课题组主页：https://www.x-mol.com/groups/shishuo

(1) 可调控免疫应答的新型奥沙利铂前药分子构建及其增敏铁死亡研究 (国家自然科学基金)

(2) 基于DNA构象变化的逻辑门网络化构筑及其分子密码应用 (国家自然科学基金)

(3) G-四链体稳定与解旋的分子构筑及肌萎缩侧索硬化症(ALS)的基因疗法初探 (国家自然科学基金)

(4) 靶向癌基因启动子区G-四链体的钌配合物的合成及抗肿瘤机制研究(国家自然科学基金)

(5) 手性钌铱双核配合物对G-quadruplex和I-motif的选择性识别研究 (国家自然科学基金)

(6) 重编程有氧呼吸的新型奥沙利铂前药递送系统的构建及其增敏铜死亡研究 (上海市自然科学基金)

(7) 新型药物制剂递释系统的设计及其多通路协同抗肿瘤研究 (同济大学自主原创重点项目)

(8) DNA生物传感器的构建与若干疾病的分子诊断研究 (中央高校基本科研业务费)

(9) 单双核钌配合物与DNA的键合性质研究 (同济大学优秀青年人才)

(10) 小分子药物设计合成及抗肿瘤活性测试研究 (横向项目)

(1) 可调控免疫应答的新型奥沙利铂前药分子构建及其增敏铁死亡研究 (国家自然科学基金)

(2) 基于DNA构象变化的逻辑门网络化构筑及其分子密码应用 (国家自然科学基金)

(3) G-四链体稳定与解旋的分子构筑及肌萎缩侧索硬化症(ALS)的基因疗法初探 (国家自然科学基金)

(4) 靶向癌基因启动子区G-四链体的钌配合物的合成及抗肿瘤机制研究(国家自然科学基金)

(5) 手性钌铱双核配合物对G-quadruplex和I-motif的选择性识别研究 (国家自然科学基金)

(6) 重编程有氧呼吸的新型奥沙利铂前药递送系统的构建及其增敏铜死亡研究 (上海市自然科学基金)

(7) 新型药物制剂递释系统的设计及其多通路协同抗肿瘤研究 (同济大学自主原创重点项目)

(8) DNA生物传感器的构建与若干疾病的分子诊断研究 (中央高校基本科研业务费)

(9) 单双核钌配合物与DNA的键合性质研究 (同济大学优秀青年人才)

(10) 小分子药物设计合成及抗肿瘤活性测试研究 (横向项目)

90. A PROTAC-BasedCuproptosis Sensitizer in Lung Cancer Therapy, Yu Wang†, Xiaoyang Yao†,Yingying Lu, Juan Ruan, Zhao Yang, Chunhui Wang, Niantong Yang, Yan Gao,Shuo Shi*, Advanced Materials, 2025, 2501435.

89. Ion InterferenceInduced by Ca-Mn Nanoplatform Enhances Ferroptosis and Promotes Immune Responsefor Osteosarcoma Treatment, Minyi Zhang†, Qi Wang†, Chen Li, MengyaoChen, Chunhui Wang, Zikang Wang, Tao Xia, Chengqing Yi*, Shuo Shi*, Journalof Advanced Research, 2025, 10.1016/j.jare.2025.06.022.

88. Pyroptosis-InducingPlatinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and MetastasisInhibition in Triple-Negative Breast Cancer, Xinda Yang†, Chuansheng Xu†, Youliang Zeng,Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, ZongwanMao*, Shuo Shi*, Advanced Science, 2025, e05567.

87. Engineered Microneedle System Enables the SmartRegulation of Nanodynamic Sterilization and Tissue Regeneration for WoundManagement. Shiyang Lin†, Zhongqi Cui†, Qingqiong Luo†, Chen Li, Yue Zhang,Fengjiao Yang, Yichuan Chen, Chuansheng Xu, Yan Gao, Shasha Zhao, Fenyong Sun,Dandan Shen,* Qi Wu,* and Shuo Shi*, Advanced Science, 2025, 12, 202412226.

86. A locally-adaptednanoreactor for autophagy inhibition-enhanced cascade starvation-chemodynamictherapy, Chunhui Wang†, Ruihao Li†, Chunyan Dong* andShuo Shi*, Journal of Colloid and Interface Science, 2025, 695,137820.

