1         项目来源：国家重点研发计划；课题骨干；项目名称：心肌组织再生修复的微环境调控与功能整合；项目编号：2022YFA1104503；项目经费：214万元；起止年月：2022/12-2027/11。

2        项目来源：国家自然科学基金委员会（重点项目）；课题负责人；项目名称：Foxp1在动脉粥样硬化病程中调控巨噬细胞异质性的分子机制研究；项目编号：82130016；项目经费：290万元；起止年月：2022/01-2026/12。

3        项目来源：国家自然科学基金委员会（面上项目）；课题负责人；项目名称：WISP2调节血管平滑肌细胞增殖迁移控制内膜增生作用和机制研究；项目编号：81970233；项目经费：55 万元；起止年月：2020/01-2023/12。

4        项目来源：上海市科学技术委员会基础研究领域项目；课题负责人；项目名称：通过谱系示踪技术研究转录因子Foxp1对心脏纤维化过程中肌成纤维细胞的来源、命运和转归的影响；项目编号：19JC1414500；项目经费：36万元；起止年月：2019/11-202/10。

5        项目来源：国家自然科学基金委员会（面上项目）；课题负责人；项目名称：转录因子Foxp1在压力超负荷致心室重构中的作用和机制研究；项目编号：81770259；项目经费：55万元；起止年月：2018/01-2021/12。

6        项目来源：国家自然科学基金委员会（重大研究计划培育项目）；课题负责人；项目名称：Foxp1介导IL-1b/Lox-1调节内皮细胞/单核巨噬细胞交互作用在动脉粥样硬化发生发展中的作用；项目编号：91639112；项目经费：65 万元；起止年月：2017/01-2019/12。

7        项目来源：国家自然科学基金委员会（面上项目）；课题负责人；项目名称：Gata6对血管损伤修复和动脉粥样硬化形成的作用及其机制；项目编号：81170116；项目经费：52万元；起止年月：2012/01-2015/12。

8        项目来源：国家重点基础研究计划；子课题负责人；项目名称：干细胞分裂模式和干细胞干性维持的机制研究-miRNA和蛋白质修饰在干细胞对称/不对称分裂过程中的作用及机理；项目编号：2012CB966800；项目经费：600万元；起止年月：2012/01-2016/08。

9        项目来源：上海市科委（上海市浦江人才计划）；课题负责人；项目名称：Foxp1调控巨噬细胞极性/可塑性与动脉粥样硬化的形成发展； 项目编号： 13PJ1407000；项目经费：20万元；起止年月：2013/11-2015/11。

1.       LiuC, Liu L, Wang Y, Chen X, Liu J, Peng S, Pi J, Zhang Q, Tomlinson B, Chan P,Zhang L, Fan H, Zheng L, Liu Z, Zhang Y. Hyperhomocysteinemia IncreasesRisk of Metabolic Syndrome and Cardiovascular Death in an Elderly ChineseCommunity Population of a 7-Year Follow-Up Study. Front Cardiovasc Med. 2022Feb 10; 8: 811670.

2.       WangY, Liu C, Liu L, Chen X , Wei L , Liu J, Peng S , Pi J ,Zhang Q , Tomlinson B.Chan P , Zhang L , Fan H, Zheng L , Liu Z ,Zhang Y. Association ofElevated Thyroid Stimulating Hormone with Atherosclerotic Cardiovascular Diseaseand Its Mortality in Elderly Community-Dwelling Chinese. Clinical Interventionsin Aging. 2022:17 1139–1150

3.       Wu W, BaoW, Chen X, Lu Y, Fang J, Liu J, Peng S, Pi J, Tomlinson B, Chan P, Zhang Q, ZhangL,

Liu Z, Liu J, Zhang Y, Zhuang T. EndothelialGata6 deletion reduces monocyte recruitment and

proinflammatorymacrophage formation and attenuates atherosclerosis through Cmpk2-Nlrp3pathways. Redox Biology.2022

