利用分子生物学、RNA测序、生物信息学和电生理等技术在转基因小鼠模型和疾病小鼠模型上研究神经发育与神经病理及药物发现，主要包括：

1.疼痛基因网络调控和躯体感觉神经元分化的分子机制研究，并筛选、发现抑制疼痛的药物。

2.疼痛传导环路及中枢痛敏的分子机制。

3.研究中脑多巴胺神经元（mDA）的存活、诞生数目调控的分子机制，探寻帕金森病的早期诊断biomarker和诊断方法。

1. 国家自然科学基金委，面上项目，32070977，调控中脑黑质多巴胺神经元诞生数目的分子机制研究，2021.01-2024.12，主持。

2. 国家自然科学基金委，面上项目，51971236，钛植入体对骨免疫和神经再生微环境的光致调控机制和效果研究，2020.01-2023.12，二级主持。

3. 国家自然科学基金委，面上项目，31871063，MiR-183-96在中枢神经系统中调制急性和神经病理性疼痛的作用及机制研究，2019.01-2020.12，主持,已完成。

4. 国家自然科学基金委，应急管理项目，31741057，利用基因敲除小鼠优选治疗神经病理性疼痛的候选微RNA靶点，2018.01-2018.12主持,已完成。

科研论文：

1. Yan Fu, Liting Sun, Fengting Zhu, Wei Xia, TingWen, Ruilong Xia, Xin Yu, Dan Xu*, Changgeng Peng*. Ectopic expression ofNav1.7 in spinal dorsal horn neurons induced by NGF contributed to neuropathicpain in a mouse spinal cord injury model. Front. Mol. Neurosci., 03 March 2023.Volume 16 - 2023

2.Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Ruilong Xia,Ting Wen, Wei Xia, Ran Qian, Fengting Zhu, Yuanying Liu, Zhicheng Tian, LameiLi, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou-Gang Xie, Changgeng Peng. Nav1.7 and Nav1.8 formsupramolecular active clusters with TRKB in mouse and human DRG neurons duringdevelopment of neuropathic pain. medRxiv 2022.11.05.22281929; doi: https://doi.org/10.1101/2022.11.05.22281929

3. LitingSun, Changgeng Peng, Elbert Joosten,Chi Wai Cheung, Fei Tan, Wencheng Jiang, and Xiafeng Shen. Spinal CordStimulation and Treatment of Peripheral or Central Neuropathic Pain: Mechanismsand Clinical Application. Neural Plast. 2021; 2021: 5607898.

4.Yong-Hui Zhang, Hao-Yu Hu, Yuan-Chang Xiong, Changgeng Peng, Li Hu, Ya-Zhuo Kong, Yu-Ling Wang, Jia-Bao Guo,Sheng Bi, Tie-Shan Li, Li-Juan Ao, Chu-Huai Wang, Yu-Long Bai, Lei Fang, ChaoMa, Lin-Rong Liao, Hao Liu, Yi Zhu, Zhi-Jie Zhang, Chun-Long Liu, Guo-En Fang,Xue-Qiang Wang. Exercise for Neuropathic Pain: A Systematic Review and ExpertConsensus. Front Med (Lausanne). 2021 Nov 24;8:756940.

5. Sun L, Xia R, Jiang J, Wen T, Huang Z,Qian R, Zhang M, Zhou M, Peng C.MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodiumchannels in spinal cord. Progress inNeurobiology, 2021 Jul;202:102024. (IF 11.68)

6. Li N, Zhou P, Tang H, He L, Fang X, ZhaoJ, Wang X, Qi Y, Sun C, Lin Y, Qin F, Yang M, Zhang Z, Liao C, Zheng S, Peng X,Xue T, Zhu Q, Li H, Li Y, Liu L, Huang J, Liu L, Peng C, Kaindl AM, Gecz J, Han D, Liu D, Xu K, Hu H. In-depthanalysis reveals complex molecular aetiology in a cohort of idiopathic cerebralpalsy. Brain. 2021 Jun 2: doi:10.1093/brain/awab209. (IF 13.5)

7. Zhou P, Qi Y, Fang X, Yang M, Zheng S,Liao C, Qin F, Liu L, Li H, Li Y, Ravindran E, Sun C, Wei X, Wang W, Fang L,Han D, Peng C, Chen W, Li N, KaindlAM, Hu H. Arhgef2 regulates neural differentiation in the cerebral cortexthrough mRNA m6A-methylation of Npdc1 and Cend1. iScience. 2021 May 24;24(6):102645. (IF 5.45)

8. Nouri P, Goetz S, Rauser B, Irmler M, Peng C, Trumbach D, Kempny C,Lechermeier C, Brybiok A, Dulugos A, Euchner E, Beckers J, Brodski C, KlumperC, Wurst W, Prakash N. Dose-dependent and subset-specific regulation ofmidbrain dopaminergic neuron differentiation by LEF1-mediated WNT1/b-cateninsignaling. Frontiers in Cell andDevelopmental Biology. 2020 Oct 26;8:587778. (IF 6.68)

9. Sun L#, Liu Y# and Peng C. Different Manners of Interplay between MicroRNAs and GenePrograms in Neuronal Specification. Journalof Cell Signaling. 2018, 3:4. DOI: 10.4172/2576-1471.1000193.

10. Peng C§，Furlan A,Zhang M, Su J, Lübke M， Lönnerberg P, Abdo H, Sontheimer J,Sundström E, Ernfors P2§.Termination of cell-type specification gene programs by miR-183 cluster determinesthe population sizes of low threshold mechanosensitive neurons. Development.2018 Sep 25;145(18):dev165613. (§共同通讯作者).