85. A New Oxaliplatin(IV) Prodrug Inducing FerroptosisThrough a Triple-Pathway Mechanism and Activating Anti-Cancer Immunity XindaYang†, Nan Huang†, Mingyang Li, Xiaoli Zhu,Chunhui Wang, Yue Zhang, Chuansheng Xu, Niantong Yang, Sirui Chen, Yuheng Pan,Bing Shen*, Shuo Shi*, Science China Chemistry, 2025, 68, 4297–4310.

84. Spontaneous Hydrogen-Releasing Nanoenzyme AlleviatesOsteoarthritis via Oxidative Stress Reduction and Mitochondrial DysfunctionReversal, Qi Wang†, Minyi Zhang†, Weihag Jiang, Deiian Li, Beijie Qi, Shi, Shi,Shuo Shi*, Chengqing Yi*, Journal of Nanobiotechnology, 2025, 23,662.

83. SRIB-Loaded Nanoplatform Disrupts Cellular Homeostasisby Depleting Glutathione and Inhibiting Stress Granules Formation to DriveImmunosuppressive Reprogramming, Yu Wang†, Zhongqi Cui†, Yang Wang†, ChunhuiWang, Yue Zhang, Nan Huang, Xinda Yang, Fenyong Sun, Sufeng Qiang*, Shuo Shi*,Bing Shen*, Chemical Engineering Journal, 2025, 523, 168568

82. Antibody-drug conjugates (ADCs): “smart missiles”targeting cancer therapy, Xiaoyang Yao†, Yingying Lu†, Shuo Shi*, Yu Wang*, Colloidsand Surfaces B: Biointerfaces, 2026, 257, 115161.

81. Reducing the Availability ofEndogenous Copper and Glucose for Cascade Starvation Therapy and ChemodynamicTherapy. Chunhui Wang†, Pingting Ye†, Mengyao Chen, Ruihao Li, Yixuan Wen, YuWang, Xiaohan Tong, Chunyan Dong* and Shuo Shi*, Materials Today Bio, 2025, 32,101702.

80. A Positive-Feedback LoopSuppresses TNBC Tumour Growth by Remodeling Tumour Immune Microenvironment andInducing Ferroptosis, Pingting Ye†, Chunhui Wang†, Yixuan Wen, Kang Fang, QiLi, Xin Zhang, Jingxian Yang, Ruihao Li, Mengyao Chen, Xiaohan Tong, Shuo Shi*,Chunyan Dong*, Biomaterials, 2025, 315, 122960.                                                                       

79. Dual Inhibition of DNA DamageRepair Sensitizes Photodynamic Therapy for Triple Negative Breast Cancer.Yanting Sun†, Mengyao Chen†, Pingting Ye†, Jingxian Yang, Kang Fang, ChunhuiWang, Ruihao Li, Ting Fan, Shuo Shi*, Chunyan Dong*, Materials Today Bio, 2025,32, 101706.

78. Advanced Logic Computing andHybrid Crypto-Steganography for Molecular Information Coding Using Gold/SilverNanoclusters. Mohamed Nabeel Mattath, Sumon Pratihar, Thimmaiah Govindaraju,*and Shuo Shi*, ACS Applied Materials Interface, 2025, 17, 18731−18740.

77.  NIR-activated hydrogel with dual-enhanced antibiotic effectivenessfor thorough elimination of antibiotic-resistant bacteria, Fengjiao Yang†, Yuqi Ge1†, Yue Zhang†, Zhongqi Cui, Shiyang Lin, Wenxuan Ni, Zijiu Sun, Dandan Shen, Jichao Zhu, Li Liu, Shasha Zhao, Nan Huang, Fenyong Sun, Yingying Lu*, Shuo Shi*, Jinghua Li*, ACS AppliedMaterials Interface, 2025, 17, 2952−2965.

76. A Responsive CocktailNano-strategy Breaking the Immune Excluded State Enhances Immunotherapy ofTriple Negative Breast Cancer, Jingxian Yang†, Mengyao Chen†, Ruihao Li, Yanting Sun,Pingting Ye, Kang Fang, Chunhui Wang, Shuo Shi*,and Chunyan Dong*,  Nanoscale, 2025,17, 4610–4623.

75. Mengyao Chen#, Chang Xu#,Chunhui Wang, Nan Huang, Zhixuan Bian, Yixuan Xiao, Juan Ruan, Fenyong Sun*,Shuo Shi*, Three birds with one stone: Copper ions assisted synergisticcuproptosis/chemodynamic/photothermal therapy by a three-pronged approach, AdvancedHealthcare Materials, 2024, 13, 2401567.