4.       KuangY, Li X, Liu X, Wei L, Chen X, Liu J, Zhuang T, Pi J, Wang Y, Zhu C,Gong X, Hu H, Yu Z, Li J, Yu P, Fan H, Zhang Y, Liu Z,Zhang L. Vascularendothelial S1pr1 ameliorates adverse cardiac remodelling via stimulatingreparative macrophage proliferation after myocardial infarction. CardiovascRes. 2021

5.       YuH, Zhang F, Yan P, Zhang S, Lou Y, Geng Z, Li Z, Zhang Y, Xu Y, Lu Y, ChenC, Wang D, Zhu W, Hu X, Wang J, Zhuang T, Zhang Y, Wu G, Liu J, Zeng C, Pu WT, Sun K, Zhang B.  LARP7 Protects Against Heart Failure byEnhancing Mitochondrial Biogenesis. Circulation. 2021

6.       YanP, Li Z, Xiong J, Geng Z, Wei W, Zhang Y, Wu G, Zhuang T, Tian X, Liu Z,Liu J, Sun K, Chen F, Zhang Y,Zeng C, Huang Y, Zhang B. LARP7 ameliorates cellular senescence and aging byallosterically enhancing SIRT1 deacetylase activity. Cell Rep. 2021

7.       WangR, Wu ST, Yang X, Qian Y, Choi JP, Gao R, Song S, Wang Y, Zhuang T, WongJJ, Zhang Y, Han Z, Lu HA, AlexanderSI, Liu R, Xia Y, Zheng X. Pdcd10-Stk24/25complex controls kidney water reabsorption by regulating Aqp2 membranetargeting. JCI Insight. 2021

8.       ZhuJ, Yang Z, Li X, Chen X, Pi J, Zhuang T, Liu J, Li G, Peng S, Zhang L, Zhang Q,Chan P, Tomlinson B, Fan H, Zheng L, Liu Z, Zhang Y. Associationof Periaortic Fat and Abdominal Visceral Fat with Coronary ArteryAtherosclerosis in Chinese Middle Aged and Elderly Patients Undergoing ComputedTomography Coronary Angiography. Glob Heart. 2021

9.       ZhuJ, Yang Z, Chen X, Liu J, Zheng L, Zhang L, Pi J, Li G, Zhuang T, Liu C,Wang Y, Liu L, Fan L, Chan P, Tomlinson B, Li Y, Liu Z, Zhang Y. A Stronger Association of EpicardialFat Volume with Non-Valvular Atrial Fibrillation Than Measures of GeneralObesity in Chinese Patients Undergoing Computed Tomography CoronaryAngiography. Diabetes Metab Syndr Obes. 2021

10.   LiH, Wang Y, Liu J, Chen X, Duan Y, Wang X, Shen Y, Kuang Y, Zhuang T, TomlinsonB, Chan P, Yu Z, Cheng Y, Zhang L, Liu Z, Zhang Y, Zhao Z, Zhang Q, Liu J. Endothelial Klf2-Foxp1-TGFβ signalmediates the inhibitory effects of simvastatin on maladaptive cardiacremodeling. Theranostics. 2021 

11.   Zhen L, Zhao Q, Lü J, Deng S, Xu Z, ZhangL, Zhang Y, Fan H, Chen X, LiuZ, Gu Y, Yu Z. miR-301a-PTEN-AKT Signaling Induces Cardiomyocyte Proliferation andPromotes Cardiac Repair Post-MI. Mol Ther Nucleic Acids. 2020

12.   Tomlinson B, Chan P, Zhang Y, Lam CWK. Efficacy andsafety of add on therapies in patients with hypercholesterolemia undergoingstatin therapy. Expert Opin Pharmacother. 2020 

13.   Tomlinson B, Chan P, Zhang Y, Liu Z,Lam CWK. Pharmacokinetics of current and emerging treatments for hypercholesterolemia.ExpertOpin Drug Metab Toxicol. 2020

14.   Lin CH, Shao L, Zhang YM, TuYJ, Zhang Y, Tomlinson B, ChanP, Liu Z. An evaluation of liraglutide including its efficacy and safety for thetreatment of obesity. Expert Opin Pharmacother. 2020 

