同济大学
导师风采
王祎龙
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个人信息

Personal Information

  • 研究员
  • 导师类别:硕士,博士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

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Contact Information

  • 所属院系:医学院
  • 所属专业: 临床医学  、 生物医学工程
  • 邮箱 : yilongwang@tongji.edu.cn
  • 工作电话 : 021-13816761031

个人简介

Personal Profile

作为同济大学医学院“生物材料与诊疗技术”课题组PI,坚持以多层有序功能磁性纳米材料与生物界面行为研究为体,以原创性生物材料与纳米医学基础研究和疾病诊疗技术方法临床转化应用为两翼,坚持立德树人、教学相长;持续培养“对社会有用、对家庭有责、对自己有爱”的学科交叉类专业技术及产业人才。


  • 研究方向Research Directions
生物材料与诊疗技术,磁性材料纳米医学,纳米-生物界面互作,体外细胞命运调控
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
科研项目

[1] 国家自然科学基金面上项目“纳米酶携载乙酯利血平抑制乳酸外排协同增效肿瘤催化治疗与免疫微环境重塑”(32271439);项目起止年月:2023年01月至2026年12月;(主持,在研)

[2] 国家自然科学基金面上项目“颗粒-蛋白相互作用分子机制及代谢重编程敏感的循环肿瘤细胞捕获方法研究”(32071395);项目起止年月:2021年01月至 2024年 12月;(主持,已结题)

[3] 国家自然科学基金面上项目“基于人源性组织异种移植瘤(PDTX)模型的新型miRNA纳米载体构建及其治疗效应研究”(31571018);项目起止时间:2016年01月至2019年12月; (主持,已结题)

[4] 上海市科委“科技创新行动计划”生物医药领域科技支撑项目“前列腺癌血清标记物free PSA/total PSA联合检测的磁性免疫层析试剂盒样品的试制”(15441905900);项目起止时间:2015年07月至2019年09月; (主持,已结题)

[5] 上海市自然科学基金项目“miRNA-介孔Fe3O4纳米晶簇新型复合系统的构建及其对头颈鳞癌细胞生长抑制效应的研究”(15ZR1443200);项目起止时间:2015年01月至2017年12月;(主持,已结题)

[6] 上海市科委引导项目“结核杆菌纳米探针检测新方法研究”(124119a1500);项目起止时间:2012年10月至2015年09月;共同主持; (联合主持,已结题)

[7] 国家自然科学基金青年基金项目“含双功能基团无机/有机非对称纳米磁性复合材料的可控制备”(51003077);项目起止时间:2011年01月至2013年12月;(主持,已结题)

[8] 中央高校基本科研项目“石墨烯/磁性复合纳米材料合成及水处理应用研究”;项目起止时间:2012年01月至2013年12月;(主持,已结题)

[9] 污染控制与资源化研究国家重点实验开放课题“石墨烯-磁性纳米材料的制备及其对典型重金属的去除研究”(PCRRF11003);项目起止时间:2011年09月至2012年12月;(主持,已结题)

[10] 同济大学青年优秀教师项目“非对称形貌及表面功能化的无机/聚合物磁性复合微球的可控制备”(2009KJ074);项目起止时间:2010年09月至2013年12月;(主持,已结题)

作为骨干成员曾经参与国家自然科学基金项目和上海市“纳米专项”项目多项。


研究成果

Chenlong He#, Huawei Liu#, Ming Yin, Jing Chen, Wensi Huang, Han Zhou, Shengming Wu and Yilong Wang*, A UOx@HMnO2 biozyme–nanozyme drivenelectrochemical platform for specific uric acidbioassays, Analyst, 2025, 150, 1377. (#Co-first author)

Hongyi Zhang, Shan Hua, Chenlong He, Ming Yin, Jingwen Qin, Huawei Liu, Han Zhou,Shengming Wu, Xingge Yu,* Hua Jiang,* Yilong Wang,* and Yuxin Qian*, Application of 4D-Printed Magnetoresponsive FOGSHydrogel Scaffolds in Auricular Cartilage Regeneration, Adv. Healthcare Mater., 2025, 2404488.  (* Co-Corresponding author )

Chenlong He, Ming Yin, Han Zhou, Jingwen Qin, Shengming Wu, Huawei Liu, Xiaoyu Yu, Jing Chen,Hongyi Zhang, Lin Zhang, and Yilong Wang*, Magnetic Nanoactuator-Protein Fiber CoatedHydrogel Dressing for Well-Balanced SkinWound Healing and Tissue Regeneration, ACS Nano, 2025, 19, 1713.

