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一直从事肿瘤基因组进化与神经系统肿瘤耐药、治疗及机制研究，原创性地提出并阐明DNA损伤下复制体动态异构模型，开展以胶质瘤为主的神经系统恶性肿瘤治疗新策略、药物研发，及脑损伤后神经功能调控与修复工作，致力于以临床需求为目标的科研和医学转化研究。近期相关工作发表在国际著名期刊Nature Communications, Cell Reports，Journal of Experimental & Clinical Cancer Research，Cell Death & Disease，CNS Neuroscience & Therapeutics等杂志，获得美国国立卫生研究院（NIH）研究卓越贡献奖，上海市医学科技三等奖。主持国家自然科学基金、上海市自然科学基金等，并作为项目骨干获得上海市浦东新区临床高原学科、急危重症重点学科群临床科研项目等资助。
1.上海市海外高层次人才引进计划
2.同济大学青年百人计划
3.国家自然科学基金面上项目
4.上海市自然科学基金面上项目
5.上海市卫健委卫生行业临床专项
1. Jing Zhang, Marina A. Bellani, Ryan C. James, Durga Pokharel, Yongqing Zhang, John J. Reynolds, Gavin S. McNee, Andrew P. Jackson, Grant S. Stewart, Michael M. Seidman. DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain, Nature Communications, 2020, 11(1): 3951
2. Jing Zhang, Mu Chen, Ying Pang, Meng Cheng, Bingsong Huang, Siyi Xu, Min Liu, Hao Lian, Chunlong Zhong. Flap endonuclease 1 and DNA-PKcs Synergistically Participate in Stabilizing Replication Fork to Encounter Replication Stress in Glioma Cells, Journal of Experimental & Clinical Cancer Research, 2022, 41(1): 140
3. Jing Zhang, Li Jing, Subee Tan, Er-Ming Zeng, Yingbo Lin, Lingfeng He, Zhigang Hu, Jianping Liu, Zhigang Guo. Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs, Cell Death & Disease, 2020, 11(7): 602
4. Jing Huang, Jing Zhang, Marina A. Bellani, Durga Pokharel, Julia Gichimu, Ryan C. James, Himabindu Gali, Chen Ling, Zhijiang Yan, Dongyi Xu, Junjie Chen, Amom Ruhikanta Meetei, Lei Li, Weidong Wang, Michael M. Seidman. Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2, Cell Reports, 2019, 27(6): 1794-1808
5. Tongjie Ji; Ying Pang; Meng Cheng; Rui Wang; Xu Chen; Chunyu Zhang; Min Liu; Jing Zhang; Chunlong Zhong; Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long-term benefits in mice with traumatic brain injury, CNS Neuroscience & Therapeutics, 2023
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同济大学