74. Mengyao Chen#, Xiaohan Tong#,Yanting, Sun, Chunyan Dong, Chen Li, Chunhui Wang, Minyi Zhang, Yixuan Wen,Pinting Ye, Ruihao Li, Jie Wan, Shujing Liang*, Shuo Shi*, A ferroptosisamplifier based on triple-enhanced lipid peroxides accumulation strategy foreffective pancreatic cancer therapy, Biomaterials, 2024, 309, 122574.

73. Xiaochun Hu†, Ruihao Li†, JieLiu, Kang Fang, Chunyan Dong*, Shuo Shi*, Engineering dual-responsiveprodrug-MOFs as immunogenic cell death initiator for enhancing cancerimmunotherapy, Advanced Healthcare Materials, 2024, 2302333.

72. Ruihao Li†, Xiaochun Hu†, WenhuiLi, Wenjing Wu, Jin Xu, Yun Lin*, Shuo Shi* and Chunyan Dong*, NebulizedpH-Responsive Nanospray Combined with Pentoxifylline and Edaravone to Lungs forEfficient Treatments of Acute Respiratory Distress Syndrome, ACS Appl. Mater.Interfaces, 2024, 16, 7, 8310–8320.

71. Kang Fang‡, Yanting Sun‡, Jingxian Yang, Xiaochun Hu,Mengyao Chen, Ruihao Li, Xinda Yang, Ting Fan, Junjie Wu, Xiaohan Tong, ChunyanDong * and Shuo Shi *, A Dual Stimuli-responsive Nanoplatform Loaded PtIV-triptolideProdrug for Achieving Synergistic Therapy Toward Breast Cancer, AdvancedHealthcare Materials, 2023, 2301328.

70. ChunhuiWang, Xinda Yang, Chunyan Dong, Keke Chai,Juan Ruan and Shuo Shi*, Cu-relatedagents for cancer therapies, Coordination Chemistry Reviews, 2023, 487, 215156.

69. YimingRao‡, Ting Fan‡, Lulu Zhou, Kang Fang,Yanting Sun, Xiaochun Hu, Anqi Wang,Ruihao Li, Zhounan Zhu, Chunyan Dong*, ShuoShi*, A positive self-sufficient H2O2and acidity enhancement circulation for boostingchemodynamic-photothermal-starvation synergistic therapy, Journal of ControlledRelease, 2023, 354, 701-712.

68. AnqiWang‡,Xinda Yang‡,Ruihao Li‡,Lujing Shao, Wenrong Zhao, Xiaochun Hu, Kang Fang, Keke Chai, Shuo Shi*,Chunyan Dong*, Immunomodulator Mediated Suppressive Tumor ImmuneMicroenvironment Remodeling Nanoplatform for Enhanced Immuno/Chemo/PhotothermalCombination Therapy of Triple Negative Breast Cancer, ACS Appl. Mater.Interfaces, 2023,15, 46, 53318–53332.

67. MohamedNabeelMattath, Debasis Ghosh, Chunyan Dong, Thimmaiah Govindaraju*, andShuo Shi*, Mercury mediated DNA-Au/Ag nanoclusters ensemble to generategray code encoder for biocomputing, Materials Horizons, 2022, 9,2109-2114. Outside Front Cover

66. XiaochunHu†, Ruihao Li†,Wenjing Wu, Kang Fang, Zhounan Zhu, Yixuan Wang, Lulu Zhou,Mengyao, Chen, Chunyan Dong*, and Shuo Shi*, AFe(III)-porphyrin-oxaliplatin(IV)nanoplatform for enhanced ferroptosis andcombined therapy, Journal of ControlledRelease, 2022, 348,660–671. 

65. MengyaoChen†, Jingxian Yang†, Chunyan Dong* and Shuo Shi*, A dual-responsive andROS-augmented nanoplatform for chemo/photodynamic/chemodynamic combinationtherapy of triple negative breast cancer, ACS Appl. Mater.Interfaces 2022, 14, 1, 57–68.

64. MengyaoChen, ChunyanDong* and Shuo Shi*, An overview of recent advancementonmanganese-based nanostructures and their application for ROS-mediatedtumortherapy, Acs Materials Letters, 2022, 4, 2415-2433.

