1)   国家自然科学基金面上项目，82173786，基于活细胞特异荧光探针检测的真菌CYP51抑制剂实时原位构效关系探索及其作为抗真菌药物发现新方法研究，55 万元，2022/01-2025/12,主持

2)    国家自然科学基金重点项目，81830106，基于抗耐药真菌新先导物和新机制的药物发现研究，293 万元，2019/01-2023/12,在研，主持

3)  上海市 “科技创新行动计划”生物医药科技支撑专项项目, 21S11901300，新型高效抗隐球菌活性化合物的作用机制与结构优化研究, 30万元,2021/07/01-2024/06/30, 在研，主持

1)   国家自然科学基金面上项目，82173786，基于活细胞特异荧光探针检测的真菌CYP51抑制剂实时原位构效关系探索及其作为抗真菌药物发现新方法研究，55 万元，2022/01-2025/12,主持

2)    国家自然科学基金重点项目，81830106，基于抗耐药真菌新先导物和新机制的药物发现研究，293 万元，2019/01-2023/12,在研，主持

3)  上海市 “科技创新行动计划”生物医药科技支撑专项项目, 21S11901300，新型高效抗隐球菌活性化合物的作用机制与结构优化研究, 30万元,2021/07/01-2024/06/30, 在研，主持

1.获奖：

2020年教育部科技进步一等奖，抗真菌药物研发创新体系的建立与应用（第1完成人）

2.论文（近3年代表性论文）

1)   JunheBao, Yumeng Hao, Tingjunhong Ni, Ruina Wang, Jiacun Liu, Xiaochen Chi, TingWang, Shichong Yu, Yongsheng Jin, Lan Yan, Xiaomei Li*, Dazhi Zhang*，FeiXie*. Design, synthesis and in vitro biological studies of novel triazoles withpotent and broad-spectrum antifungal activity. Journal of Enzyme Inhibition andMedicinal Chemistry, 2023, 38(1): 2244696

2)   XiaochenChi; Fei Xie; Liping Li; Yumeng Hao; Hao Wu; Xianru Li; Guangxin Xia; Lan Yan;Dazhi Zhang*; Yuanying Jiang*; Tingjunhong Ni*. Discovery of novel triazolescontaining benzyloxy phenyl isoxazole side chain with potent and broad-spectrumantifungal activity. Bioorganic Chemistry, 2023, 137：106572

3)  FeiXie; Yumeng Hao; Liping Li; Ruina Wang; Junhe Bao; Xiaochen Chi; Brian C. Monk;Ting Wang; Shichong Yu; Yongsheng Jin; Dazhi Zhang*; Tingjunhong Ni*; Lan Yan*.Novel antifungal triazoles with alkynyl-methoxyl side chains: Design,synthesis, and biological activity evaluation. European Journal of MedicinalChemistry, 2023, 257：115506

4)  TingjunhongNi; Fei Xie; Liping Li; Yumeng Hao; Xiaochen Chi; Lan Yan; Dazhi Zhang*;Yuanying Jiang*; Quanzhen Lv*. Design, Synthesis and Structure-ActivityRelationship Studies of Nicotinamide Derivatives as Potent Antifungal Agents byDisrupting Cell Wall. Molecules, 2023, 28(3):1135

5)      TingjunhongNi, Fei Xie, Yumeng Hao, Liping Li, Shuo Zhu, Hao Wu, Xiaochen Chi, Lan Yan,Yuanying Jiang*, and Dazhi Zhang*. Discovery of Novel Orally BioavailableTriazoles with Potent and Broad-Spectrum Antifungal Activity In Vitro and InVivo. Journal of Medicinal Chemistry, 2022, 65, 24, 16665–16678

6)  HuiLu, Wanqian Li, Malcolm Whiteway, Hongkang Wang, Shuo Zhu, Zhe Ji, Yanru Feng,Lan Yan, Ting Fang, Liping Li, Tingjunhong Ni, Xiaolong Zhang, Quanzhen Lv,Zichao Ding, Lijuan Qiu, Dazhi Zhang*, Yuanying Jiang*. A Small MoleculeInhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis ofthe 14α-Methylsterols. mBio, 2022，12：e0263922 

7)  TingjunhongNi†, Xiaochen Chi†, Fei Xie†, Liping Li, HaoWu, Yumeng Hao, Xiaobo Wang*, Dazhi Zhang*, Yuanying Jiang*.Design, synthesis, and evaluation of novel tetrazoles featuring isoxazolemoiety as highly selective antifungal agents. European Journal of MedicinalChemistry, 2022，246:115007

8)  FeiXie, Yumeng Hao†, Jiacun Liu†, Junhe Bao, Tingjunhong Ni, Yu Liu, Xiaochen Chi,Ting Wang, Shichong Yu, Yongsheng Jin, Liping Li, Dazhi Zhang,* and Lan Yan*.Discovery of Novel Thiosemicarbazides Containing 1,3,5-Triazines Derivatives asPotential Synergists against Fluconazole-Resistant Candida albicans.Pharmaceutics, 2022, 14, 2334

9)  FeiXie , Yumeng Hao, Junhe Bao, Jiacun Liu, Yu Liu, Ruina Wang, Xiaochen Chi,Xiaoyun Chai, Ting Wang, Shichong Yu, Yongsheng Jin, Lan Yan*, Dazhi Zhang*,Tingjunhong Ni *. Design, synthesis, and in vitro evaluation of novelantifungal triazoles containing substituted 1,2,3-triazole-methoxyl sidechains. Bioorganic Chemistry, 2022,19, 106216

10) LipingLi#, Hao Wu#, Shuo Zhu, Zhe Ji, Xiaochen Chi, Fei Xie, Yumeng Hao, Hui Lu, FengYang, Lan Yan, Dazhi Zhang*, Yuanying Jiang*, Tingjunhong Ni*. Discovery ofNovel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamideDerivatives with Potent and Selective Antifungal Activity against CryptococcusSpecies. Journal of Medicinal Chemistry, 2022，65(16):11257-11269

11)  TingjunhongNi †, Zichao Ding †, Fei Xie †, Yumeng Hao, Junhe Bao, Jingxiang Zhang,Shichong Yu*,Yuanying Jiang*，Dazhi Zhang*. Design, Synthesis, andIn Vitro and In Vivo Antifungal Activity of Novel Triazoles Containing phenylethynylPyrazole Side Chains. Molecules. 2022; 27(11): 3370.

