近五年负责的课题：

1.国家自然科学基金项目（重大研究项目）（205万）

神经干细胞与胶质细胞释放的外泌体在介导衰老与神经退行性病变中的作用及其分子机制研究

2.科技部 国家重大科学研究计划（1500万）

诱导性前脑神经祖细胞体内微环境的组分解析、条件优化和功能模拟

3.国家自然科学基金委员会（海外及港澳学者合作研究基金）220万

巨噬细胞及神经小胶质细胞在中枢神经退行性疾病中的作用及机制 (1-2)

中脑多巴胺神经元前体细胞的转分化及其治疗帕金森疾病的研究 (3-6)

4.国家自然科学基金委员会（重点项目）（293万）

谷氨酰胺酶C亚型介导的小胶质细胞激活在阿尔兹海默病神经炎症的机制解析

5.课题组国家自然科学基金项目15项

学术论文：(总引用次数:9600余次; h-index: 58; i10-index: 135)

2022

1.   Yuan Pǂ, Li Jǂ, Liu J, Liu H, Gong S,Wang L, Liu J, Li C, Wang Y,Xia X,Zheng JC* (2022). Cognitive dysfunction inpatients with pulmonary hypertension. Am J Resp Crit Care. 2022; Accepted.(IF=30.528)

2.   XiaX, Wang Y, Qin Y, Zhao S, Zheng JC* (2022).Exosome: a novel neurotransmission modulator or non-canonical neurotransmitter?Ageing Research Reviews. doi:10.1016/j.arr.2022:74: 101558

3.   Fu S, Chen H, Yang W, Xia X*, Zhao S,Xu, X, Ai P, Cai Q, Li X, Wang Y, Zhu J, Zhang B*, Zheng JC* (2022).ROS-targeted Depression Therapy via BSA-incubated Ceria Nanocluster. NanoLetters. 2022; May 18. doi:10.1021/acs.nanolett.2c01334. Online ahead of print. PMID: 35583518

4.   Fu Sǂ, Chen Hǂ, Zhao Sǂ, Yang W, XiaX*, Xu, X, Liang Z, Feng X, Wang Z, Ai P, Ding L, Cai Q, Wang Y, Zhang Y, ZhuJ, Zhang B*, Zheng JC* (2022). Insulin-incubated palladium clusterspromote recovery after brain injury. J Nanobiotechnology. 2022; (In Press).

5.   Ding Lǂ, Wu H, Wang Y, Li Y, Xia X*, ZhengJC* (2022). m6A reader Igf2bp1 regulates the inflammatory responses ofmicroglia by stabilizing Gbp11 and Cp mRNAs. Front. Immunol. 2022; 2022 Apr 29;13:872252. doi: 10.3389/fimmu.2022.872252. eCollection2022.PMID: 35572575

6.   Ma Z, Zheng JC, Li T, Xie Z, Kang L (2022). Janus KinaseMediates Faster Recovery From Sevoflurane Anesthesia Than Isoflurane Anesthesiain the Migratory Locusts. Front Physiol. 2022 Mar 30;13:806746. doi: 10.3389/fphys.2022.806746.eCollection 2022.PMID: 35431999

7.   Gao Gǂ,Li Cǂ, Zhu Jǂ, Sheng S, Liang Z, Fu S, Li X, Sun Y, Wang Y, Feng X, Xia X*, ZhengJC* (2022). Induced neural stem/progenitor cell-derived extracellularvesicles promote recovery post stroke. Clinical and Translational Medicine;(In press). 

8.   Sun Yǂ,Xia Xǂ, Basnet D, Zheng JC*, Huang J*, Liu J* (2022). Mechanisms offerroptosis and emerging links to the pathology of neurodegenerative diseases. FrontAging Neurosci. 2022; (In press).                                                                                                                                                                          

9.   Liu Jǂ, Feng Xǂ, Wang Y, Xia X*, Zheng JC*(2022). Astrocytes: GABAceptive and GABAergic cells in the brain. Front CellNeurosci. 2022; (In press).                                   

10. LiuJ, Ding L, Yang X, Liu Y, Wang Y, Li C, Gao G, Zhao S, Sheng S, Xia X*, ZhengJC* (2022). Exosomes mediate APP dysregulation via APP-miR-185-5p axis. Frontiersin Cell and Developmental Biology. doi: 10.3389/fcell.2022.793388

11. XiaX*, Wang Y, Zheng JC* (2022). The microRNA-17~92 family as a keyregulator of neurogenesis and potential regenerative therapeutics ofneurological disorders. Stem Cell Review & Report.doi: 10.1007/s12015-020-10050-5.    

