同济大学
导师风采
彭艾
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个人信息

Personal Information

  • 教授
  • 导师类别:硕士,博士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

联系方式

Contact Information

  • 所属院系:医学院
  • 所属专业: 内科学
  • 邮箱 : pengai@tongji.edu.cn
  • 工作电话 : 021-66302524

个人简介

Personal Profile

2000年南京大学医学院南京军区总医院博士毕业,现为同济大学附属第十人民医院肾脏科主任, 主任医师,博士生导师,博士后,美国德克萨斯大学西南医学中心访问教授,863基金首席专家,同济大学肾脏病代谢组学研究中心主任,学科带头人。主要学术任职包括:国际体外技术治疗中毒(EXTRIP)专家组成员,中国毒理学会中毒与救治专业委员会常委,上海市康复学会肾脏病分会副主任委员,上海市医学会肾脏病分会委员,上海市医师协会肾脏内科医师分会委员,中国非公医疗协会肾脏病专业委员会委员,上海市肾脏病质控委员,以负责人承担863基金1项、国家自然科学基金多项。主要研究方向:高尿酸痛风肾病发病机制,中毒的血液净化治疗。临床擅长:痛风肾病诊治、药物毒物中毒患者的透析治疗,泌尿道微结石的防治,糖尿病肾病早期诊断治疗。抢救325例重度百草枯中毒成功率超过72.7%。率先开展肾脏微血管功能超声检测技术和无创肾组织弹性特征的评估技术研究。以负责人承担863基金1项、国家自然科学基金(NSFC) 6项、上海市自然科学基金1项。曾在中国大学生应用科技大奖赛中获三等奖; 2004年获“复旦大学博士后学术演讲比赛”第二名;2007年获复旦大学优秀博士后;2010年获教育部科技进步二等奖。在Kidney Int (IF=18.8), Crit Care Med (IF=9.26),Cell Report 等国内外知名杂志发表论文SCI 100余篇, 获国家发明专利2项,国家实用新型专利1项,转化专利1项。


  • 研究方向Research Directions
高尿酸痛风发病机制,,中毒的血液净化治疗
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
科研项目

2004-2005 “足细胞损伤在肾小球硬化中的作用” 获2004年35届中国博士后基金二等资助(编号:2004350118),为负责人,结题。

2004-2006  “黄芪促肾脏水钠排泄基因差异表达的研究” 该课题获2004年国家自然科学基金资助(编号:30472163),为负责人,已结题。

2006-2008  “肾小球Dystroglycan在足细胞脱落中的作用” 该课题获2006年上海市自然科学基金资助(编号:06ZR14161),为负责人,已结题。。

2009-2011“Amylin在糖尿病血管内皮屏障功能损伤中的作用和机制研究” 获2008年国家自然科学基金资助(30871202),为负责人,已结题。

2009-2011 “糖尿病肾损伤尿液肾脏上皮细胞分析的临床意义”获国际高新技术发展计划(863计划)资助(编号:2009AA02Z416),为课题负责人(首席专家),已结题。

2012-2015  “PI3K/AKT/mTOR 信号通路激活致Ddit4 基因高表达是百草枯肺损伤的主要分子机制”获2012年国家自然科学基金资助(30871202),为负责人,目前在研。

2013-2016  “Nlrc5异常表达在急性肺损伤中的作用及靶向机制研究”获2012年国家自然科学基金资助(81270136),为负责人。

2019-2023 “PSTK基因/GPx-1/过氧化氢信号通路异常百草枯所致肺损伤的重要机制”获2016年国家自然科学基金资助(81671897),为负责人

2019-2023 “XOR介导肺泡巨噬细胞极化在百草枯肺损伤中的作用及机制研究” 获2012年国家自然科学基金面上项目资助(81971822),为负责人。

2017-2019重大疾病的防控策略、诊疗规范及其效果评价研究-慢性肾脏疾病的临床研究和推广应用. 科技部支撑计划(2017BA112B05)子课题负责人。


研究成果

(1)  Hanjie Yu*, Wen Xue *, Ling Wang*, Hanqing Yu, Yaxiang Song, XingyingLiu, Ling Qin, Shu Wang, Hui Bao, Hongchen Gu, Guangqi Chen, Dake Zhao, JiafengCheng, Liya Wang, Dayong Hu and Ai Peng*. Single-cell RNA sequencingreveals monocyte subtypes and Treg cells contribute to gout flare and remission.JCI Insight accepted

(2)  Hongchen Gu, Hanqing Yu, Ling Qin, Wen Xue, Ling Wang, ZishengAi, Peng Ai*. Single-cell RNA sequencing ofperipheral blood mononuclear cells in gout remission patients with MSU crystaldeposition. Cell Rep. 2023 Sep 26; 42(10):113139.