12)  LipingLi#, Hui Lu#, Xuan Zhang, Malcolm Whiteway, Hao Wu, Shanlun Tan, Jianye Zang, ShujuanTian, Cheng Zhen, Xianlei Meng, Wanqian Li, Dazhi Zhang*, Min Zhang*, YuanyingJiang*. Baicalein Acts against Candida albicans by Targeting Eno1 andInhibiting Glycolysis. Microbiology Spectrum. 2022，10（4）： e0208522

13)  NingWang#, Yumeng Hao#, Xiaowei Feng, Haidan Zhu, Dazhi Zhang, Ting Wang*, Xiaoyan Cui*.Silicon-substituted rhodamines for stimulated emission depletion fluorescencenanoscopy. Chinese Chemical Letters. 33 (2022) 133–140

14)  XiaofengLin#, Mengting Fan#, Ni Li, Jiaojiao Yang, Haidan Zhu, Bo Chen, Junru Zhu,Dazhi Zhang*, Ting Wang*, Xiaoyan Cui*. Phosphorus-substituted rhodamines for bioimaging of the lysosomalperoxynitrite in vivo. Dyes and Pigments 2022，201:110201

15)  MengtingFan, Haiyan An, Chuanfeng Wang, Shuhui Huo, Ting Wang*, Xiaoyan Cui*, DazhiZhang*. STED imaging the dynamic of lysosomes by dually fluorogenicSi-rhodamine. Chemistry-A European Journal, 2021,27(37): 9620-9626，

16)  Kai-XiaZhang, Xi-Jing Qian, Wei Zheng, Meng-Cheng Cai, Ying Ma, Da-Zhi Zhang,Shi-Chong Yu, Qing-Guo Meng* and Yong-Sheng Jin*.  Synthesis and In Vitro anti-HCV and AntitumorEvaluation of Schisandronic Acid Derivatives. Medicinal Chemistry, 2021;17(9):974-982.

17)  MinWen, Xijing Wang, Ting Wang, Yan Sun, Mengting Fan, Min Li, Junru Zhu, DazhiZhang, Xiaoyan Cui, Yongkui Shan.Acridinium Benzoates for RatiometricFluorescence Imaging. Chemistry-A European Journal, 2020, 26(15)：3247-3251,

18)  Huai-HuaiDong, Yuan-Hua Wang, Xue-Mi Peng, He-Yang Zhou, Fei Zhao, Yuan-Ying Jiang,Da-Zhi Zhang*, Yong-Sheng Jin*. Synergistic antifungal effects of curcuminderivatives as fungal biofilm inhibitors with fluconazole. Chem Biol Drug Des.2021,97(5): 1079-1088,

19)  ZichaoDing#; Chuanfeng Wang#; Mengting Fan; Mengyuan Zhang; Yao Zhou; Xiaoyan Cui*; DazhiZhang*, Ting Wang*. Far-redimaging of b-galactosidase through a phospha-fluorescein. Chem. Commun.;2020,56, 13579, IF: 6.039

20)  Quan-ZhenLv,Ting-Jun-Hong Ni,Li-Ping Li,Tian Li,Da-Zhi Zhang*, Yuan-Ying Jiang*. A NewAntifungal Agent (4-phenyl-1, 3-thiazol-2-yl) Hydrazine Induces OxidativeDamage in Candida albicans. Front Cell Infect Microbiol. 2020;10:578956, 

21)  FeiXie#; Tingjunhong Ni#; Zichao Ding#; Yumeng Hao; Ruina Wang; Ruilian Wang; TingWang; Xiaoyun Chai; Shichong Yu; Yongsheng Jin; Yuanying Jiang*; Dazhi Zhang*.Design, synthesis, and in vitro evaluation of novel triazole analoguesfeaturing isoxazole moieties as antifungal agents. Bioorg Chem. 2020;101:103982,

22)  Ren-YiLu#; Ting-Jun-Hong Ni#; Jing Wu#; Lan Yan; Quan-Zhen Lv; Li-Ping Li; Da-ZhiZhang*; Yuan-Ying Jiang*. New Triazole NT-a9 Has Potent Antifungal Efficacyagainst Cryptococcus neoformans In Vitro and In Vivo. Antimicrob AgentsChemother, 2020;64(2)：e01628-19

23)  XinHuang#; Yu Liu#; Tingjunhong Ni#; Liping Li; Lan Yan; Maomao An; Dazhi Zhang*;Yuanying Jiang*. 11g, a Potent Antifungal Candidate, Enhances Candida albicansImmunogenicity by Unmasking β-Glucan in Fungal Cell Wall. Front Microbiol,2020;11:1324

24)  ZichaoDing#; Tingjunhong Ni#; Fei Xie#; Yumeng Hao; Shichong Yu; Xiaoyun Chai;Yongsheng Jin; Ting Wang; Yuanying Jiang*; Dazhi Zhang*. Design, synthesis, andstructure-activity relationship studies of novel triazole agents with strongantifungal activity against Aspergillus fumigatus. Bioorg Med Chem Lett,2020;30(4):126951