63. RuihaoLi†, Xiaochun Hu†,Fangjian Shang, Wenjing Wu, Haijun Zhang, Yixuan Wang, JiaweiPan, Shuo Shi* andChunyan Dong*, Treatment of triple negative breastcancer by near infraredlight triggered mild temperature photothermal therapycombined withoxygen-independent cytotoxic free radicals, Acta Biomaterialia,2022,218–229. 

62. XiaochunHu†, Hui Li†, Ruihao Li, Sufeng Qiang,Mengyao Chen, Shuo Shi* and ChunyanDong*, A phase-change mediated intelligentnanoplatform forchemo/photothermal/photodynamic therapy of cancer, AdvancedHealthcareMaterials, 2022, 2202245.

61. YantingSun†, KangFang†, Xiaochun Hu, Jingxian Yang, Zhengyang Jiang, LeiFeng, Ruihao Li,Yiming Rao, Shuo Shi* and Chunyan Dong*,NIR-light-controlled G-quadruplexhydrogelfor synergistically enhancing photodynamic therapy viasustaineddelivery of metformin and catalase-like activity inbreastcancer, Materials Today Bio, 2022, 16100375.

60. LeiFeng†, Mengyao Chen†,Ruihao Li, Lulu Zhou, Chunhui Wang, Pingting Ye, XiaochunHu, Jingxian Yang, YantingSun, Zhounan Zhu, Keke Chai, Kang Fang, Shuo Shi* andChunyan Dong*, Biodegradableoxygen-producing manganese-chelated metal organicframeworks for tumor-targetedsynergistic chemo/photothermal/ photodynamictherapy, Acta Biomaterialia, 2022, 138, 463–477.

59. SufengQiang†, Xiaochun Hu†,Ruihao Li, Wenjing Wu, Kang Fang, Hui Li, Yanting Sun,Shujing Liang, WenrongZhao, Mengjie Wang, Yun Lin, Shuo Shi*, and ChunyanDong*, CuS nanoparticles-loadedand cisplatin prodrug conjugatedFe(III)-MOFs forMRI-guided combination of chemotherapyandNIR-II photothermal, ACS Appl. Mater.Interfaces, 2022, 14,32, 36503–36514.

58. PintingYe, Lei Feng, Shuo Shi*, Chunyan Dong*, Themechanismsof lncRNA-mediated multidrug resistance and the clinical applicationprospectsof lncRNAs in breast cancer, Cancers, 2022, 14(9), 2101.

57. JieLiu†, Xiaochun Hu†, LeiFeng, Yun Lin, Shujing Liang, Zhounan Zhu, Shuo Shi* andChunyan Dong*, Carbonicanhydrase IX‑targeted H‑APBC nanosystem combined withphototherapy facilitatesthe efficacy of PI3K/mTOR inhibitor and resists HIF‑1α‑dependenttumor hypoxia adaptation, Journal of Nanobiotechnology, 2022, 20, 187.

56. LuluZhou#, JinjinChen#, Ruihao Li, Lizhen Wei, Haitao Xiong, Chunhui Wang, KekeChai,Mengyao Chen, Zhounan Zhu, Tianming Yao, Yun Lin, Chunyan Dong* andShuoShi*, Metal-polyphenol-network coated prussian blue nanoparticlesforsynergistic ferropotosis and apoptosis via triggered GPX4 inhibitionandconcurrent in situ bleomycin toxification, Small, 2021, 17, 2103919.

55. LuluZhou#, Jinjin Chen#, YunhaoSun, Keke Chai, Zhounan Zhu, ChunhuiWang,  Mengyao Chen, Wenmei Han,Xiaochun Hu, RuihaoLi,  Tianming Yao, Hui Li, Chunyan Dong* andShuo Shi*, Aself-amplifiednanocatalytic system for achieving "1+1+1>3"chemodynamic therapyon triple negative breast cancer, Journal ofNanobiotechnology, 2021, 19, 261.

54. MengyaoChen, ChunyanDong* and Shuo Shi*, Nanoparticle-mediated siRNA deliveryandmultifunctional modification strategies for effective cancer therapy,AdvancedMaterials Technology, 2021, 202001236.

53. XiaochunHu#,Yonglin Lu# , Wenrong Zhao, MenglinSun, Ruihao Li, LeiFeng, Tianming Yao, Chunyan Dong*, ShuoShi*, A PDA-DTC/Cu-MnO2 nanoplatformfor MR imaging andmulti-therapy of triple-negative breast cancer, Chem. Comm, 2021, 57,4158-4161.