(3)  Shijie Wu M.D# 1, Wen Xue M.D# 1,Hanqing Yu M.D1, Hanjie Yu M.D1, Zhaoqiang Shi M.D 1,Ling Wang M.D* 1, Ai Peng M.D* 1Relationships Between Serum Uric Acid Concentrations and Long-term Health OutcomesAmong CKD patients: A Prospective Cohort Study. Nephrol Dialysis Transplant.2023 accepted.

(4)  Yu H,  Xue W,  Yu H,  Gu H,  Qin L,  Peng A*,Joint Application of Multiple Inflammatory Cytokines in Diagnosis of GoutFlare. J Inflamm Res 2023;16

(5)  Wang H, Ainiwaer A, Song Y, QinL, Peng A, Bao H, Qin H. Perturbed gut microbiome and fecaland serum metabolomes are associated with chronic kidney disease severity.Microbiome. 2023 Jan 9;11(1):3. 

(6)  Zhang H, Li G, Yu X, Yang J,Jiang A, Cheng H, Fu J, Liang X, Liu J, Lou J, Wang M, Xing C, Zhang A, ZhangM, Xiao X, Yu C, Wang R, Wang L, Chen Y, Guan T, Peng A, Chen N,Hao C, Liu B, Wang S, Shen D, Jia Z, Liu Z; China Dialysis Calcification StudyGroup. Progression of Vascular Calcification and Clinical Outcomes in PatientsReceiving Maintenance Dialysis. JAMA Netw Open. 2023 May 1;6(5):e2310909.

(7)  Bouchard J, Yates C, CalelloDP, Gosselin S, Roberts DM, Lavergne V, Hoffman RS, Ostermann M, Peng A,Ghannoum M; EXTRIP Workgroup. Extracorporeal Treatment for Gabapentin andPregabalin Poisoning: Systematic Review and Recommendations From the EXTRIPWorkgroup. Am J Kidney Dis. 2022 Jan;79(1):88-104

(8)  Yu H,  Zhou C,  Hu D,  Li C,  Wang Q,  Xue W,  Peng A*,.Uremic toxin indoxyl sulfate induces dysfunction of vascular smooth musclecells via integrin-β1/ERK signaling pathway. Clin Exp Nephrol. 2022 Jul; 26(7):640-648.

(9)  Chen G,  Cheng J,  Yu H,  Huang X,  Bao H,  Qin L,  Wang L,  Song Y,  Liu X,  Peng A*,Quantitative proteomics by iTR Quantitative proteomics by iTRAQ-PRM basedreveals the new characterization for gout. Proteome Sci. 2021 Oct11;19(1):12

(10) Wu M, Zhou C, Li M, Yu H, Zhao D, Xue W, Qin L, Peng A*. Depletion of NK cells attenuatesparaquat-induced acute lung injury by manipulating macrophage polarization.Int Immunopharmacol. 2020;86:106698.

(11) Wang S, Wu M, Qin L, Song Y, Peng A*. DAXX mediates high phosphate-inducedendothelial cell apoptosis in vitro through activating ERK signaling.PeerJ. 2020 Jun 19;8:e9203.

(12)Song YX, Fan SL, Peng A, Shen S, Cheng JF, Chen GQ, LiCB, Jiang C, Li XH, Liu JY. A retrospective analysis reveals a predictor of survival for the patientwith paraquat intoxication. Clin Chim Acta. 2020 Dec;511:269-277.

(13) Wan X, Li X, Wang Q, Zheng B, Zhou C, Kang X, Hu D, Bao H, Peng A*. Metabolitic profiling of amino acidsin paraquat-induced acute kidney injury. Clin Exp Nephrol.2019;23(4):474-483.

(14) Li C, Hu D, Xue W, Li X, Wang Z, Ai Z, Song Y, Liu X, Cheng J, FanS, Zhao L, Wang L, Mohan C, Peng A*. Treatment Outcome of CombinedContinuous Venovenous Hemofiltration and Hemoperfusion in Acute ParaquatPoisoning: A Prospective Controlled Trial. Crit Care Med. 2018;46(1):100-107.

