获得十余项国家级或省部级科研项目。

获得十余项国家级或省部级科研项目。

在PNAS、Dev Cell、JASN等高影响力期刊发表论文近40篇，获得专利一项。

1.     Wenyan Xu, Miaomiao Jin, Ruikun Hu, Hong Wang, Fan Zhang, Shiaulou Yuanand Ying Cao*. The Joubert Syndrome Protein Inpp5eControls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. Journal of the American Society ofNephrology, 2017 Jan;28(1):118-129. (highlightedin Nature Reviews Nephrology,2016, 12: 508)

2.     Zhang, Haijiao; Lin, Lin; Liu, Jianping; Pan, Lifeng; Lin, Zhijie; Zhang,Mingjie; Zhang, Jiong; Cao, Ying; Zhu, Jinwei*; Zhang,Rongguang*. Phase Separation of MAGI2-Mediated Complex Underlies Formation ofSlit Diaphragm Complex in Glomerular Filtration Barrier. Journal of theAmerican Society of Nephrology, 2021, 32(8): 1946-1960. DOI:10.1681/ASN.2020111590

3.     Miaomiao Jin#, Jingyu Li#, Ruikun Hu, Baijie Xu, Guanliang Huang, WeilaiHuang, Bo Chen, Jie He & Ying Cao*. CyclinA2/cyclin-dependent kinase 1–dependent phosphorylation of Top2a is required forS phase entry during retinal development in zebrafish. Journal of Geneticsand Genomics. 2021 Jan 20; 48(1): 63-74. doi:10.1016/j.jgg.2021.01.001."

4.     Hanjing Wei, Yanhua Xu, Yibin Wang, Liting Xu, Chunyang Mo, Liangzi Li, BoShen, Yao Sun, Pengzhen Cheng, Liu Yang, Yichuan Pang, An Qin, Ying Cao,Sean J Morrison, Rui Yue*. Identification of Fibroblast Activation Protein asan Osteogenic Suppressor and Anti-osteoporosis Drug Target. Cell Rep.2020 Oct 13;33(2):108252.

5.     Xueyu Li, Qiang Lu, Yuanyuan Peng, Fang Geng, Xuelian Shao, Huili Zhou, YingCao & Ruilin Zhang*. Primary cilia mediate Klf2-dependant Notchactivation in regenerating heart. Protein & Cell 2020Jun;11(6):433-445. doi: 10.1007/s13238-020-00695-w.

6.     Jian Zhu, Han-Tsing Wang, Yu-Rong Chen, Ling-Ya Yan, Ying-Ying Han,Ling-Yan Liu, Ying Cao, Zhi-Zhi Liu, Hong A Xu. The JoubertSyndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish.Neurosci. Bull. September, 2020, 36(9):1023–1034

7.     Yonghua Sun, Bo Zhang, Lingfei Luo, De-Li Shi, Han Wang, Zongbin Cui,Honghui Huang, Ying Cao, Xiaodong Shu, Wenqing Zhang, JianfengZhou,Yun Li, Jiulin Du, Qingshun Zhao, Jun Chen, Hanbing Zhong, Tao P. Zhong,Li Li, Jing-Wei Xiong, Jinrong Peng, Wuhan Xiao, Jian Zhang, Jihua Yao, ZhanYin, Xianming Mo, Gang Peng, Jun Zhu, Yan Chen, Yong Zhou, Dong Liu, WeijunPan, Yiyue Zhang, Hua Ruan, Feng Liu, Zuoyan Zhu, Anming Meng, and The ZAKOCConsortium. Systematic genome editing of the genes on zebrafish Chromosome 1 byCRISPR/Cas9. Genome Research, 2020.

8.     Yufei Feng, Ping Yu, Jingyu Li, Ying Cao, Jingjing Zhang.Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafishotic vesicle. Journal of Genetics and Genomics, 2020 Oct20;47(10):627-636.

9.     Miaomiao Jin, Wenyan Xu, Hong Wang and Ying Cao*. Claudin-7band Claudin-h are required for controlling cilia morphogenesis in the zebrafishkidney. Mechanisms of Development. 2020 Mar;161:103595. doi:10.1016/j.mod.2019.103595. Epub 2019 Dec 27.