Qi Zhang*,#, Hongda Li#, Tao Zhuang#, Lehua Xu#, Wenrun Wu#, Jingjiang Pi#, Pengxiong Zhu, Liang Geng, Yunhao Duan, Jianfei Xu, Jinnan Yue, Xiuxiang Liu, Chenlong He, Xiaoli Chen, Chengchao Ruan, Shougang Zhuang, Zhongmin Liu, Yilong Wang, Lin Zhang, Jie Liu*, and Yuzhen Zhang*, CCN5 suppresses injury-induced vascular restenosis by inhibiting smooth muscle cell proliferation and facilitating endothelial repair via thymosin β4 and Cd9 pathway, European Heart Journal, 2024, 00, 1. (#Co-first author, * Co-Corresponding author)

Lehua Xu#, Chenlong He#, Shusheng Yang#, Yunxia Zhu, Peng Wang, Shengming Wu, Fangfang Guo, Yilong Wang*, Phase-transited lysozyme nanofilm with coimmobilized copper ion and heparin as cardiovascular stent multifunctional coating, Colloids and Surfaces B: Biointerfaces, 2023, 230, 113530. (#Co-first author)

Shengming Wu, Lehua Xu, Chenlong He, Peng Wang, Jingwen Qin, Fangfang Guo, Yilong Wang*, Lactate effluxinhibition bysyrosingopine/LOD co-loaded nanozyme for synergetic self-replenishing catalytic cancer therapy and immune microenvironment remodeling, Advanced Science, 2023, 2300686.

Meng Li, Shengming Wu, Chengle Zhuang, Chenzhang Shi, Lei Gu, Peng Wang, Fangfang Guo, Yilong Wang*, Zhongchen Liu*, "Metabolomic Analysis of Circulating Tumor Cells Derived Liver Metastasis of Colorectal Cancer", HELIYON, 2023, 9, e12515.

Yawen Ma#, Huimin Lin#, Peng Wang#, Haocheng Yang, Jie Yu, Hao Tian, Tianyu Li, Shengfang Ge, Yilong Wang*, Renbing Jia*, Kam W. Leong, Jing Ruan*, A miRNA-based gene therapy nanodrug synergistically enhances pro-inflammatory antitumor immunity against melanoma, ACTA Biomaterialia, 2023, 155, 538–553.(#Co-first author)

Zicheng Deng, Shengming Wu, Yilong Wang*, Donglu Shi*, Circulating Tumor Cell Isolation for Cancer Diagnosis and Prognosis, EBioMedicine, 2022, 83, 104237. (invited review article, * Co-Corresponding author )

Yanbai Pei, Shengming Wu, Peng Wang, Jingwen Qin, Lehua Xu, Yilong Wang*, "Path-Dependent Anisotropic Colloidal Assembly of Magnetic Nanocomposite-Protein Complexes", Langmuir, 2022, 38, 20, 6265–6272.

Peng Wang#, Junli Xue#, Shengming Wu, Yanbai Pei, Lehua Xu, Yilong Wang*, "Cell-Friendly Isolation and pH Sensitive Controllable Release of Circulating TumorCells by Fe3O4@CaCO3 Nanoplatform", Advanced Materials Interfaces, 2021, 2101191. (#Co-first author)

Shengming Wu, Peng Wang, Jingwen Qin, Yanbai Pei, Yilong Wang*,"GSH-Depleted Nanozymes with Dual-Radicals Enzyme Activities for Tumor Synergic Therapy" , Advanced Functional Materials, 2021, 2102160.