(15) Wan X, Zhou C, Kang X, Hu D, Xue W, Li X, Bao H, Peng A*.Metabolic Profiling of Amino AcidsAssociated with Mortality in Patients with Acute Paraquat Poisoning.Med Sci Monit. 2018;24:1397-1407. 

(16) Wu M, Kang X, Wang Q, Zhou C, Mohan C, Peng A*. Regulator ofG protein signaling-1 modulates paraquat-induced oxidative stress and longevityvia the insulin like signaling pathway in Caenorhabditis elegans. Toxicol Lett.2017;273:97-105.

(17) Wang Q, Liu S, Hu D, Wang Z, Wang L, Wu T, Wu Z, Mohan C, Peng A*.Identification of apoptosis and macrophage migration events in paraquat-inducedoxidative stress using a zebrafish model. Life Sci. 2016;157:116-124.

(18) Liu S, Wang Q, Zhou R, Li C, Hu D, Xue W, Wu T, Mohan C, Peng A*.Hyperamylasemia as an Early Predictor of Mortality in Patients with AcuteParaquat Poisoning. Med Sci Monit. 2016;22:1342-1348.

(19) Bao H, Peng A*. The Green TeaPolyphenol(-)-epigallocatechin-3-gallate and its beneficial roles in chronickidney disease. J Transl Int Med. 2016 Sep 1;4(3):99-103.

(20) Chun-Yu Zhou,Xin Kang, Chang-Bin Li,Xin-Hua Li,Yong Liu, Zhen Wang, Ling Wang, Tianfu Wu, Chandra Mohan,Da-Yong Hu& Ai Peng*.Pneumomediastinum predicts early mortality in acute paraquat poisoning. ClinToxicol (Phila). 2015; 53(6): 551-556.

(21) Xu Wei, Wang Ling, Wang Qian, Li XinHua, Hu Dayong, Li Changbin, Wu Tianfu,Mohan Chandra, Peng Ai*, Shi Yuling. Paraquat Poisoning Followed byToxic Epidermal Necrolysis: A Report of Two Cases and Published Work Review.Dermatology. 2015;231(3):209-212.

(22) Dong Zheng, Changbin Li , ShuWang, Yanqing Cang, Yaxiang Song, XinyingLiu, Xinhua Li, Chandra Mohan ,Tianfu Wu , Dayong Hu, Ai Peng*. PSTK isa novel gene associated with early lung injury in Paraquat Poisoning. Life Sci.2015;123:9-17.

(23) Xin Kang,Da-Yong Hu,Chang-Bin Li, Xin-Hua Li, Shu-Ling Fan, Yong Liu, Guang-Yu Tang, Zi-ShengAi, Tianfu Wu, Chandra Mohan, Xin J. Zhou, Jun-Yan Liu, Peng Ai*. Thevolume ratio of ground glass opacity in early lung CT predicts mortality inacute paraquat poisoning. PLoS One. 2015;10(4):e0121691.

(24) Ai Peng,Ting Ye, Dinesh Rakheja, Zhao Hu, Yangke Tu, Tao Wang, Yong Du,Nosratola D. Vaziri, Chandra Mohan and Xin J. Zhou. Green tea polyphenol(-)-epigallocatechin-3-gallate (EGCG) ameliorates experimental immune-mediatedglomerulonephritis. Kidney Int. 2011; 80(6):601-11. Comment in: Kidney Int. 2011;80(6):563-564.

(25) 李昌斌, 李新华, 王贞, 姜成华, 彭艾*. 分光光度法检测血浆百草枯质量浓度及意义. 中华急诊医学杂志. 2011, 20(8):845-850.

(26) Chang-bin Li, Xin-hua Li, Zhen Wang, Cheng-hua Jiang, Peng Ai*.Serum paraquat concentration detected by spectrophotometry in patients withparaquat poisoning. World J Emerg Med. 2011, 2(3): 179-184.

(27) 李丽,彭艾*,朱开元,于宏,李新华,李昌斌. 金属催化氧化作用对高级氧化蛋白产物(AOPPs)生成的影响. 中华医学杂志 2008;88(8):1-5.

(28) Peng Ai, Meng Fanqing, Sun Lanfang, JiZhanshen, Li YuHong. Reduced Mortality of Severe Dichlorvos Poisoning byHemoperfusion with Activated Charcoal. Acta Pharmacologica Sinica, 2004 ; 25(1):15-21.

