1、国家自然基金面上项目，32271058，臂旁核介导的慢性痛与睡眠障碍共病的神经细胞和神经环路机制研究，2023/01-2026/12，在研，项目负责人

2、纳米前沿专项, 2021YFA1201400,课题：精准电磁调控神经通路的生物物理机制,所属项目：基于磁性微纳器件的退行性骨科疾病电磁治疗技术及临床研究，2022/01-2026/12，在研，骨干

3、上海市自然基金面上项目，21ZR1468600，烟酰胺腺嘌呤二核苷酸(NAD+)对骨癌痛的镇痛作用及其神经机制的研究，2021/07-2024/06，在研，项目负责人

4、国家重点研发计划，2019YFA0110301，干细胞命运决定的免疫因素及调控，2019/10-2023/12，在研，骨干

5、国家自然科学基金面上项目，31571086，PTEN在初级感觉神经元水平对痒觉的调控作用及其机制研究，2016/01-2019/12，已结题，项目负责人

6、上海市科委动物专项，15140904500，慢性神经病理性痒小鼠模型的建立和鉴定， 2015/09-2017/07，已结题，项目负责人

7、国家自然科学基金面上项目，31271182，脑干NE能和5-HT能神经元对急慢性痒的下行调控，2013/01-2016/12，已结题，项目负责人

8、科技部重大专项，2012CB966904，体内间充质干细胞自我更新、分化及其调控相关组织干细胞的机制研究，2012.1-2016.12，已结题，骨干

9、上海市浦江人才项目，12PJ1408800，脑干单胺能神经元对急慢性痒的下行调控，2012.9-2014.7，已结题，项目负责人

10、上海市自然基金面上项目，12ZR1434300，以光遗传学方法研究脑干去甲肾上腺素能神经元对急慢性痒的调控作用及其机制，2012/09-2015/07，已结题，项目负责人

11、上海市卫生局面上项目，抑炎因子IL-10对炎症痛的镇痛作用及其机制研究20114173，2011/09-2014/07，已结题，项目负责人

12、同济大学中央高校基金，急慢性痒的脊髓神经机制，1500219072，2013/01-2014/12，已结题，项目负责人

13、国家自然科学基青年上项目，30600171，大鼠前扣带皮层对急慢性痛的下行调控， 2007/01-2009/12，已结题，项目负责人

代表性文章 (#共同第一作者；*通讯/共同通讯作者)

Jia X, Li ZY, Shen XF, Zhang Y, Zhang L (张力), Zhang L（张玲）* High-intensity swimming alleviates nociception and neuroinflammation in a mouse model of chronic postischemia pain by activating the resolvin E1-chemerin receptor 23 axis in the spinal cord. Neural Regen Res,2023. 18(11):2535-2542.

Zhu YB, Wang Y, Hua XX, Xu L, Liu MZ, Zhang R, Liu PF, LiJB, Zhang L*, MuD*. PBN-PVT projections modulate negative affective states in mice. Elife. 2022;11.（Comment on：ChenG, Chen Z, Zhu Y. How the brain processes negative emotions. Elife. 2022;11）

Xu L, Liu MZ, Yang YY, Wang Y, Hua XX, Du LX, Zhu JY, Shen Y, Wang YQ, Zhang L, Mi WL*, Mu D*. Geraniol enhances inhibitory inputs to the paraventricular thalamic nucleus and induces sedation in mice. Phytomedicine. 2022;98:153965.

Liu PF, Wang Y, Xu L, Xiang AF, Liu MZ, Zhu YB, Jia X,Zhang R, Li JB, Zhang L*, MuD*. Modulation of itch and pain signals processing in ventrobasal thalamus bythalamic reticular nucleus. iScience. 2022;25(1):103625.

Liang Y, Shi W*, Hu DD, Xiang AF, Zhang L* (2021) Protocol for Recording the Discharge of Locus Coeruleus Neurons in Free-moving Mice during Different Sleep-Wake Stages. STAR Protocol, Dec 10.

Feng Q, Xu X, Wei C, Li Y, Wang M, Lv C, Wu J, DaiY, Han Y, Lesniak M, Fan H, Zhang L*, Cheng Y*（2021）TheDynamic Interactions between Nanoparticles and Macrophages Impact Their Fate inBrain Tumors. SMALL Oct12; e2103600

Wang Y, XuL, Liu MZ, Hu DD, Fang F, Xu DJ, Zhang R, Hua XX, Li JB, Zhang L, Huang LN, Mu D *.（2021）Norepinephrine modulates wakefulness via alpha1 adrenoceptors in paraventricular thalamic nucleus. iScience.24(9):103015.

Liang Y, ShiW, Xiang AF, Hu DD, Wang Lie-Cheng*, Zhang L*. (2021) The NAergic locus coeruleus-ventrolateral preoptic area neural circuit mediates rapid arousal from sleep. Current Biology, Jul 8;S0960-9822(21)00826-5. 

Jia X, Dai MH, Ren AJ, Wang TT, Zhang WJ*, Zhang L*(2021). ZBTB20 in Nociceptive Neurons of the Trigeminal Ganglia Regulates Pruritus. Front Med (Lausanne), Mar 4;8:626554.