Shengming Wu#, Lei Gu#, Jingwen Qin, Lei Zhang, Yishu He, Jian Zhao, Fenyong Sun*, Zhongchen Liu*, Yilong Wang*, Rapid Label-free Isolation of Circulating Tumor Cells from Patients Peripheral Blood using Positively-charged Fe3O4 Nanoparticles,ACS Appl. Mater. Interfaces, 2020, 12, 4193-4203. (#Co-first author, * Co-Corresponding author)

Yishu He, Jingwen Qin, Shengming Wu, Haocheng Yang, Huiyun Wen*, Yilong Wang*, Cancer Cell-Nanomaterial Interface: Role of Geometry and Surface Charge of Nanocomposites on the Capture Efficiency and Cell Viability, Biomaterials Science,2019,DOI: 10.1039/c9bm00037b

Yilong Wang#,*, Xiao Han#, Zheng Cui*, Donglu Shi*, Bioelectricity, Its Fundamentals, Characterization Methodology, and Applications in Nano-Bioprobing and Cancer Diagnosis, Advanced Biosystems, 2019, 1900101, DOI: 10.1002/adbi.201900101. (review article, # Co-first author, * Co-Corresponding author )

Wei Tian, Fan Li, Shengming Wu, Gen Li, Lieying Fan, Xue Qu*, Xinming Jia*, Yilong Wang*, Efficient Capture and T2 Magnetic Resonance Assay of Candida albicans with Inorganic Nanoparticles: Role of Nanoparticle Surface Charge and Fungal Cell Wall, ACS Biomaterials Science & Engineering, 2019, DOI:10.1021/acsbiomaterials.9b00069. (* Co-Corresponding author )

Yilong Wang#; Shuyang Sun#; Zhiyuan Zhang, Donglu Shi, Nanomaterials for Cancer Precision Medicine, Advanced Materials, 2018, 30,(17): 1705660. DOI: 10.1002/adma.201705660 (# Co-first author, review article)

Chang Xu, Qishuai Feng, Haocheng Yang, Guangxue Wang, Liqun Huang, Qianwen Bai,Chuyi Zhang, Yilong Wang*, Yingna Chen, Qian Cheng, Yu Han, Zuoren Yu*, Maciej S. Lesniak, Yu Cheng*, A Light-Triggered Mesenchymal Stem Cell Delivery System for Photoacoustic Imaging and Chemo-Photothermal Therapy of Triple Negative Breast Cancer, Advanced Science, 2018, 5, 1800382. (* Co-Corresponding author )

Jian Zhao#,*, Shengming Wu#, Jingwen Qin, Donglu Shi*, and Yilong Wang*, Electrical-Charge-Mediated Cancer Cell Targeting via Protein Corona-Decorated Superparamagnetic Nanoparticles in a Simulated Physiological Environment, ACS Appl. Mater. Interfaces, 2018, 10, 41986-41998. (# Co-first author, * Co-Corresponding author )

Xiao Han; Zicheng Deng; Zi Yang; Huanhuan Zhu; Bingdi Chen; Yilong Wang*; Zheng Cui; Rodney C. Ewing; Donglu Shi*, Biomarkerless targeting and photothermal cancer cell killing by surface-electrically-charged superparamagnetic Fe3O4 composite nanoparticles,  Nanoscale,2017, 9, 1457~1465. (Back cover article, * Co-Corresponding author )

Shuyang Sun#; Yilong Wang#; Rong Zhou; Zicheng Deng; Yong Han; Xiao Han; Wenjie Tao; Zi Yang; Chaoji Shi; Duo Hong; Jiang Li; Donglu Shi*; Zhiyuan Zhang*, Targeting and Regulating of an Oncogene via Nanovector Delivery of MicroRNA using Patient-Derived Xenografts, Theranostics, 2017, 7, 677~693. (# Co-first author, * Co-Corresponding author,Front cover article)