15.   Liu X, Wu J, Zhu C, Liu J, Chen X, ZhuangT, Kuang Y, Wang Y, Hu H, Yu P, Fan H, Zhang Y#, Liu Z,Zhang L. Endothelial S1pr1 regulates pressure overload-induced cardiac remodellingthrough AKT-eNOS pathway. J Cell Mol Med. 2020  

16.   LiuJ, Zhuang T, Pi J, Chen X, Zhang Q, Li Y, Wang H, ShenY, Tomlinson B, Chan P, Yu Z, Cheng Y, Zheng X, Reilly M,Morrisey E, Zhang L, Liu Z, Zhang Y. Endothelial Foxp1 RegulatesPathological Cardiac Remodeling Through TGF-β1-Endothelin-1 Signal Pathway.Circulation. 2019

17.  Zhuang T, Liu J, Chen X,Zhang L, Pi J, Sun H, Li L, Bauer RC, Wang H, Yu Z, Zhang Q, Tomlinson B, ChanP, Zheng X, Morrisey E, Liu Z, Reilly M, ZhangY. EndothelialFoxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 InflammasomeActivation. Circ Res 2019.

18.   ZhuangT, Liu J, Chen X, Pi J, Kuang Y, Wang Y, Tomlinson B, Chan P, Zhang Q,Li Y, Yu Z, Zheng X, Reilly M, Morrisey E, Zhang L, Liu Z, Zhang Y. Cell-SpecificEffects of GATA (GATA Zinc Finger Transcription Factor Family)-6 in VascularSmooth Muscle and Endothelial Cells on Vascular Injury Neointimal Formation.Arterioscler Thromb Vasc Biol. 2019

19.  Wang Y, Liu J, Chen X,Sun H, Peng S, Kuang Y, Pi J, Zhuang T, Zhang L, Yu Z, Tomlinson B, Chan P,Chen Y, Zhang Y, Li Y. Dysfunctional endothelial-derived microparticlespromote inflammatory macrophage formation via NF-кB and IL-1β signal pathways.J Cell Mol Med. 2019.

20.     ChanP, Shao L, Tomlinson B, Zhang Y, Liu ZM. An evaluation of pitavastatin for thetreatment of hypercholesterolemia. Expert Opin Pharmacother. 2019; 20(1):103-113.

21.     Zhuang R, Ge X, Han L, Yu P, Gong X, Meng Q, Zhang Y, Fan H, Zheng L, Liu Z, Zhou X.Gut microbe-generated metabolite trimethylamine N-oxide and the risk ofdiabetes: A systematic review and dose-response meta-analysis. ObesRev. 2019.

22.     MaYB, Chan P, Zhang Y, TomlinsonB, Liu Z. Evaluating the efficacy and safety of atorvastatin +ezetimibe in afixed-dose combination for the treatment of hypercholesterolemia. Expert OpinPharmacother. 2019 

23.     TaoM, Pi X, Ma X, Shi Y, Zhang Y, Gu H, Chi Y, Zhuang S, Liu N. Relationship between serum uric acidand clustering of cardiovascular disease risk factors and renal disordersamong Shanghai population: a multicentre and cross-sectional study.BMJ Open. 2019

24.     PiJ, Liu J, Zhuang T, Zhang L, Sun H, Chen X, Zhao Q, Kuang Y, Peng S, Zhou X, YuZ, Tao T, Tomlinson B, Chan P, Tian Y, Fan H, Liu Z1, Zheng X, Morrisey E, ZhangY. Elevated Expression of miR302-367 in Endothelial Cells InhibitsDevelopmental Angiogenesis via CDC42/CCND1 Mediated Signaling Pathways.Theranostics 2018.

