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王奕,博士,同济大学医学院、同济大学附属上海市养志康复医院副教授,博士研究生导师,上海市“启明星”计划青年人才,上海市公共卫生建设计划优秀青年人才。自博士研究生阶段起从事包括艾滋痴呆症、阿尔茨海默症等神经退行性疾病致病机制的基础研究及临床研究设计,以及神经伦理学研究,近五年在Neuron等一流学术期刊上发表论文三十余篇,获包括国自然青年基金在内的纵向项目多项,任中国康复协会阿尔茨海默病专委会委员。
1. 国家自然科学基金委员会, 青年科学基金项目,81801063, 谷氨酰胺酶在介导阿兹海默神经炎症中的作用及其治疗应用研究, 2019-01-01 至 2021-12-31, 21万元, 已结题, 主持。
2. 上海市科学技术委员会,“科技创新行动”青年启明星人才计划,23QA1408400,外泌体miR-381介导的神经元与小胶质细胞互作在阿尔茨海默病发生发展中的作用及机制研究,2023-04-01至2026-03-31,40万元,在研,主持。
3. 上海市卫生健康委员会, 公共卫生体系建设三年行动计划(2020-2022年)优秀青年人才培养计划, GWV-10.2-YQ47, 痴呆症模型小鼠的建立与药物疗效评估, 2021-01-01 至 2022-12-31, 18万元, 在研, 主持。
4. 上海市卫生健康委员会, 基础科研课题, 20204Y0031,谷氨酰胺酶抑制剂治疗肺炎细胞因子风暴的可行性研究, 2021-01-01 至 2023-12-31, 5万元, 在研,主持。
5. 国家自然科学基金重点项目,81830037,谷氨酰胺酶C亚型介导的小胶质细胞激活在阿尔兹海默病神经炎症的机制解析,2019-01-01 至 2023-12-31,293万元,在研,参与。
1. Gao Gǂ, LiCǂ, Ma Yǂ, LiangZǂ, Li Y, Li X, Fu S, Wang Y*, Xia X*, ZhengJC*. Internal m7G methylation: a novel epitranscriptomic contributor inbrain development and diseases. Mol Ther-Nucl Acids. 2023; 31:295-308. Neuralstem cell-derived extracellular vesicles mitigate Alzheimer’s disease-likephenotypes in a preclinical mouse model. Signal Transduct Tar. 2023. June 14.
2. XiaXǂ*,Wang Yǂ,Zheng JC*. Internal m7G methylation: a novel epitranscriptomic contributorin brain development and diseases. Mol Ther-Nucl Acids. 2023; 31:295-308.
3. LiX, Zhu Y, Wang Y*, Xia X*, Zheng JC*. Neural stem/progenitor cell-derivedextracellular vesicles: a novel therapy for neurological diseases and beyond.Medcomm. 2023; 4(1):e214.
4. Xia Xǂ*, WangYǂ, ZhengJC*. Extracellular vesicles, from the pathogenesis to the therapy ofneurodegenerative disease. Transl.Neurodegener. 2022.Dec12;11(1):53.
5. Wang Yǂ, Yuan Pǂ,Ding L, Zhu J, Qi X, Zhang Y, Li Y, XiaX*, Zheng JC*, Circulating extracellularvesicle–containing microRNAs reveal potential pathogenesis of Alzheimer’sdisease. Front Cell Neurosci. 2022.10.22
6. Xia Xǂ*, WangYǂ, ZhengJC*. The microRNA-17~92 family as a key regulator of neurogenesisand potential regenerative therapeutics of neurological disorders. Stem Cell Rev Rep.2022; 18(2):401-411
7. Wang Yǂ,Xia Xǂ*, Therole of Exosomes in neuroinflammation and neurodegeneration. Front CellNeurosci. 2022
8. Pan Jǂ, Sheng Sǂ, Ye Lǂ, Xu X, MaY, Feng X, Qiu L, Fan Z, Wang Y*, Xia X*,Zheng JC*. Extracellular vesicles derived from glioblastomapromote proliferation and migration of neural progenitor cells via PI3K-Aktpathway. Cell. Commun. Signal. 2022 Jan 12;20(1):7
9. Ding Lǂ, Xu Xǂ, Li Cǂ, WangY*, Xia X*, Zheng JC*. Glutaminasein microglia: a novel regulator of neuroinflammation. Brain Behav Immun. 2021;92:139-156.
10.Xia Xǂ*, Wang Yǂ, Zheng JC*. COVID-19 and Alzheimer'sdisease: how one crisis worsens the other. Transl. Neurodegener. 2021; 10(1):15.
11.Xia Xǂ*, WangYǂ, ZhengJC*. Emerging roles of extracellularvesicles in mediating RNA virus infection. Fundamental Research. 2021; 2(1):179-185
12.Wang Y, Yin J, Wang G, Li P, Bi G,Li S, Xia X, Song J, Pei G*, Zheng JC*. Responsibilityand Sustainability inBrain Science, Technology, and Neuroethics in China-a Culture-Oriented Perspective. Neuron 2019; 6; 101:375-379
13.Gao Gǂ, Zhao Sǂ, Xia Xǂ, Li C, Li C, Ji C,Sheng S, Tang Y, Zhu J, Wang Y*, Huang Y*, Zheng JC*. GlutaminaseC regulates microglia activation and pro-inflammatory exosome release:relevance to the pathogenesis of Alzheimer’s disease. Front. Cell. Neurosci. 2019; 13:264
14.Wang Yǂ; Li Yǂ; Zhao Rǂ; Wu B; Lanoha B; Tong Z; Peer J; Liu J; Xiong H;Huang Y*; Zheng JC*. Glutaminase C overexpression in the brain induces learningdeficits, synaptic dysfunctions, and neuroinflammation in mice. Brain BehavImmun. 2017, 66: 135-145
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