12.Sun X, Zhang M, Lu Z, Zhang Z, Zheng JC,Cheng L, Zeng L, Qian Y, Huang L (2022). Turnover intention andrelated factors among resident physicians in China under the standardisedresidency training programme: a cross-sectional survey. BMJ Open. 2022 Apr 11;12(4):e061922. doi:10.1136/bmjopen-2022-061922.PMID: 35410941

13. PanJ, Sheng S, Ye L, Xu X, Ma Y, Feng X, Qiu L, Fan Z, Wang Y*, Xia X*, ZhengJC* (2022).  Extracellular vesiclesderived from glioblastoma promote proliferation and migration of neuralprogenitor cells via PI3K-Akt pathway. Cell Communication & Signaling.2022; 20:7  doi:10.1186/s12964-021-00760-9

2021

14. Zheng X, Wang X, Zhang W, Li R,Liu M, Xu FY, Li YX*, Zheng JC*, Nie ZY* (2021). ExtendedApplication of Digital Clock Drawing Test in the Evaluation of Alzheimer’sDisease Based on Artificial intelligence and the Neural Basis. Current AlzheimerResearch. doi: 10.2174/1567205018666211210150808.

15. Ji C, Tang Y, Zhang Y, Li C,Liang H, Ding L, Xia X, Xiong L, Qi XR*, Zheng JC* (2021). Microglialglutaminase 1 deficiency mitigates neuroinflammation associated depression. BrainBehavior and Immunity. doi:10.1016/j.bbi.2021.10.009.

16. Wang J, Zhang W, Zheng X, NieZ, Li YX*, Zheng JC* (2021). Exploration and progress of new cognitiveassessment techniques in the diagnosis of dementia. Journal of ChongqingMedical University. doi:10.13406/j.cnki.cyxb.002927.(in Chinese)

17. Ma Y, Xu X, Li C, Wang Y, ZhuJ, Xia X*, Zheng JC*(2021). Inducedneural progenitor cell-derived extracellular vesicles promote neural progenitorcell survival via extracellular signal- regulated kinase pathway. CNSNeuroscience and Therapeutics. doi: 10.1111/cns.13744.

18. Liu J, Ai P, Sun Y, Yang X,Li C, Liu Y, Xia X, Zheng JC*. Propofol inhibits microglial activationvia miR-106b/Pi3k/Akt axis. Front. Cell. Neurosci.2021; In Press.

19. Liu M, Nie Z, Li R, Zhang W,Huang L, Wang J, Xiao W, Zheng JC*, Li Y*(2021).Neural Mechanism of Repeated Transcranial Magnetic Stimulation to EnhanceVisual Working Memory in Elderly Individuals With Subjective Cognitive Decline.Front. Neurol.  2021; 12:1106.doi:10.3389/fneur.2021.665218.

20. Yuan P, Ding L, Chen H, WangY, Li C, Zhao S, Yang X, Ma Y, Zhu J, Qi X, Zhang Y, Xia X*, Zheng JC* (2021). Neural stem cell-derived exosomes regulateneural stem cell differentiation through miR-9-Hes1 axis. Front. Cell Dev.Biol. 2021; 9:601600. doi: 10.3389/fcell.2021.601600.

21.Liu S, Müller S, Dolan RJ, Zhao X, Zheng JC, Heinz A.(2021). Opportunities, risks and challenges in global mental health andpopulation neuroscience: a case of Sino-German cooperation Eur ArchPsychiatry Clin Neurosci. 2021 Sep;271(6):1027-1034. doi:10.1007/s00406-020-01176-1. Epub 2020 Jul 29.PMID: 32729097 

22. Xia X*, Wang Y, Zheng JC* (2021). COVID-19 and Alzheimer's disease: how onecrisis worsens the other. Transl. Neurodegener. 2021; 10(1):15. doi:10.1186/s40035-021-00237-2.

23. Xia X*, Wang Y, Zheng JC* (2021). Emerging roles of extracellular vesicles inmediating RNA virus infection. Fundamental Research. 2021; 2(1):179-185.doi: 10.1016/j.fmre.2021.02.005.

24.Sun X, Zhao X, Zhang H, Li J, Jiang C, Chen Y, Zheng JC (2021). MedicalSchool Affiliation Accelerates the Development of Community Health Centers inChina. Ann Fam Med. 2021Mar-Apr;19(2):178. doi: 10.1370/afm.2657.PMID: 33685880

25. Zhao S ,Sheng S, Wang Y, Ding L, Xu X, Xia X* and Zheng JC*(2021).Astrocyte-derived extracellular vesicles: a double-edged sword in centralnervous system disorders. Neurosci Biobehav Rev.doi:10.1016/j.neubiorev.2021.02.027.

26. Xia X, Yuan P, Liu Y, Wang Y, Cao W, Zheng JC* (2021). Emerging roles of extracellular vesicles in COVID-19, adouble-edged sword? Immunology. doi: 10.1111/imm.13329.

2020

27. Yuan P, Ai P, LiuY, Ai Z, Wang Y, Cao W, XiaX* and Zheng JC* (2020). Safety, Tolerability, and Immunogenicity ofCOVID-19 Vaccines: A Systematic Review and Meta-Analysis. medRxiv. doi:10.1101/2020.11.03.20224998.