52. WenrongZhao#,Xiaochun Hu#, Wenhui Li, Ruihao Li,Jinjin Chen, Lulu Zhou, Sufeng Qiang,Shuo Shi*, and ChunyanDong*, M2-like TAMs functionreversal contributes tobreast cancer eradication by combination dual immunecheckpoint blockade andphotothermal Therapy, Small, 2021, 17, 2007051.

51.YantingSun†,Yuling Li†, Shuo Shi*, and Chunyan Dong*, Exploiting a newapproach to destroythe barrier of tumor microenvironment: nano-architecturedelivery systems,Molecules 2021, 26(9), 2703.

50. JinjinChen#, Lulu Zhou#,Chunhui Wang, Yunhao Sun, Yonglin Lu, Ruihao Li, Xiaochun Hu,Mengyao Chen, LvChen, Tianming Yao, Shuo Shi,* and Chunyan Dong*,MultifunctionalSN38-conjugated nanosystem for defeating myelosuppression anddiarrhea inducedby irinotecan on esophageal cancer, Nanoscale, 2020, 12,21234-21247. 

49. JouharshaAfthab, Nafeesa Khatoon,Lulu Zhou, Tianming Yao, and Shuo Shi*, HepatoprotectiveAngelica sinensis silver nanoformulation against multidrugresistant bacteriaand the integration of multicomponent logic gate system, Nanoscale, 2020, 12,19149–19158.

48. ChunhuiWang, Jingxian Yang,Chunyan Dong* and Shuo Shi*, Glucose oxidase related cancertherapies, Adv. Therap., 2020, 2000110.

47. XiaochunHu,#Yonglin Lu,# Lulu Zhou, Lv Chen, Tianming Yao, Liang Shujing, ChunyanDong,* ShuoShi*, Post syntheses strategy to integrate porphyrinicmetal-organicframeworks with CuS NPs for synergistic enhanced phototherapy, J.Mater. Chem.B, 2020, 8, 935-944.

46. XiaochunHu, Yonglin Lu,Chunyan Dong, Xuewen Wu, Lulu Zhou, Lv Chen, Tianming Yao*, ShuoShi*, A Ru(II) polypyridyl alkynecomplex based metal−organic frameworks forcombinedphotodynamic/photothermal/chemotherapy, Chem. Eur. J. 2020, 26, 1668 –1675.

45. LuluZhou#, Lv Chen#, Xiaochun Hu, Yonglin Lu, Wenjie Liu, Tianming Yao,ChunyanDong, *and Shuo Shi*, A Cu9S5 nanoparticle-based CpG delivery system forsynergistic photothermal-, photodynamic- and immunotherapy, CommunicationsBiology, 2020, 3, 343.

44. RuihaoLi#, Yabin Ma#,Xiaochun Hu, Wenjing Wu, Xuewen Wu, Chunyan Dong, Shuo Shi*,YunLin*, [Ru(phen)2podppz]2+ significantly inhibitsglioblastoma growth in vitro and vivo with fewer side-effects compared withcisplatin, Dalton Trans., 2020, 49, 8864 –8871.

43. JingxianYang, Chunhui Wang, Shuo Shi*, Chunyan Dong*, Nanotechnologies for enhancingcancer immunotherapy, Nano Research, 2020, 13(10): 2595–2616.

42. WenjieLiu, Xiaochun Hu, LuluZhou, Ying Tu, Shuo Shi*, Tian-Ming Yao*, Anorientation-inspired perspective on molecular inhibitor of tau aggregation bycurcumin conjugated with Ru(II) complex scaffold, J. Phys. Chem. B,2020, 124,2343−2353.

41. LvChen#,Lulu Zhou#, Chunhui Wang, Yonglin Lu, Jie Liu, Xiaochun Hu, Tianming Yao, YunLin, Shujing Liang, Shuo Shi* and Chunyan Dong*, Tumor-targeted drug and CpGdelivery system for phototherapy and docetaxel-enhanced-immunotherapy withpolarization towardM1-type macrophages on triple negative breast cancer, Adv.Mater. 2019,31, 1904997.

40. XiaochunHu#,Yonglin Lu#, Xiaoke Shi, Tianming Yao, Chunyan Dong*, Shuo Shi*,Integrating in situ formation of nanozymes with mesoporous polydopamine forcombined chemo, photothermal and hypoxia-overcoming photodynamic therapy, Chem.Commun., 2019,55, 14785-14788.