10.  Yongzhan Sun, Zhiheng Liu, Xinyi Cao, Yi Lu, Zeyun Mi, Chaoran He, JingLiu, Zhanye Zheng, Mulin Jun Li, Tiegang Li, Dechao Xu, Ming Wu , YingCao, Yuhao Li, Baoxue Yang, Changlin Mei, Lirong Zhang, Yupeng Chen.Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystickidney disease. SCIENCE ADVANCES. 2019; 5 : eaaw3593

11.  Ruikun Hu, Weilai Huang, Miaomiao Jin, JiangfangLiu, Yue Wu,Jingyu Li, Zehao Yu, Hong Wang, and YingCao*. Mutagenesis of ciliary candidate genes with CRISPR/Cas9 system inzebrafish identifies genes required for retina development. FASEB J. 2019

12.  Wenyan Xu, Miaomiao Jin, Weilai Huang, Ruikun Hu, Hong Wang, Jingyu Li andYing Cao*. ApicalPtdIns(4,5)P2 is required for ciliogenesis and suppression of polycystic kidneydisease. FASEB J. 2019

13.  R. Sun, Y. Wang, M. Jin, L. Chen1, Y.Cao*, and F. Chen*. Identification and Functional Studies of MYO1H forMandibular Prognathism. Journal of Dental Research, 2018: 1–9 (*共通讯)

14.  Xu D, Lv J, He L, Fu L, Hu R, CaoY*, Mei C*. Scribble influences cyst formation in autosomal-dominantpolycystic kidney disease by regulating Hippo signaling pathway. FASEB J. 2018 Mar. (*共通讯)

15.  Yunru Chen, Shiyang Zeng, Ruikun Hu, Weilai Huang, Xiangxiu Wang,Jiangfang Liu, Luying Wang, Guifen Liu, YingCao* and Yong Zhang*. Using local chromatin structure to improveCRISPR/Cas9 efficiency in zebrafish. PLoSOne，2017 Aug 11，12(8):e0182528. (*共通讯)

16.  Yonghua Sun, Bo Zhang, LingfeiLuo, De-Li Shi, Han Wang, Zongbin Cui, Honghui Huang, Ying Cao, Xiaodong Shu, Wenqing Zhang, Jianfeng Zhou, YunLi, Jiulin Du, Qingshun Zhao, Jun Chen, Hanbing Zhong, Tao P. Zhong, Li Li,Jing-Wei Xiong, Jinrong Peng, Wuhan Xiao, Jian Zhang, Jihua Yao, Zhan Yin,Xianming Mo, Gang Peng, Jun Zhu, Yan Chen, Yong Zhou, Dong Liu, Weijun Pan,Yiyue Zhang, Hua Ruan, Feng Liu, Zuoyan Zhu, Anming Meng, and The ZAKOCConsortium. Systematic genome editing of the genes on zebrafish Chromosome 1 byCRISPR/Cas9. Genome Research, 2020.

17.  Xueqian Wang, Haitao Hou, Kaida Song, Zhiqiang Zhang, Shuqiang Zhang, Ying Cao, Liming Chen, QingSang, Fang Lin and Hui Xu. (2018). Lpar2b Controls Lateral Line Tissue Size byRegulating Yap1 Activity in Zebrafish. Frontiers in Molecular Neuroscience,

18.  Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkey D, YuY, Tang J, Flockerzi V, Cao Y,Cao E, Chen XZ. Hydrophobic pore gates regulate ion permeation in polycystickidney disease 2 and 2L1 channels. Nat Commun. 2018 Jun 13;9(1):2302.

19.  Zheng W, Hu R, Cai R, Hofmann L, Hu Q, Fatehi M, Long W, Kong T, Tang J,Light P, Flockerzi V, Cao Y,Chen XZ. Identification and characterization of hydrophobic gate residues inTRP channels. FASEB J. 2018Feb;32(2):639-653

20.  Xiaoyu Zhao, Miaomiao Jin, Mengzhu Wang, Lili Sun, Xuejiao Hong, Ying Cao & Chunguang Wang. Fidgetin-like1 is a ciliogenesis-inhibitory centrosome protein. Cell Cycle. 2016Sep;15(17):2367-75.

