近5年，主要科研项目：

1.  上海市科委创新项目 (No.24SF1900902, 20万元) 注射用曲妥珠单抗HER2阳性乳腺癌应用示范项目(2024.12-2027.11) 项目负责人

2.  国家自然科学基金 (No.82273922, 52万元)铁死亡介导的STAT4激活在腹主动脉瘤发生发展的作用及机制研究(2023.01-2026.12)  项目负责人

3.  上海市科委“科技创新行动计划”(No. 21S11901200, 20万) 肌醇六磷酸盐磷酸激酶3(IP6K3)在非酒精性脂肪性肝病中的作用及机制研究(2021.08-2024.07) 项目负责人

4.    国家自然科学基金 (No. 81973312, 55万元)  CTRP1抑制NIK/非经典NF-kB2介导的IL-23/IL-17通路延缓腹主动脉瘤发生发展的作用及机制(2020.01-2023.12) 项目负责人

5.   上海市协同创新集群(No.2019CXJQ03，99.8万)  精准医学临床实践中的关键分子检测技术研发和转化应用(2019.1-2023.12) 子课题负责人

近5年，通讯作者文章：

1.      Shi Y, Zhao Y, Sun SJ, Lan XT, Wu WB, Zhang Z, Chen YX, Yan YY, Xu YP, Li DJ*, Fu H*, Shen FM*. Targeting GPX4 alleviates ferroptosis and retards abdominal aortic aneurysm formation. Biochem Pharmacol. 2025; 234:116800.

2.      Sun DY, Wu WB, Wu JJ, Shi Y, Xu JJ, Ouyang SX, Chi C, Shi Y, Ji QX, Miao JH, Fu JT, Tong J, Zhang PP, Zhang JB, Li ZY, Qu LF*, Shen FM*, Li DJ*, Wang P*. Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence. Nat Commun. 2024; 15: 1429.

3.      Sun SJ, Jiao XD, Chen ZG, Cao Q, Zhu JH, Shen QR, Liu Y, Zhang Z, Xu FF, Shi Y, Tong J, Ouyang SX, Fu JT, Zhao Y, Ren J, Li DJ*, Shen FM*, Wang P*. Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation. Nat Commun. 2024; 15: 6640.

4.      Zhao Y, Shen QR, Chen YX, Shi Y, Wu WB, Li Q, Li DJ, Shen FM*, Fu H*. Colchicine protectsagainst the development of experimental abdominal aortic aneurysm. Clin Sci(Lond). 2023;137:1533-1545.

5.      Li ZC, Xu FF, Fu JT, Ouyang SX, Cao Q, Yan YY, Li DJ, Shen FM*, Ni M*. Sting mutation attenuates acetaminophen-induced acute liver injury by limiting NLRP3 activation. Int Immunopharmacol. 2023; 125: 111133.

6.      Chi C, Fu H, Li YH, Zhang GY, Zeng FY, Ji QX, Shen QR, Wang XJ,Li ZC, Zhou CC, Sun DY, Fu JT, Wu WB, Zhang PP, Zhang JB, Liu J, Shen FM*, Li DJ*, Wang P*. Exerkinefibronectin type-III domain-containing protein 5/irisin-enriched extracellularvesicles delay vascular ageing by increasing SIRT6 stability. EurHeart J. 2022; 43: 4579-4595.

7.     Fu H, Shen QR, Zhao Y, Ni M, Zhou CC, Chen JK, Chi C, Li DJ, Liang G*, Shen FM*. Activatingalpha7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosismediated by NLRP3 inflammasome. Acta Pharmacol Sin. 2022; 43: 2589-2595.

8.     Tong J, Li DJ, Meng H, Sun DY, Lan XT, Ni M, Ma JW, Zeng FY,Sun SJ, Fu JT, Li GQ, Ji QX, Zhang GY, Shen QR, Wang YY, Zhu JH, Zhao Y, WangXJ, Liu Y, Ouyang SX, Sheng CQ*, ShenFM*, Wang P*. Targeting a novel inducible GPX4 alternative isoform toalleviate ferroptosis and treat metabolic-associated fatty liver disease. Acta Pharm Sin B. 2022; 12: 3650-3666.

9.     Zhou CC, HeYQ, Qiu YS, Ni CX, Shen FM*, Li DJ*. Zinc supplementation ameliorates sorafenib-induced cognitive impairment throughROS/JNK signaling pathway. Biol Trace Elem Res. 2022; 201: 324-337.

10.     Zhou CC, WangXJ, Li ZC, Lu WJ, Zhang YT, Shen FM*, Li DJ*.  Lead exposure in developmental ages promotes Aβ accumulation by disturbing Aβ transportation in blood-cerebrospinal fluid barrier/blood-brainbarriers and impairing Aβ clearance in the liver. Biol Trace Elem Res. 2021; 208: 111642.

11.     Ni M, Zhao L, Zhang WJ, Ma JW, Zhang GY, Cui DM, Wang K, Fei YB, Gao L*, Shen FM*. Pharmacokinetics of colistin in cerebrospinal fluidafter intraventricular administration alone in intracranial infections. IntJ Antimicrob Agents 2021; 57: 106281.

12.     Zhou CC, Fu H, Zhang GY, Ma JW, Ni M, Li DJ, Shen FM*, Huang F*. Effects of low-level mercuryexposure on brain-derived neurotrophic factor in preschool children. Ecotoxicol Environ Saf 2021; 208: 111642.

13.     Jiang YJ, Sun SJ, Cao WX, Lan XT, Ni M, Fu H, Li DJ, Wang P*, Shen FM*. Excessive ROSproduction and enhanced autophagy contribute to myocardial injury induced bybranched-chain amino acids: Roles for the AMPK-ULK1 signaling pathway and α7nAChR. BBA-Mol Basis Dis. 2021; 1867:165980.