25.     YuanJ, Hu Z, Mahal BA, Zhao SD, Kensler KH, Pi J, Hu X, Zhang Y, Wang Y,Jiang J, Li C, Zhong X, Montone KT, Guan G, Tanyi JL, Fan Y, Xu X, Morgan MA,Long M, Zhang Y, Zhang R, Sood AK, Rebbeck TR, Dang CV, Zhang L. Integrated Analysis of GeneticAncestry and Genomic Alterations across Cancers. Cancer Cell. 2018

26.     ChanP, Shao L, Tomlinson B, Zhang Y, Liu ZM. Metformin transporterpharmacogenomics: insights into drug disposition-where are we now?Expert Opin Drug Metab Toxicol. 2018

27.     Pi J, Tao T, Zhuang T, Sun H, Chen X, Liu J, Cheng Y, Yu Z, Zhu HH, Gao WQ, Suo Y, Wei X, Chan P, Zheng X,TianY, Morrisey E, Zhang L, Zhang Y. A MicroRNA- 302-367-Erk1/2- Klf2-S1pr1 PathwayPrevents Tumor Growth via Restricting Angiogenesis and Improving VascularStability. Circulation Research. 2017; 120(1):85-98.

28.    Peng S, Shen T, Liu J,Tomlinson B, Sun H, Chen X, Paul Chan, Kuang Y, Zheng L, Wu H, Ding X, Qian D,Shen Y, Gao P, Fan H, Liu Z, Zhang Y.Uncontrolled Hypertension Increases with Age in an Older Community-DwellingChinese Population in Shanghai. Aging Dis. 2017

29.     Shao X, Ding Z, Zhao M, Liu K, Sun H,Chen J, Liu X, Zhang Y, Hong Y, Li H, Li H. MammalianNumb protein antagonizes Notch by controlling postendocytic trafficking of theNotch ligand Delta-like 4. J Biol Chem. 2017

30.     Tomlinson B, Hu M, Zhang Y, Chan P, Liu ZM. Liraglutide for weightmanagement: benefits and risks. Curr Med ResOpin. 2017.

31.     Kuang Y, Li X, Chen X, Sun H, Tomlinson B, Chan P, Zheng L, Pi J, Peng S, Wu H, Ding X, Qian D, Shen Y, Yu Z, Fan L,Chen M, Fan H, Liu Z, ZhangY. Higher prevalence of elevated LDL-C than non-HDL-C and low statintreatment rate in elderly community-dwelling Chinese with high cardiovascularrisk. Sci Rep. 2016

32.     FanH, Li X, Zheng L, Chen X, Lan Q, Wu H, Ding X, Qian D, Shen Y, Yu Z, Fan L,Chen M, Tomlinson B, Chan P, Zhang Y, Liu Z.Abdominal obesity is stronglyassociated with Cardiovascular Disease and its Risk Factors in Elderly and veryElderly Community-dwelling Chinese. Sci Rep. 2016 

33.     TomlinsonB, Hu M, Zhang Y, Chan P, Liu ZM. Effects of glucose-lowering drugs oncardiovascular outcomes in patients with type 2 diabetes. ExpertOpin Drug Metab Toxicol. 2016

34.     TomlinsonB, Hu M, Zhang Y, Chan P, Liu ZM. An overview of new GLP-1receptor agonists for type 2 diabetes. Expert Opin Investig Drugs.2016

35.     LiangD, Li J, Wu Yahan, Zhen LX, Li CM, Qi M, Wang LJ, Deng F, Huang J, Lv F, Liu Y,Ma XE, Yu ZR, Zhang Y, Chen YH.miRNA-204 drives cardiomyocyte Proliferation via targeting Jarid2. Int JCardiol. 2015.

36.     Zheng L,Lan Q, Zhang Y, Feng J, Wang G, Li X, Kang S,Li J, Fan H, Liu Z. The screening value of baPWV andhs-crp to ASCVD in middle and elderly community population in Shanghai. Int JCardiol. 2015

37.     LiangD, Xu X, Deng F, Feng J, Zhang H, Liu Y, Zhang Y, Pan L, Liu Y, Zhang D,Li J, Liang X, Sun Y, Xiao J, Chen YH. miRNA-940 reduction contributes to humanTetralogy of Fallot development. J Cell Mol Med. 2014

38.     ShiD, Xie D, Zhang H, Zhao H, Huang J, Li C, Liu Y, Lv F, The E, Liu Y, Yuan T,Wang S, Chen J, Pan L, Yu Z, Liang D, Zhu W, Zhang Y, Li L, Peng L, LiJ, Chen YH. Reduction in dynamin-2 is implicated in ischaemic cardiacarrhythmias. J Cell Mol Med. 2014