Du, Juan; Zhao, Yong; Yang, Zi; Xu, Changhua; Lu, Ying*; Pan, Yingjie; Shi, Donglu; Wang, Yilong*, Influence of controlled surface functionalization of magnetic nanocomposites on the detection performance of immunochromatographic test, Sensors and Actuators B: Chemical, 2016, 237, 817~825. (* Co-Corresponding author )

Han, Xiao; Huang, Shiming; Wang, Yilong*; Shi, Donglu*, Design and development of anisotropic inorganic/polystyrene nanocomposites by surface modification of zinc oxide nanoparticles, Materials Science and Engineering: C, 2016, 64, 87~92. (* Co-Corresponding author )

Bingdi Chen#, Wenjun Le#, Yilong Wang, Zhuoquan Li, Dong Wang, Lei Ren, Ling Lin, Shaobin Cui,Jennifer J. Hu, Yihui Hu, Pengyuan Yang, Rodney C. Ewing, Donglu Shi* ,Zheng Cui*, Targeting Negative Surface Charges of Cancer Cells by Multifunctional Nanoprobes, Theranostics, 2016, 6(11): 1887-1898. (#Co-first author, * Co-Corresponding author )

Tian Li, Xiao Han, Yilong Wang*, Feng Wang, Donglu Shi, Preparation of Spherical Caged Superparamagnetic Nanocomposites with Completed Inorganic Shell via a Modified Miniemulsion Technology, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2015, 477, 84-89.

Hua Yang, Hui Ma, Yilong Wang*, Bingbo Zhang, Lianhua Qin, Zhonghua Liu, Junmei Lu, Xiaochen Huang, Jie Wang, Donglu Shi, Zhongyi Hu*,Detection of Mycobacterium Tuberculosis based on H37Rv binding peptides using surface functionalized magnetic microspheres coupled with quantum dots, International Journal of nanomedicine, e, 2015,10:77-88. (* Co-Corresponding author )

Jun Yan, Yingying Liu, Yilong Wang,* Xiaowei Xu, Ying Lu,* Yingjie Pan,Fangfang Guo, Donglu Shi, Effect of Physiochemical Property of Fe3O4 Particle on Magnetic Lateral Flow Immunochromatographic Assay, Sensors & Actuators: B. Chemical, 2014, 197, 129-136. (* Co-Corresponding author )

Feng Wang, Giovanni M. Pauletti, Juntao Wang, Jiaming Zhang, Rodney C. Ewing, Yilong Wang* and Donglu Shi*, Dual Surface-functionalized Janus Nanocomposites of Polystyrene/Fe3O4@SiO2 for Simultaneous Tumor Cell Targeting and Stimulus-induced Drug Release, Advanced Materials, 2013, 25, 3485–3489. (* Co-Corresponding author )

Tian Li,Yilong Wang*,Fangfang Guo,Donglu Shi,Synthesis and Biomedical Applications of Magnetic Nanocomposites with Complex Morphologies, Progress In Chemistry, In press, 2013.

Yulin Tang, Hongguang Guo, Lan Xiao, Naiyun Gao, Shuili Yu, Yilong Wang*, Adsorption behavior and mechanisms of fluoroquinolone antibiotics on the reduced graphene oxide/magnetite composites, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2013, 424, 74– 80.

Yilong Wang, Song Liang, Bingdi Chen, Fangfang Guo, Shuili Yu, Yulin Tang*, Synergistic removal of Pb(II), Cd(II) and humic acid by Fe3O4@mesoporous silica-graphene oxide composites, PLoS One, 2013, 8, e65634:1-8.

Yulin Tang*, Song Liang, Juntao Wang, Shuili Yu, Yilong Wang*, Amino functionalized core-shell magnetic mesoporous composite microspheres for Pb(II) and Cd(II) removal, Journal of Environmental Sciences, 2013, 25, 830-837. (* Co-Corresponding author )

Fangyingkai Wang, Yulin Tang, Bingbo Zhang, Bingdi Chen, Yilong Wang*, Preparation of Novel Magnetic Hollow Mesoporous Silica Microspheres and their Efficient Adsorption, Journal of Colloid & Interface Science 2012, 386, 129-134.