(29) Darren M Roberts, Peng Ai, Zhu Kaiyuan, Nicholas A Buckley.Extracorporeal blood purification for acute organophosphorus pesticidepoisoning. J Intensive Care Med. 2007; 22(2):124-126.

(30) 彭艾,孙连增,李玉会. 血液灌流治疗急性重度敌敌畏中毒病人的观察.中华内科杂志,2000,39(10):699~700.

(31) 彭艾,刘志红,张真,张鑫,苏健,黎磊石. 毒鼠强中毒致肾毒性损伤的临床特征.肾脏病与透析肾移植杂志.2003;12(2):118~123.

(32) Fang Ma1*, Yanqin Cang2*, Baozhen Zhao3#,Yuanyuan Liu1, Chaoqing Wang1, Bo Liu1, TianfuWu2, Ai Peng2#. Contrast-EnhancedUltrasound with SonoVue could accurately assess the renal microvascularperfusion in diabetic kidney damage. Nephrol Dial Transplant. (accepted) 2011

(33) Ai Peng*(第一作者), Tianfu Wu*, Caihong Zeng,Dinesh Rakheja, Zhihong Liu, Jiankun Zhu, Nosratola D. Vaziri, Chandra Mohan and Xin J. Zhou. Adverseeffects of simulated hyper- and hypo-phosphatemia on endothelial cell functionand viability. PLoS One. 2011;6(8):e23268(SCI )

(34) Ai Peng(第一作者), Ting Ye, Dinesh Rakheja, ZhaoHu, Yangke Tu, Tao Wang, Yong Du, Nosratola D. Vaziri, Chandra Mohan and Xin J. Zhou. Green tea polyphenol(-)-epigallocatechin-3-gallate (EGCG) ameliorates experimental immune-mediatedglomerulonephritis. Kidney Int. 2011; 80(6):601-11.  Comment in: Kidney Int. 2011;80(6):563-4(SCI)

(35) Lu H*, Zhen J*, Wu T*, Peng A, Ye T, Wang T, Yu X,Vaziri ND, Mohan C, Zhou XJ Superoxide dismutase mimetic drug tempol aggravatesanti-GBM antibody induced glomerulonephritis in mice. Am J Physiol Renal Physiol. 2010; 299 (2):445-452. (SCI )

(36) Ai P, (第一作者)Yong G,Dingkun G, Qiuyu Z, Kaiyuan Z, Shanyan L. Aqueous extract of Astragali Radixinduces human natriuresis through enhancement of renal response to atrialnatriuretic peptide. J Ethnopharmacol. 2008; 116: (3): 413-421(SCI )

(37) Gong W, Liu ZH, Zeng CH, PengA  Chen HP, Zhou H, Li LS. Amylindeposition in the kidney of patients with diabetic nephropathy. Kidney Int.2007;72(2):213-218.(SCI )

(38) Peng A(第一作者), Liu ZH,Zhou H, Zhu MY, Li LS. Fibrillogenic amylin evokes the apoptosis of humanmesangial cells. Diabetes Res Clin Pract. 2007;78(1):16-22.(SCI )

(39) Roberts DM, Peng A, Zhu K, Buckley NA. Extracorporeal bloodpurification for acute organophosphorus pesticide poisoning. J Intensive CareMed. 2007;22(2):124-6.

(40) Peng A(通讯作者,第一作者),Meng FQ,Sun LF,Ji ZS,Li YH. Reduced Mortality of Severe Dichlorvos Poisoning byHemoperfusion with Activated Charcoal. Acta Pharmacol Sin 2004;25(1):15-21.(SCI)

(41) Peng A, Gu Yong, Lin Shanyan. Herbal treatment for renal diseases. AnnalsAcademy of Medicine Singapore 2005,34(1): 23-27 (SCI)

(42) Ma J, Peng A, Lin SY. Mechanisms of the therapeutic effect ofastragalus membranaceus on sodium and water retention in experimental heartfailure. Chin Med J (Engl). 1998; 111(1):17-23 (SCI 收录)

(43) Peng A HaoCM,Lin SY, Li P. Effect of microinjection of A II into area postrema on renalsodium excretion. Acta Physiologica Sinica 1996,48(5):417-422

 发明专利2项,其中转化1项


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