21.  Wang Zheng, Fan Shen, Ruikun Hu, Birbickram Roy, JungWoo Yang, Qian Wang,Fan Zhang, Jennifer C. King, Consolato Sergi, Song-Mei Liu, Emmanuelle Cordat,Jingfeng Tang, Ying Cao, Declan Ali and Xing-Zhen Chen. FarUpstream Element-Binding Protein 1 Binds the 3' Untranslated Region of PKD2 andSuppresses Its Translation. Journal ofthe American Society of Nephrology 2016; 27

22. Liangliang He, Wenyan Xu,Ying Jing, Ming Wu, Shuwei Song, Ying Cao*, Changlin Mei*.Yes-Associated Protein (Yap) Is Necessary for Ciliogenesis and Morphogenesisduring Pronephros Development in Zebrafish (Danio Rerio). Int J Biol Sci2015; 11(8):935-947. （*共通讯）

23.  Hussein S, Zheng W, Dyte C,Wang Q, Yang J, Zhang F, Tang J, Cao Y, Chen XZ. Acid-induced off-responseof PKD2L1 channel in Xenopus oocytes and its regulation by Ca(2.). Sci Rep.2015 Oct 27;5:15752. doi: 10.1038/srep15752.

24.  Zheng W, Hussein S, Yang J,Huang J, Zhang F, Hernandez-Anzaldo S, Fernandez-Patron C, Cao Y, Zeng H, Tang J, Chen XZ. A novel PKD2L1 C-terminaldomain critical for trimerization and channel function. Sci Rep. 2015 Mar 30;5:9460

25.  Ma X, Chen Y, Xu W, Wu N, Li M,Cao Y, Wu S, Li Q, Xue L. ImpairedHippo signaling promotes Rho1-JNK-dependent growth. PNAS, 2015 Jan 27;112(4):1065-70.

26.  Zhao L, Yuan S, Cao Y, Kallakuri S, Li Y,Kishimoto N, Dibella L, Sun Z.Reptin/Ruvbl2 is a Lrrc6/Seahorse interactoressential for cilia motility. PNAS,110(31):12697-702

27.  Cao, Y#, Park, A. and Sun, Z. (2010). IntraflagellarTransport Proteins Are Essential for Cilia Formation and for Planar CellPolarity. J Am Soc Nephrol.21(8):1326-33. (封面文章)

28.  Cao, Y.#, Semanchik N, Lee SH, Somlo S, Barbano PE, Coifman R, Sun Z. (2009).Chemical modifier screen identifies HDAC inhibitors as suppressors of PKDmodels. PNAS, 106(51):21819-21824

29.  Kishimoto, N., Cao, Y.,Park, A., and Sun, Z. (2008). Cystic Kidney Gene seahorse RegulatesCilia-Mediated Processes and Wnt Pathways. Dev Cell, 14:954-961.

30.  Rui, Y.#, Xu, Z.#, Xiong, B.#, Cao,Y.#, Lin, S., Zhang, M., Chan, SC., Luo, W., Han, Y., Lu, Z., Ye, Z.,Zhou, HM., Han, J., Meng, A., and Lin, SC. (2007). A beta-catenin-independentdorsalization pathway activated by Axin/JNK signaling and antagonized by aida. DevCell, 13(2):268-82. (#并列第一作者)

31.  Huang, H., Lu, F., Jia, S.,Meng, S., Cao, Y., Wang, Y., Ma, W., Yin, K., Wen, Z., Peng, J.,Thisse, C., Thisse, B., and Meng, A. (2007). Amotl2 is essential for cellmovements in zebrafish embryo and regulates c-Src translocation. Development,134:979-988.

32.  Cao, Y.#, Zhao, J., Sun, Z., Zhao, Z., Postlethwait, J., and Meng, A.(2004). fgf17b, a novel member of Fgf family, helps patterning zebrafishembryos. Dev Biol, 271:130-143.

33.  Zhao, J., Cao, Y.,Zhao, C., Postlethwait, J., and Meng, A. (2003). An SP1-like transcriptionfactor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. EmboJ, 22:6078-6088.

34.  Cao, Y.#, Zhao, J., Wang, Y., and Meng, A. (2003). Expression of zebrafishLc3 synthase gene in embryonic lens requires hedgehog signaling. Dev Dyn,228:308-312.

35.  Li, M., Cao, Y., Zhao, Z., Lin, S., and Meng, A. (2001). Characterizationand expression pattern of pouII1 , a novel class II POU gene in zebrafish. Chin Sci Bull, 46(18):1523-1527.

36.  Zhao, Z.#, Cao, Y.#,Li, M., and Meng, A. (2001). Double-stranded RNA injection produces nonspecificdefects in zebrafish. Dev Biol, 229:215-223. (#并列第一作者)

专利：

曹莹，王宏，许纹衍。一种磷脂酰肌醇3-激酶抑制剂的应用。2019。专利号：ZL 2015 1 0171337.3