39. XiaochunHu, Zhenli Xu, Jiwen Hu,Chunyan Dong, Yonglin Lu, Xuewen Wu, Maierhaba Wumaier,Tianming Yao*, ShuoShi*, A redox-activated theranostic nanoplatform: toward glutathione-responseimaging guided enhanced photodynamic therapy, Inorg. Chem. Front., 2019, 6,2865–2872,

38. MaierhabaWumaier, Tian-Ming Yao*, Xiao-Chun Hu, Zhi-An Hu and Shuo Shi*, Luminescent Ru(II)-thiolsmodified silver nanoparticles for lysosome targeted theranostics, DaltonTrans., 2019, 48, 10393–10397.

37. MaierhabaWumaier, Jing-Jing Shi*,Tian-Ming Yao*, Xiao-Chun Hu, Ru-Ru Gao, Shuo Shi*,G-quadruplex and duplex DNA binding studies of novel ruthenium(II) complexescontaining ascididemin ligands, Journal of Inorganic Biochemistry, 2019, 196,110681.

36. RuiminZang, XinWang, Yanyan Zhu, Tianming Yao, Shuo Shi*, Label-free molecular probe basedon G-quadruplex and strand displacement for sensitive and selective detectionand naked eye discrimination of Exon 2 Deletion of AIMP2, Chem. Biol. Drug.Des., 2019; 93, 993–998.

35. XiaochunHu, Danjing Yang, Tianming Yao*, Ruru Gao, Maierhaba Wumaier and ShuoShi*,Multi-factors (Tail/Loop/Link/Ions) regulation for G-quadruplexes enantio selectivityof Δ- and Λ- [Ru(bpy)2(dppz-idzo)]2+, Dalton Trans.,2018, 47, 5422–5430.

34. AoHuang, Luning Zhang, Weiwei Li, Zeyu Ma, Shuo Shi* and Tianming Yao*,Controlled fluorescence quenching by antibody-conjugated graphene oxide as amechanism for tau protein sensing, RSOS, 2018, 5, 171808.

33. Ru-RuGao, Tian-Ming Yao*, Xiao-YanLv, Yan-Yan Zhu, Yi-Wei Zhang and Shuo Shi*,Integration of G-quadruplex and DNA-templated Ag NCs for nonarithmeticinformation processing, Chemical Science, 2017,8, 4211–4222.

32. Ru-RuGao, Shuo Shi*, Yu-Jie Li, Maierhaba Wumaier, Xiao-Chun hu and Tian-Ming Yao*,Coordination polymer nanoparticles from nucleotide and lanthanide ions as aversatile platform for color-tunable luminescence and integrating boolean logicoperations, Nanoscale, 2017, 9, 9589–9597.

31. Ru-RuGao, Shuo Shi*, Ying Zhu, Hai-Liang Huang, and Tian-Ming Yao*, A RET-supportedlogic gate combinatorial library to enable modeling and implementation ofintelligent logic functions, Chemical Science, 2016, 7, 1853-1861.

30. JuanjuanLi, Xiaochun Hu, Shuo Shi*, Yiwei Zhang and Tianming Yao*, Three label-freethrombin aptasensors based on aptamers and [Ru(bpy)2(o-mopip)]2+,J. Mater. Chem. B, 2016, 4, 1361–1367.

29. HailiangHuang, ShuoShi*, Xing Gao, Ruru Gao, Ying Zhu, Xuewen Wu, Ruimin Zang, andTianmingYao*, A universal label-free fluorescent aptasensor based on Ru complexand quantum dots for adenosine, dopamine and 17 β-estradiol detection,Biosensors and Bioelectronics, 2016, 79, 198–204.

28. YingZhu, Xiao-chun Hu, ShuoShi*, Ru-ru Gao, Hai-liang Huang, Yan-yan Zhu, Xiao-yanLv, Tian-ming Yao*, Ultrasensitive and universal fluorescent aptasensor for thedetection of biomolecules (ATP, Adenosine and Thrombin)based on DNA/Agnanoclusters fluorescence light-up system, Biosensors and Bioelectronics, 2016,79, 205–212.

27. XinWang, Lihong Pei, Xiumin Fan, Shuo Shi*, [Ru(L)2(3-tppp)]2+ (L=bpy,phen) stabilizes two different forms of the human telomeric G-quadruplex DNA,Inorganic Chemistry Communications, 2016, 72, 7–12.

