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二级教授、博士生导师、同济大学医学院党委书记、基础医学专业负责人和学科负责人。国务院特殊津贴专家、获国家杰出青年科学基金资助、入选国家百千万人才工程，兼授“有突出贡献中青年专家”、教育部“新世纪优秀人才”支持计划、上海市优秀学术带头人计划。担任中国细胞生物学会细胞治疗研究与应用分会委员、中国细胞生物学会医学细胞生物学分会委员、中国生理学会理事、上海市解剖学学会副理事长。《Fundamental Research》《Neurochem Res》《中华细胞与干细胞杂志》编委。长期从事人神经发育与神经再生研究，通过揭示人神经发育基本原理指导人多能干细胞体外神经定向分化，从而获得和疾病治疗相关的功能性神经细胞类型，并研究这些细胞的替代治疗前景。以通讯/第一作者在《Nature》、《Cell》、《Cell Stem Cell》、《Cell Research》、《The EMBO Journal》、《Cell Death and Differentiation》、《Development》、《Stem Cell Reports》等国际知名杂志发表SCI论文20余篇，引用4000余次；申请或授权专利8项，参编专著3部；作为首席科学家主持国家973重大科学研究计划和国家重点研发计划。
1. 国家自然科学基金重点项目，低免疫原性人多能干细胞体外谱系分化潜能与体内移植有效性探究，2023-2027年, 主持；
2. 国家杰出青年科学基金, 神经发育与神经再生，2021-2025年，主持。
1. Chen, Y#., Zhou, Y#., Zhou, Z., Fang, Y., Ma, L., Zhang,X*., Xiong, J*., and Liu, L*. (2023) Hypoimmunogenichuman pluripotent stem cells are valid cell sources for cell therapeutics withnormal self-renewal and multilineage differentiation capacity. StemCell Res Ther 14, 11. https://www.ncbi.nlm.nih.gov/pubmed/36691086.
2. Chen, X#., Du, Y#., Broussard, G. J#., Kislin, M., Yuede, C. M., Zhang, S., Dietmann, S., Gabel, H., Zhao, G.,Wang, S. S*., Zhang, X*., and Bonni, A*. (2022) Transcriptomicmapping uncovers Purkinje neuron plasticity driving learning. Nature 605, 722-727. https://www.ncbi.nlm.nih.gov/pubmed/35545673.
3. Ma, L., Du, Y., Xu, X., Feng, H., Hui, Y., Li, N.,Jiang, G., Zhang, X*., Li, X*., and Liu, L*. (2022) beta-CateninDeletion in Regional Neural Progenitors Leads to Congenital Hydrocephalus inMice. Neurosci Bull 38, 81-94. https://www.ncbi.nlm.nih.gov/pubmed/34460072.
4. Ma, L#., Du, Y#., Hui, Y#., Li, N., Fan, B., Zhang, X., Li, X., Hong, W., Wu, Z., Zhang, S., Zhou,S., Xu, X., Zhou, Z., Jiang, C., Liu, L., and Zhang, X*. (2021) Developmental programming and lineage branching of early humantelencephalon. EMBO J 40, e107277. https://www.ncbi.nlm.nih.gov/pubmed/34558085.
5. Zhou, Z#., Ma, L#*., and Zhang, X*. (2021) Protocol forgenome-scale CRISPR screening in engineered lineage reporter hPSCs to studycell fate determination. STAR Protoc 2, 100548. https://www.ncbi.nlm.nih.gov/pubmed/34095862.
6. Xu, X#., Du, Y#., Ma, L#., Zhang, S., Shi, L., Chen, Z., Zhou, Z., Hui, Y., Liu, Y., Fang, Y., Fan,B., Liu, Z., Li, N., Zhou, S., Jiang, C., Liu, L*., and Zhang,X*. (2021) Mapping germ-layer specification preventing genes in hPSCs viagenome-scale CRISPR screening. iScience 24, 101926. https://www.ncbi.nlm.nih.gov/pubmed/33385119.
7. Shi, L#., Li, W#., Liu, Y., Chen, Z., Hui, Y., Hao, P., Xu, X., Zhang, S., Feng, H., Zhang,B., Zhou, S., Li, N., Xiao, L., Liu, L*., Ma, L*., and Zhang, X*. (2020) Generation ofhypoimmunogenic human pluripotent stem cells via expression of membrane-boundand secreted beta2m-HLA-G fusion proteins. Stem Cells 38, 1423-1437. https://www.ncbi.nlm.nih.gov/pubmed/32930470.
8. Liu, L#., Chen, Z#., Zhang, X#., Li, S#., Hui, Y., Feng, H., Du, Y., Jin, G*., Zhou, X*., and Zhang, X*. (2019) Protection of ZIKVinfection-induced neuropathy by abrogation of acute antiviral response in humanneural progenitors. Cell Death Differ 26, 2607-2621. https://www.ncbi.nlm.nih.gov/pubmed/30952992.
9. Ma, L#., Wang, Y#., Hui, Y., Du, Y., Chen, Z., Feng, H., Zhang, S., Li, N., Song, J., Fang,Y., Xu, X., Shi, L., Zhang, B., Cheng, J., Zhou, S., Liu, L., and Zhang, X*. (2019) WNT/NOTCH Pathway Is Essential for theMaintenance and Expansion of Human MGE Progenitors. Stem Cell Reports 12,934-949. https://www.ncbi.nlm.nih.gov/pubmed/31056478.
10. Wang, Y#., Xu, C#., Ma, L#., Mou, Y., Zhang, B., Zhou, S., Tian, Y., Trinh, J., Zhang, X*., and Li, X. J*. (2019) Drug screening with human SMN2 reporter identifies SMN proteinstabilizers to correct SMA pathology. Life Sci Alliance 2. https://www.ncbi.nlm.nih.gov/pubmed/30910806.
11. Chen, Z#., Ren, X#., Xu, X., Zhang, X., Hui, Y., Liu, Z., Shi, L., Fang, Y., Ma, L., Liu, Y.,Terheyden-Keighley, D., Liu, L*., and Zhang, X*. (2018) GeneticEngineering of Human Embryonic Stem Cells for Precise Cell Fate Tracing duringHuman Lineage Development. Stem Cell Reports 11, 1257-1271. https://www.ncbi.nlm.nih.gov/pubmed/30449321.
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