39.     Yu Z,Wang L, Wang C, Ju X, Wang M, Chen K, Loro E, Li Z, Zhang Y, Wu K,Casimiro MC, Gormley M, Ertel A, Fortina P, Chen Y, Tozeren A, Liu Z, Pestell RG.Cyclin D1 induction of Dicer governsmicroRNA processing and expression in breast cancer. Nat Commun.2013

40.     LiJ, Xu L, Ye J, Li X, Zhang D, Liang D, Xu X, Qi M, Li C, Zhang H, Wang J, Liu Y,Zhang Y, Zhou Z, Liang X, Li J, Peng L, Zhu W, Chen YH. Aberrant dynamin2-dependent Na(+) /H(+) exchanger-1 trafficking contributes to cardiomyocyteapoptosis. J Cell Mol Med. 2013

41.     LiS, Wang Y, Zhang Y, Lu MM, DeMayo FJ, Dekker JD, Tucker PW, Morrisey EE.Foxp1/4 control epithelial cell fateduring lung development and regeneration through regulation of anteriorgradient 2. Development. 2012

42.     TianY, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu MM, Morrisey EE.Regulation of lung endoderm progenitor cell behavior by miR302/367. Development. 2011. 

43.     Anokye-­DansoF, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, GruberPJ, Epstein JA, and Morrisey EE.  Highlyefficient miRNA mediated reprogramming of somatic cells to induced pluripotentstem cells. Cell Stem Cell 2011.

44.     ZhangY, McGillicuddy FC, Hinkle CC, O'Neill S,Glick JM, Rothblat GH, Reilly MP. Adipocyte modulation of high-density lipoprotein cholesterol.Circulation 2010.

45.     ZhangY, Li S, Yuan A, Tian Y, Yang J, Liu F,Chokas A, Morrisey. Foxp1 coordinates cardiomyocyte proliferation through bothcell autonomous and non-autonomous mechanisms. Genes & Dev 2010.

46.     ZhangY, Goss AM, Cohen ED, Kadzik R, Lepore JJ,Muthukumaraswamy K, Yang J, DeMayo FJ, Whitsett JA, Parmacek MS, Morrisey EE. A Gata6-Wntpathway required for epithelial stem cell development and airway regeneration.Nat Genet 2008.

47.     ZhangY, Rath N, Hannenhalli S, Wang Z, CappolaT, Kimura S, Atochina-Vasserman E, Lu MM, Beers MF, Morrisey EE. GATA and Nkxfactors synergistically regulate tissue-specific gene expression anddevelopment in vivo. Development 2007.

48.     ShuW, Lu MM, Zhang Y, Tucker PW, Zou D, Morrisey EE. Foxp2 and Foxp1cooperatively regulate lung and esophagus development.  Development 2007.

49.     TanigawaH, Billheimer JT, Tohyama J, Zhang Y, Rothblat G, Rader DJ. Expressionof cholesteryl ester transfer protein in mice promotes macrophage reversecholesterol transport. Circulation 2007.

50.     ZhangY, Da Silva JR, Reilly M, Billheimer JT,Rothblat GH, Rader DJ. Hepatic expression of scavenger receptor class B type I(SR-BI) is a positive regulator of macrophage reverse cholesterol transport invivo. J Clin Invest. 2005

51. Zhang YZ,Zanotti I, Reilly M; Glick J M, Rothblat G H, and Rader D J. Overexpression ofapoA-I promotes reverse transport of cholesterol from macrophages to feces invivo. Circulation 2003

52.     KawashiriM, Zhang YZ, Pure E, Rader DJ: Combined effects of cholesterol reductionand apolipoprotein A-I expression on atherosclerosis in LDL receptor deficientmice. Atherosclerosis.

53.     StepienO, Zhang YZ, Zhu D, Marche P: Dual mechanism of action of amlodipine inhuman vascular smooth muscle cells. J Hypertens 2002.

54.     KawashiriM, Zhang YZ, Usher D, Reilly M, Pure E, Rader DJ: Effects ofcoexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosisin LDL receptor-deficient mice. J Lipid Res 2001