究，科学地开展了对疾病分型和分层管理，实施了肠内外营养和生物免疫靶向治疗等，取得了很好的临床疗效，使患者得到康复。围绕着易感基因、肠黏膜组织内各种免疫细胞的异常免疫应答在IBD发病过程中的病理生理机制开展了深入研究，发表了一系列高水平学术论文，在国内外同行领域有很高的学术影响。

近年来，先后主持承担了多项国家自然科学基金重点项目、重大研究计划和面上项目，主要研究IBD免疫病理学发病机制。

1. 2023年国家自然科学基金面上项目（82370532）。PLXNB1调控肠黏膜Th1/Th17细胞分化在炎症性肠病发病中的机制研究。主持人，2024/1-2027/12，在研

2. 2022年上海市卫健委-中医药管理局“综合医院中医系协同引导项目”，中西医结合综合治疗炎症性肠病。主持人，2024/1-2024/11，在研

3. 2022年上海申康医院发展中心-市级医院诊疗技术推广及优化管理项目（SHDC12022118）。血清新型标志物对克罗恩病诊断效能及临床应用评估的体系建立。主持人，2022/8-2025/7，在研

1. Li G, Lin J,Gao X, Su H, Lin R, Gao H, Feng Z, Wu H, Feng B, Zuo K, Li Y, Wu W*, Fang L*, LiuZ*. Intestinal epithelial pH-sensing receptor GPR65 maintains mucosalhomeostasis via regulating antimicrobial defense and restrains gut inflammationin inflammatory bowel disease. Gut Microbes, 2023;15(2):2257269.

2. Gao H, Liu R, Huang H, LiuZ*. Susceptibility gene profiling elucidates thepathogenesis of inflammatory bowel disease and provides precision medicine. Clin Transl Med, 2023;13(9):e1404.

3. WuW, Gao X, Liu Z*. Psychological stress as a detrimental factor incolitis. Med, 2023;4(7):401-3.

4. Gao X, SunR, Jiao N, Liang X, Li G, Gao H, Wu X, Yang M, Chen C, Chen L, Wu W, Zhu R*, GuoT*, Liu Z*. Integrative multi-omics deciphers the spatial landscape of host-gutmicrobiota interactions in Crohn’s disease. Cell Rep Med, 2023;4:101050

5. ZhanjuLiu#*, Liu RZ#, Gao H#, Jung S, Gao X, Sun R, Liu X, Kim Y, Lee HS, Kawai Y, Nagasaki M, Umeno J, TokunagaK, Kinouchi Y, Masamune A, Shi W, Shen C, Guo Z, Yuan K, FinnGen, InternationalInflammatory Bowel Disease Genetics Consortium, Chinese Inflammatory BowelDisease Genetics Consortium, Zhu S, Li D, Liu J, Ge T, Cho J, Daly MJ, McGovernDPB, Ye BD, Kyuyoung Song*, Yoichi Kakuta*, Mingsong Li*, Hailiang Huang. Genetic architecture of the inflammatory bowel diseasesacross East Asia and European ancestries. Nature Genetics, 2023;55(5):796-806.

6. LuH, Zhang C, Wu W, Chen H, Lin R, Sun R, Gao X, Li G, He Q, Gao H, Wu X, Lin J, ZhuR, Niu J, Kolattukudy PE, Liu Z*. MCPIP1 restrains mucosal inflammation byorchestrating the intestinal monocyte to macrophage maturation via an ATF3-AP1S2axis. Gut, 2023;72(5):882-895.

7. Chen H, Wu X, Sun R, Lu H, Lin R, Gao X, Li G, FengZ, Zhu R, Yao Y, Feng B, Liu Z*. Dysregulationof CD177+ neutrophils on intraepithelial lymphocytes exacerbates gutinflammation via decreasing microbiota-derived MDF. Gut Microbes, 2023;15(1):2172668.

8. Feng Z, Sun R, Cong Y, Liu Z*. Critical roles of G protein-coupled receptors inregulating intestinal homeostasis and inflammatory bowel disease. MucosalImmunol, 2022;15(5):819-28.

9. He Q, Gao H, Chang YL, Wu X, Lin R, Li G, Lin J, Lu H, Chen H, LiZ, Cong Y, Yao J*, LiuZ*. ETS-1 facilitates Th1 cell-mediated mucosal inflammationin inflammatory bowel disease through upregulating CIRBP. J Autoimmun, 2022;132:102872.

10. GaoH, He Q，Xu C, Pang Z, Feng B, ChenT, Yang W, Zhou G, Wang Y, Li J, Su J, Miao Y, Zhao Y, Liao, Xu C, Liu Z*.The development and validation of anti-paratuberculosis-nocardia polypeptide antibody(anti-pTNP) for the diagnosis of Crohn's disease. J Crohns Colitis, 2022;16(7):1110-23.