11. ZhangM, Su J, Adori C, Cinquina V, Malenczyk K, Girach F, Peng C, Ernfors P, Löw P, Borgius L, O, Watanabe M, M, Mitsios N, MulderJ, Harkany T*，Hökfelt T*. Ca2+-binding protein NECAB2facilitates inflammatory pain hypersensitivity. Journal Of Clinical Investigation. 2018 July 30.https://doi.org/10.1172/JCI120913.

12. YangS, Toledo E, Rosmaninho P, Peng C,Uhlén P, Castro D, Arenas E. A Zeb2-miR-200c loop controls midbraindopaminergic neuron neurogenesis and migration. Communications Biology volume 1, Article number: 75 (2018).

13. Peng C, Li L, Zhang M, Gonzales C,Parisien M, Belfer I, Usoskin D, Abdo H, Furlan A, Häring M, Lallemend F,Harkany T, Diatchenko L, Hökfelt T, Hjerling-Leffler J and Ernfors P. MiR-183cluster scales mechanical pain sensitivity by regulating basal and neuropathicpain genes. Science. 2017 Jun16;356(6343):1168-1171. （Science同期杂志上发表了Perspectivereview， F1000优秀论文）

14. Peng C,Li N,Ng YK,Zhang J,Meier F,Theis FJ,MerkenschlagerM, Chen W,Wurst W,Prakash N.A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3controls neural progenitor cell-cycle exit and differentiation. J Neurosci.2012 Sep 19;32(38):13292-308. （F1000优秀论文）

15. Peng C, Aron L, Klein R, Li M, Wurst W, Prakash N, and Le W. Pitx3is a critical mediator of GDNF-induced BDNF expression in nigrostriataldopaminergic neurons. J Neurosci. 2011 Sep;31, 12802-12815.

16. PengC, Fan S, Li X, Fan X, Ming M, Sun Z, Le W. Overexpression ofpitx3 upregulates expression of BDNF and GDNF in SH-SY5Y cells and primaryventral mesencephalic cultures. FEBSLett. 2007 Apr 3;581(7):1357-61. Epub 2007 Mar 2.

17. Li X, Peng C, Li L, Ming M,Yang D, Le W. Glial cell-derivedneurotrophic factor protects against proteasome inhibition-induced dopamineneuron degeneration by suppression of endoplasmic reticulum stress andcaspase-3 activation. JGerontol A Biol Sci Med Sci. 2007 Sep;62(9):943-50.

18. Yang, D., Peng, C., Li, X.,Fan, X., Li, L., Ming, M., Chen, S., and Le, W. Pitx3-transfected astrocytessecrete brain-derived neurotrophic factor and glial cell line-derivedneurotrophic factor and protect dopamine neurons in mesencephalon cultures. J Neurosci Res.2008 Nov; 86(15), 3393-3400.

19. Li X, Yang D, Li L, Peng C, Chen S, Le W. Proteasomeinhibitor lactacystin disturbs the intracellular calcium homeostasis of dopamineneurons in ventral mesencephalic cultures. Neurochem Int. 2007 Jun;50(7-8):959-65. Epub 2007 May 3.

发明专利

1.ANALGESICAND ANTIPRURITIC PHARMACEUTICAL COMPOSITION AND APPLICATION METHOD THEREFOR.2021329457,发明人设计人：彭长庚，孙立婷，夏瑞龙。已授权, 澳大利亚。

2.ANALGESICAND ANTIPRURITIC PHARMACEUTICAL COMPOSITION AND APPLICATION METHOD THEREFOR. 18/171，431, 发明人设计人：彭长庚，孙立婷，夏瑞龙。实审中, 美国。

3.ANALGESICAND ANTIPRURITIC PHARMACEUTICAL COMPOSITION AND APPLICATION METHOD THEREFOR. 3190205,发明人设计人：彭长庚，孙立婷，夏瑞龙。实审中, 加拿大。

4.ANALGESICAND ANTIPRURITIC PHARMACEUTICAL COMPOSITION AND APPLICATION METHOD THEREFOR. AMCZ-2311994026,EP 21857112.3, 发明人设计人：彭长庚，孙立婷，夏瑞龙。欧洲。

5.ANALGESICAND ANTIPRURITIC PHARMACEUTICAL COMPOSITION AND APPLICATION METHOD THEREFOR. AMCZ-2311994026,11202301295W, 发明人设计人：彭长庚，孙立婷，夏瑞龙。新加坡。

6.ANALGESICAND ANTIPRURITIC PHARMACEUTICAL COMPOSITION AND APPLICATION METHOD THEREFOR. AMCZ-2311994026,52300301268, 发明人设计人：彭长庚，孙立婷，夏瑞龙。日本。

7.ANALGESICAND ANTIPRURITIC PHARMACEUTICAL COMPOSITION AND APPLICATION METHOD THEREFOR. AMCZ-2311994026,10-2023-7006788, 发明人设计人：彭长庚，孙立婷，夏瑞龙。韩国。

8.《一种止痛止痒药物组合物及其应用方法》，专利号：ZL202010845095.2，发明人设计人：彭长庚，孙立婷，夏瑞龙。20200821. （已转让，已授权）

9. 《一种止痛止痒药物组合物及其应用方法》，专利申请号：PCT/CN2021/072071，发明人设计人：彭长庚，孙立婷，夏瑞龙。2021.1.15. （已转让）

10.《一种制备TrkB-Tomato小鼠的方法及其应用》专利申请号：202210052495.7，发明人设计人：彭长庚，解柔刚，孙立婷，夏瑞龙。2022.01.18. （已转让）