26. ShuoShi*, Xing Gao, Hailiang Huang, Juan Zhao, and Tianming Yao, Effect of theancillary ligands on the spectral properties and G-quadruplexes DNA bindingbehaviours: a combined experimental and theoretical study, Chem. Eur.J.2015,21,13390 –13400.

25. ShuoShi*, Jin-Hong Xu, Xing Gao, Hai-Liang Huang and Tian-Ming Yao*, Bindingbehaviours for different types of DNA G-quadruplexes: enantiomers of[Ru(bpy)2(L)]2+ (L= dppz, dppz-idzo), Chem. Eur. J.2015, 21, 11435 – 11445.

24. HailiangHuang, ShuoShi*, Xuyue Zheng, Tianming Yao*, Sensitive detection for coralyneandmercury ions based on homo-A/T DNA by exonuclease signalamplification,Biosensors and Bioelectronics, 2015, 71, 439–444.

23. XuyueZheng, Tianming Yao*, Ying Zhu and Shuo Shi*, Cu2+ Modulated silvernanoclusters as an On-Off-On fluorescence probe for the selective detection ofL-histidine, Biosensors and Bioelectronics, 2015,66, 103–108.

22. XingGao, Shuo Shi*, Jun-Liang Yao, Juan Zhao and Tian-Ming Yao*, Impacts ofterminal modification of [Ru(phen)2dppz]2+ on theluminescence properties: atheoretical study, Dalton Trans., 2015, 44,19264–19274.

21. Xiao-HuiLu, ShuoShi*, Jun-Liang Yao, Xing Gao, Hai-Liang Huang, Tian-Ming Yao*, Two structurallyanalogous ruthenium complexes as naked-eye and reversible molecular “lightswitch” for G-quadruplex DNA, Journal of Inorganic Biochemistry, 2014, 140,64-71.

20. LinlinWang, Tianming Yao*, Shuo Shi*, Yanlin Cao, Wenliang Sun A label-freefluorescent probe for Hg2+ and biothiols based on graphene oxide andRu-complex, Scientific Reports, 2014, 4, 5320.

19. YanlinCao, Shuo Shi*, Linlin Wang, Junliang Yao and Tianming Yao*, Ultrasensitivefluorescence detection of heparin based on quantum dots and a functionalruthenium polypyridyl complex, Biosensors and Bioelectronics, 2014, 55,174-179.

18. ShuoShi*‡, ShaneGao,‡ Tongcheng Cao, Jie liu, Xing Gao, Jian Hao, Chunyan Lv,Hailiang Huang, Jun Xu*, Tianming Yao*, Targeting human telomeric G-quadruplexDNA and inhibition of telomerase activity with [(dmb)2Ru(obip)Ru(dmb)2]4+,PloS ONE, 2013, 8(12), e84419.

17. ShuoShi*, Xin Wang, Wenliang Sun, Xiangyang Wang, TianmingYao*, Liangnian Ji,Label-free fluorescent DNA biosensors based on metallo intercalators andnanomaterials, Methods, 2013, 64, 305-314.

16. ShuoShi*, Hai-Liang Huang, Xing Gao, Jun-Liang Yao, Chun-YanLv, Juan Zhao,Wen-Liang Sun, Tian-Ming Yao*, Liang-Nian Ji，Acomparative study of the interaction of two structurally analogous rutheniumcomplexes with human telomeric G-quadruplex DNA, Journal of InorganicBiochemistry, 2013,121,19-27.

15. JunliangYao, Xing Gao, Wenliang Sun, Tianming Yao*, Shuo Shi*, and Liangnian Ji,Molecular hairpin: a possible model for inhibition of tau aggregation by tannicacid, Biochemistry 2013, 52, 1893−1902.

14. WenliangSun, Junliang Yao, Tianming Yao* and Shuo Shi*, Label-free fluorescent DNA sensorfor the detection of silver ions based on molecular light switch Ru complex andunmodified quantum dots, Analyst, 2013,138, 421-424.

13. Jun-LiangYao, Xing Gao, Wenliang Sun, Shuo Shi* and Tian-Ming Yao*, [Ru(bpy)2dppz-idzo]2+:Acolorimetric molecular “light switch” and powerful stabilizer for G-quadruplexDNA, Dalton Trans., 2013, 42, 5661–5672.