Yulin Tang*, Song Liang, Shuili Yu, Naiyun Gao, Jun Zhang, Haicheng Guo, Yilong Wang*, Enhanced adsorption of humic acid on amine functionalized magnetic mesoporous composite microspheres, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2012, 406, 61- 67. (* Co-Corresponding author )

Yilong Wang*, Fangyingkai Wang, Bingdi Chen, Hong Xu*, Donglu Shi. “Facile one-pot synthesis of yolk–shell superparamagnetic nanocomposites via ternary phase separations” Chemical Communications, 2011, 47, 10350 - 10352. (* Co-Corresponding author )

Yilong Wang*, Hong Xu, Yongsheng Ma, Fangfang Guo, Feng Wang, and Donglu Shi*. “Facile One-Pot Synthesis and Morphological Control of Asymmetric Superparamagnetic Composite Nanoparticles” Langmuir, 2011, 27, pp 7207–7212. (* Co-Corresponding author )

Yilong Wang, Hong Xu, Weili Qiang, Hongchen Gu, and Donglu Shi, “Asymmetric Composite Nanoparticles with Anisotropic Surface Functionalities”,Journal of Nanomaterials, 2009, 620269, 1-5

Yilong Wang, Hong Xu, and Hongchen Gu*, Synthesis of Raspberry-Like SiO2/Polystyrene Nanocomposite Particles via Miniemulsion Polymerization, Journal of Nanoscience and Nanotechnology, 2009, 9, 1571-1576.

Yilong Wang, Pedro H. C. Camargo, Sara E. Skrabalak, Hongchen Gu, and Younan Xia*, “A Facile, Water-Based Synthesis of Highly Branched Nanostructures of Silver”,Langmuir, 2008, 24, 12042-12046.

Weili Qiang#, Yilong Wang#, Ping He, Hong Xu*, Hongchen Gu, and Donglu Shi, “Synthesis of Asymmetric Inorganic/Polymer Nanocomposite Particles via Localized Substrate Surface Modification and Miniemulsion Polymerization”, Langmuir, 2008, 24, 606-608. (#co-first author, * Co-Corresponding author)

已授权中国发明专利

[1] 一种磁性荧光双功能氧化硅空心微球的制备方法,王祎龙;马方;陈炳地;张兵波;郭方方;时东陆;专利号:ZL 2011 1 0132719.7;

[2] 具有核壳结构及表面各向异性双功能团的磁性二氧化硅微球及其制备方法,王祎龙;张兵波;郭方方;时东陆;专利号:ZL 2011 1 0029024.6;

[3] 一种壳层中包埋磁性纳米颗粒的介孔氧化硅空心微球的制备方法,王祎龙;唐玉霖;王方英凯;专利号:ZL 201110344263.0;

[4] 具有非对称结构及表面各向异性双功能基团的磁性氧化硅聚合物复合微球的制备方法,王祎龙;时东陆;专利号:ZL 201310182495.X;

[5] 一种蛋黄-蛋壳结构的氧化锌三元复合纳米材料及其制备方法,王祎龙,韩筱,时东陆,申请号:201410253569.9,申请日期:2014.6.10,授权公告日:2016.4.20,专利号:ZL 201410253569.9

[6] 一种由两种高分子共修饰的生物相容性磁性微球及其制备方法,王祎龙,李恬,韩筱,时东陆,申请号:201410305539.8,申请日期:2014.7.1,授权公告日:2016.6.15,专利号:ZL 201410305539.8

[7] 一种磁性纳米复合材料的制备方法、由该方法制备的产品及其应用,唐玉霖;王祎龙;于水利; 专利号:ZL 2011 1 0407318.8;

[8] 一种高性能锂离子电池负极材料石墨烯负载纳米氧化亚钴的制备方法,陈炳地;郭方方;王祎龙;张兵波;时东陆;专利号:ZL 2011 1 0443045.2;


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