Sheng HY, Lv SS, Cai YQ, Shi W, Lin W,Liu TT, Lv N, Cao H, Zhang L, ZhangYQ*  Activation of ventrolateral orbital cortex improves mouse neuropathicpain-induced anxiodepression. JCI Insight, 2020 Oct 2; 5(19):e133625

Zang KK, Xiao X, Chen LQ, Yang Y, Cao QL, Tang YL, Lv SS, Cao H, Zhang L, Zhang YQ* (2020). Distinct Function of Estrogen Receptors in the Rodent Anterior Cingulate Cortex in Pain-related Aversion. Anesthesiology, Jul;133(1):165-184

 Wang TT, Xu XY, Lin W, Hu DD, Shi W, Jia X, Wang H, Song NJ, Zhang YQ, Zhang L*. Activation of Different Heterodimers of TLR2 Distinctly Mediates Pain and Itch. Neuroscience.2020;429:245-255.

 Huang K#, Hu DD#, Bai D#, Wu ZY, ChenYY, Zhang YJ, Lv X, Wang QX*，Zhang L* (2018) Persistent ERK activation by the histamine H4 receptor in spinal neurons underlies chronic itch. J Invest Dermatol 138(8):1843-1850.

 Jiang GY, Dai MH, Huang K, Chai GD, Chen JY, Chen L, Lang B, Wang QX, Clair DS, McCaig C, Ding YQ*, Zhang L* (2015)Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch. Sci Rep Aug 7:5：12781

Zhang L*, Jiang GY, Song NN, Huang Y, Cen JY, Wang QX, Ding YQ * (2014) Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord. Mol Brain 2014, 7:25

 Hu L, Lan W, Guo H, Chai GD, Huang K, Zhang L, Huang Y, Chen XF, ZhangL, Song NN, Chen L, Lang B, Wang Y, Wang QX, Zhang JB, McCaig C, Xu L, Ding YQ*. A mouse line for inducible andreversible silencing of specific neurons. Mol Brain 2014, 7:68

 Huang Y, Song NN, Lan W, Zhang Q, Zhang L, Zhang L, Hu L, Chen JY, Zhao CJ, Li L, Xu L, Ding YQ*. (2013) Sensory input isrequired for callosal axon targeting in the somatosensory cortex. Mol Brain.6:53.

 Liu T, Berta T, Xu ZZ, Park CK, Zhang L, Lu N, Liu Q, Liu Y, Gao YJ, Liu YC, Ma Q, Dong X, Ji RR*（2012）TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest122:2195-2207.

 Zhang L*, Xue ZZ, Park JY, Ji RR*(2011). Distinct role of TNF receptor type I and type II in regulating inflammatory pain and synaptic plasticity in spinal cord neurons. Pain,152:419-27.

 Xu ZZ#, Zhang L#, Liu T, Park JY, Berta T, Yang R, Serhan CN*, & Ji RR*(2010). Resolvins Attenuate Inflammatory Pain via Central and Peripheral Actions. NatMed.16:592-597.

 Liu y#, Samad1 OA#, Zhang L, Duan B, Tong QC, Lopes C, Ji RR, Lowell B, and Ma QF* (2010).VGLUT2-dependentglutamate release from nociceptors is required to sense pain and suppress itch. Neuron. 68:543-56.

 Gao YJ, Zhang L, Ji RR* (2010). Spinal injection of TNF-α-activated astrocytes induces mechanical allodynia, a cardinal symptom of chronic pain, by releasing monocyte chemoattractant protein-1 to produce central sensitization. Glia.58:1871-80.

 ZhangL*, Zhao ZQ (2010). Plasticity changes of neuronal activities In central lateral nuclei by stimulation of the anterior cingulate cortex. Brain Res Bull 81:574-578.

 Gao YJ, Zhang L, Samad M, Suter M, Kawasaki Y, Xu ZZ, Park JY, Lind AL, Ma QF, Ji RR* (2009) JNK-induced MCP-1 production inspinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci 29:4096-4108.

 Kawasaki Y#, Zhang L#, Cheng JK, Ji RR* (2008) Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta,i nterleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci 28: 5189-5194.

 Zhang L, Zhang YQ, Zhao ZQ* (2005). Anterior cingulate cortex contributes to the descending facilitatory modulation of pain via dorsal reticular nucleus. Eur J Neurosci 22:1141-8.

2022 同济大学优秀博士后指导教师

2020 同济大学高水平科研能力奖

2019 同济大学研究生论文优秀指导教师

2014-2016 同济大学本科生学科竞赛优秀指导教师

2014 指导同济大学本科生《痒共情行为的中枢神经机制》获“第三届全国大学生基础医学创新论坛暨实验设计大赛”一等奖

2007 获疼痛基础研究与临床调控国际研讨会优秀论文奖

2015-至今同济大学医学院基础整合课程《神经系统》负责人 （临床医学本科生）

2019-2022 早期科研训练-实验动物与动物实验 （临床医学本科生）

2011-2015 神经生物学(临床医学本科生)

2011-2015 神经生物学（研究生）

2011-2015 人体解剖学-中枢神经解剖(临床医学本科生)

2011-2015 MBBS中枢神经解剖（留学生）

2015-至今 MBBS组织胚胎学神经系统 (留学生)

2017-至今 MBBS医学导论-组织胚胎学（留学生）