28. Ding L ,Xu X, Li C , Wang Y*, Xia X*, Zheng JC* (2020). Glutaminase inmicroglia: a novel regulator of neuroinflammation. Brain Behav Immun.doi:10.1016/j.bbi.2020.11.038.

29. Dalfo D, Ding Y,Liang Q, Fong A, Cipriani PG, Piano F, Zheng JC, Qin Z, Hubbard EJA*.A Genome-Wide RNAi Screen for Enhancers of a Germline Tumor Phenotype Caused byElevated GLP-1/Notch Signaling in Caenorhabditis elegans. G3 (Bethesda).doi:10.1534/g3.120.401632.

30. Qiu L, Zhang M, Zhang S, TangY,  Zhang Y, Li C, Wang Y, Jiang L* and Zheng JC*(2020).  Activation of CXCR7 promotes endothelial repair and reduces the carotid atherosclerotic lesionsthrough inhibition of pyroptosis signaling pathways. Aging Cell.doi:10.1111/acel.13205.

31. Xia X*, Wang Y, ZhengJC* (2020). ThemicroRNA-17~92 family as a key regulator of neurogenesis and potentialregenerative therapeutics of neurological disorders. Stem Cell Reviews andReports. doi: 10.1007/s12015-020-10050-5.

32. Xia X, Li C, WangY, Deng X, Ma Y, Ding L, Zheng JC* (2020).Reprogrammed astrocytes display higher neurogenic competence, migration abilityand cell death resistance than reprogrammed fibroblasts. Translational Neurodegeneration. doi: 10.1186/s40035-020-0184-6.

33. Gao G, Li C, Zhu J, Wang Y,Huang Y, Zhao S, Sheng S, Song Y, Ji C, Li C, Yang X, Ye L, Qi X, Zhang Y, XiaX* and Zheng JC* (2020) Glutaminase1 Regulates Neuroinflammation After Cerebral Ischemia Through EnhancingMicroglial Activation and Pro-inflammatory Exosome Release. Front. Immunol.11:161. doi: 10.3389/fimmu.2020.00161

34. Zhang Y, Lu P, Liang F, LiufuN, Dong Y, Zheng JC* and Xie Z*(2020). Cyclophilin D Contributes to Anesthesia Neurotoxicity in the DevelopingBrain. Front. Cell Dev. Biol. 7:396. doi: 10.3389/fcell.2019.00396.

35. Chen X, Guo J, Huang Y, LiuS, Huang Y, Zhang Z, Zhang F, Lu Z, Li F, Zheng JC*, Ding W*. (2020).Urban airborne PM2.5-activated microglia mediate neurotoxicity throughglutaminase-containing extracellular vesicles in olfactory bulb. EnvironPollut. 264:114716. doi: 10.1016/j.envpol.2020.114716.

36. Adams AP, Albin SR, Amunts K, Asakawa T, Bernard A, Bjaalie JG,Chakli K, Deshler JO, De Koninck Y, Ebell CJ, Egan G, Hale ME, Häusser M, Jeong SJ, Illes J, Lanyon L, Li P, Li Y,Magistretti P, McMahon A, Montojo C, Ohtsuka T, Okabe S, Okano H, Pei G, PougetA, Reindorp J, Richards LJ, Rommelfanger KS, Sajda P, Scobie KN, SuhPG, Tanaka K, Thiels E, Valdes-Sosa PA, Welchman AE, White S, Wilson G, YusteR, Zhang X, Zheng JC (2020). International Brain Initiative: An Innovative Framework forCoordinated Global Brain Research Efforts. Neuron. 2:105.doi:10.1016/j.neuron.2020.01.002.

37. LiuS, Müller S, Dolan RJ, Zhao X, Zheng JC, Andreas Heinz.(2020). Opportunities, risks and challenges in global mental health andpopulation neuroscience: a case of Sino-German cooperation. Eur ArchPsychiatry Clin Neurosci. doi:10.1007/s00406-020-01176-1.

38. Fu S, Wang Y, XiaX*, Zheng JC* (2020). Exosomeengineering: current progress in cargo loading and targeted delivery. NanoImpact. doi:10.1016/j.impact.2020.100261.

39. Liu Z , ZhengJC,Tang W. Special Issue on Advanced Diagnosis and Therapy for Major Diseases andInjuries. Nano LIFE. 2020:2002001. doi: 10.1142/S1793984420020018.

主要科技奖励：

1. 2008年，美国内布拉斯加州立大学医学中心杰出科学家奖（UNMC Outstanding Scientist Award）

2. 2005年，美国内布拉斯加州立大学医学中心约瑟夫·吉尔摩(青年)科学家奖（UNMC Joseph P. Gilmore Outstanding Investigator Award）

主要专利：

获国际专利1项，国内专利2项：

1. “U.S. Application No. 15/503,649 - Methods and Compositions forSelective Generation of Dopaminergic Precursors (VP 160351-010300)”

2.A method for detectingaxon growth orientation of cortical neurons and its application

3. A method for detectingmigration polarization of primary neural stem cells and its application