12. ShuoShi*, Juan Zhao, Xing Gao, Chunyan Lv, LiYang, Jian Hao, Hailiang Huang,Junliang Yao, Wenliang Sun, Tianming Yao*, and Liangnian Ji, Molecular “lightswitch” for G-quadruplexes DNA: cycling the switch on and off, Dalton Trans,2012., 41, 5789–5793.

11. ShuoShi *, Chunyan Lv, Xing Gao, Juan Zhao, Junliang Yao, Wenliang Sun, HailingHuang, Tianming Yao*, Liangnian Ji, [Ru(bpy)2(bppp)]2+binds two different forms of the humantelomeric G-quadruplex structure,Inorganic Chemistry Communications, 2012, 24,212–215.

10. YaoJunliang, Gao Xing, Sun Wenliang, Fan Xuezhong, Shi Shuo*, Yao Tianming*, Anaked-eye on–off–on molecular “light switch” based on a reversible“conformational switch” of G-quadruplex DNA, Inorg. Chem., 2012,51,12591-12593.

9. WenliangSun, Tianming Yao* and Shuo Shi*, A molecular light switch Ru complex andquantum dots for the label-free, aptamer-based detection of thrombin, Analyst,2012, 137,1550–1552.

8. ShuoShi*, Juan Zhao, Xiaoting Geng, Tianming Yao*, HailiangHuang, Tianlin Liu, LengfengZheng, Zonghui Li, DanjingYang, and Liangnian Ji, Molecular “light switch” forG-quadruplexes and i-motif of human telomeric DNA:[Ru(phen)2(dppz)]2+,Dalton Trans, 2010, 39，2490-2493.

7. ShuoShi *, Xiaoting Geng, Juan. Zhao,Tianming Yao*, Chaoran Wang, Danjing Yang,Lengfeng Zheng, Liangnian Ji, Interaction of [Ru(bpy)2(dppz)]2+withhuman telomeric DNA: preferential binding to G-quadruplexes over i-motif, Biochimie,2010, 92, 370-377.

6. ShuoShi*, Tian-ming Yao, Xiao-ting Geng, Ling-feng Jiang, Jie Liu, Qing-yuan Yang,and Liangnian Ji*, Synthesis, characterization and DNA-binding of chiralcomplexes D- and L- [Ru(bpy)2(pyip)]2+, Chirality, 2009,21, 276-283.

5. ShuoShi*, Tian Xie, Tian-Ming Yao*,Chao-Ran Wang, Xiao-Ting Geng, Dan-Jing Yang,Lin-Jie Han, Liang-Nian Ji, Synthesis, characterization, DNA-binding andDNA-photocleavage studies of [Ru(bpy)2(pmip)]2+ and[Ru(phen)2(pmip)]2+ (pmip =2-(2′-pyrimidyl)imidazo[4,5-f][1,10]phenanthroline, Polyhedron, 2009,18,1355–1361.

4. ShuoShi, Jie Liu*, Tianming Yao, Xiaoting Geng, Lingfeng Jiang, Qingyuan Yang, LinCheng, and Liangnian Ji*, Promoting the formation and stabilization ofG-quadruplex by dinuclear RuII complex Ru2(obip)L4,Inorganic Chemistry, 2008, 47 (8),2910-2912.

3. ShuoShi, Cai-Ping Tan, Jie Liu, and Liang-Nian Ji*, Conformation conversion andstabilization of G-quadruplex by dinuclear RuII complex [(bpy)2Ru(obip)Ru(bpy)2]4+,Journal ofBiomolecular Structure Dynamics, 2007, 24, 706.

2. ShuoShi, Jie Liu*, Jun Li, Kang-Cheng Zheng, Xiao-Mei Huang, Cai-Ping Tan, Lan-MeiChen and Liang-Nian Ji*, Synthesis, characterization and DNA-binding of novelchiral complexes D- and L- [Ru(bpy)2L]2+(L= o-mopip andp-mopip), Journal of Inorganic Biochemistry, 100 (2006)385–395.

1. ShuoShi, Jie Liu*, Jun Li, KangC. Zheng, Cai P. Tan, Lan M. Chen and Liang N. Ji*,Electronic effect of different positions of the –NO2 group on theDNA-intercalator of chiralcomplexes [Ru(bpy)2L]2+ (L =o-npip, m-npip and p-npip), Dalton Trans., 2005, 2038– 2046.