主持承担科研项目:

（1）国家自然科学基金面上项目（2024-2027）；

（2）国家自然科学基金面上项目（2019-2022）；

（3）中央高校基本科研业务费专项资金（2017-2018）；

（4）国家自然科学基金青年基金项目（2015-2017）；

（5）中国博士后基金项目2项（2014-2015；2017-2018）；

（6）中国博士后特别资助基金（2014-2015）；

（7）杨浦区博士后创新实践基地科研项目（2014-2016）。

在Advanced FunctionalMaterials、ACS Nano、AdvancedScience、Cell Reports、Biomaterials、ACS Applied Materials & Interfaces、NanoResearch等国际高水平杂志上发表SCI论文30余篇。近期代表性成果：

1 Lulu An, Yiqiong Liu, ZichenYang, Rongjie Li, Weimin Yin, Haiqing Dong, Yan Li*, YongyongLi*. Intracellular Delivery of CRISPR/Cas9 via Living Bacteria to BlockArginine Metabolic Reprogramming and Enhance Tumor Chemotherapy Sensitivity. AdvancedFunctional Materials, 2025, e04296.

2 Li Huang, Ying Luo, Le Kuai, XiaoyouZhang, Ying Zhang, Zichen Yang, Xiaoya Fei, Jiuyuan Sun, Yue Luo, Yuge Zhao,Tingting Xue, Weimin Yin, Jiao Chang, Jiankun Song, Yongyong Li*, Bin Li*, YanLi*. An approach for psoriasis of microneedle patch simultaneously targetingmultiple inflammatory cytokines and relapse related T cells. Biomaterials.2025, 318, 123120. 

3 Xiaoyou Zhang, Rongjie Li, Zichen Yang,Yanni Cai, Caoyi You, Hui Zhi, Shiyu Chen, Haiqing Dong, Weimin Yin, Lulu An, YongyongLi*, Yan Li*. Nano-mechanochemical synergistic approach to reprogramtumor-associated macrophages for tumor immunotherapy. J Control Release. 2025, 385,114062.

4 Zichen Yang, Yuge Zhao, Xiaoyou Zhang, LiHuang, Kun Wang, Jiuyuan Sun, Nana Chen, Weimin Yin, Shiyu Chen, Hui Zhi, LiangyiXue, Lulu An, Rongjie Li, Haiqing Dong, Jinfu Xu*, Yan Li*, Yongyong Li*. Nano-mechanicalImmunoengineering: Nanoparticle Elasticity Reprograms Tumor-AssociatedMacrophages via Piezo1. ACS Nano. 2024, 18(32), 21221-21235.

5 Zhang T, Yin W, Zhao Y, Huang L, Gu J,Zang J, Zheng X, Chang J, Sun J, Dong H, Li Y, Yan Li*. NOX2 Enzyme MimickingNano-Networks Regulate Tumor-Associated Macrophages to Initiate Both Innate andAdaptive Immune Effects. Adv Healthc Mater. 2023, e2302387.

6 Xiaoyi Ma, Bingbing Liu, LiminFan,Yiqiong Liu, Yuge Zhao, Tianbin Ren*, Yan Li*,Yongyong Li*. Native and engineered exosomes for inflammatory disease. Nano Research,2023, 16(5): 6991-7006.

7 Zhang T, Yang Y, Huang L, Liu Y, Chong G,Yin W, Dong H*, Li Yan*, LiYongyong. Biomimetic and Materials-Potentiated CellEngineering for Cancer Immunotherapy. Pharmaceutics, 2022, 14, 734.

8 Yan Li, Yi Han, Runping Su,Yiqiong Liu,Gaowei Chong, Dailin Xu, Ruiqing He, Ying Liu, Haiqing Dong,Donglu Shi,Yongyong Li*. Photosensitizer-laden Neutrophils Remotely Controlled for CancerImmunotherapy. Cell Reports, 2020, 33, 108499.

9 Yan Li, Lianghua He,Haiqing Dong, YiqiongLiu, Kun Wang, Ang Li, Tianbin Ren, Donglu Shi, YongyongLi*. Fever-inspiredImmunotherapy Based on Photothermal CpG Nanotherapeutics: The Critical Role ofMild Heat in Regulating Tumor Microenvironment. Advanced Science,2018,1700805,1.

10 Dou Du, Kun Wang, Ya Wen,Yan Li*,Yongyong Li*. PhotodynamicGraphene Quantum Dot: Reduction Condition RegulatedPhoto-activity and Size Dependent Efficacy. ACS Applied Materials &Interfaces, 2016, 8, 3287.