11. LinR, Wu W, Chen H, Gao H, Wu X, Li G, He Q, Lu H, Sun M, Liu Z*.GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammationthrough downregulating NUAK2. Clin Transl Med, 2022;12:e771

12. Li G, Lin J,Zhang C, Gao H, Lu H, Gao X, Zhu R, Li Z, Li M*, LiuZ*. Butyrate constrains neutrophil functions and amelioratesmucosal inflammation in inflammatory bowel disease. Gut Microbes, 2021;13(1):1968257.

13. Lu H, Lin J, Xu C, Sun M,Zuo K, Zhang X, Li M, Huang H, Li Z, Wu W*, Feng B*, Liu Z*. Cyclosporine modulates neutrophilfunctions via the SIRT6-HIF-1a-glycolysis axis to alleviate severe ulcerative colitis.Clin Transl Med, 2021;11(2):e334.

14. Yang W, Yu T, Huang X, Bilotta AJ, Xu L, Lu Y, Sun J, Pan F, Zhou J,Zhang W, Yao S, Maynard CL, Singh N, Dann SM, Liu Z, Cong Y*. Intestinal microbiota-derived short-chainfatty acids regulation of immune cell IL-22 production and gut immunity. Nat Commun. 2020;11(1):4457.

15. GeY, Sun M, Wu W, Ma C, Zhang C, He C, Li J, Cong Y, Zhang D*, Liu Z*. MicroRNA-125a suppressesintestinal mucosal inflammation through targeting ETS-1 in patients with inflammatorybowel diseases. J Autoimmun 2019;101:109-120.

16. TianY, Xu J, Li Y, Zhao R, Du S, Lv C, Wu W, Liu R, Sheng X, Song Y, Bi X, Li G, LiM, Wu X, Lou P, You H, Cui W, Sun J, Shuai J, Ren F, Zhang B, Guo M, Hou X, WuK, Xue L, Zhang H, Plikus MV, Cong Y, Lengner CJ, Liu Z*, Yu Z*. MicroRNA-31 reduces inflammatorysignaling and promotes regeneration in colon epithelium, and delivery of mimicsin microsperes reduces colitis in mice. Gastroenterology, 2019;156(8):2281-96.

17. MaC, Wu W, Lin R, Ge Y, Zhang C, Sun S,Cong Y,Li X, LiuZ*. Critical role of CD6highCD4+T cells in driving Th1/Th17 cell immune responses and mucosal inflammation inIBD. J Crohn Colitis, 2019;13(4):510-524.

18. HuX, Deng J, Yu T, Chen S, Ge Y, Zhou Z, Guo Y, Ying H, Zhai Q, Chen Y, Yuan F,Niu Y, Shu W, Chen H, Ma C, Liu Z*,Guo F*. ATF4 deficiencypromotes intestinal inflammation in mice by reducing uptake of glutamineand expression of antimicrobial peptides.Gastroenterology, 2019;156(4):1098-1111.

19. SunM, Wu W, Chen L, Yang W, Huang X, Ma C, Chen F, Xiao Y, Zhao Y, Ma C, Yao S,Carpio VH, Dann SM, Zhao Q, Liu Z*,Cong Y*. Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 productionto maintain intestinal homeostasis. Nat Commun, 2018;9(1):3555.

20. Shi Y#, He C#, Ma C, Yu T, Cong Y, Cai W*, Liu Z*. Smadnuclear interacting protein 1 (SNIP1) inhibits intestinal inflammation throughregulation of epithelial barrier function. Mucosal Immunol, 2018;11(3):835-845.

21. Zhou G, Wu W, Yu L, Yu T, YangW, Wang P, ZhangX*, Cong Y*, Liu Z*. Tripartitemotif-containing (TRIM)21 negatively regulates intestinal mucosal inflammation through inhibiting Th1/Th17cell differentiation in patients with inflammatory bowel disease. J AllergyClin Immunol, 2018;142(4):1218-28.

22. Zhou G, Yu L, Fang L, Song Y, Yang W, YuT, Miao Y, Chen M, Wu K, Chen F, Cong Y*, LiuZ*. CD177+neutrophils as functionally activated neutrophils negatively regulateinflammatory bowel disease. Gut, 2018;67(6):1052-63.

23.  YangW, Zhou G, Yu T, Chen L, Yu L, Guo Y, Cong Y, Liu Z*. Critical role of ROCK2 activityin facilitating mucosal CD4+ T cell activation in inflammatory boweldisease. J Autoimmun 2018;89:125-138.