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赵琳琳研究员致力于探索肿瘤免疫领域重要细胞膜受体的分子机制,利用生物物理学、细胞生物学、生物化学等多学科交叉背景,建立了从受体蛋白动态成像、细胞功能机制鉴定到靶向抗体筛选的完整研究体系,先后在Cell, Cell Research, Nature Structural & Molecular Biology, Structure, Protein Cell, Biochemistry等重要期刊发表高水平论文。
(1)国家自然科学基金青年项目,32301027,2024年1月-2026年12月,在研,主持
(2)上海市卫健委学科带头人(青年),2022YQ079,2023年1月-2025年12月,在研,主持
(3)同济大学百人计划,22002150002,2021年10月-2025年12月,在研,主持
1. Pan, L.*, Fu, T. M.*, Zhao, W.*, Zhao, L.*, Chen, W., Qiu, C., ... & Chen, S. (2019). Higher-order clustering of the transmembrane anchor of DR5 drives signaling. Cell, 176(6), 1477-1489.
2. Du, G.*, Zhao, L.*, Zheng, Y., Belfetmi, A., Cai, T., Xu, B., Heyninck, K., Van Den Heede, K., Buyse, M.A., Fontana, P. and Bowman, M., (2023). Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell Research, pp.1-16.
3. Zhao L, Fu Q, Pan L, Piai A, Chou JJ. (2020). The diversity and similarity of transmembrane trimerization of TNF receptors. Frontier Cell Dev Biol, 8, 1096.
4. Zhao, L., Wang, S., Zhu, Q., Wu, B., Liu, Z., OuYang, B., & Chou, J. J. (2017). Specific interaction of the human mitochondrial uncoupling protein 1 with free long-chain fatty acid. Structure, 25(9), 1371-1379.
5. Zhao, L.*, Wang, S.*, Run, C., OuYang, B., & Chou, J. J. (2016). Specific lipid binding of membrane proteins in detergent micelles characterized by NMR and molecular dynamics. Biochemistry, 55(38), 5317-5320.
6. Zhao, L., Wang, S., Du, L., Dev, J., Zhou, L., Liu, Z., ... & OuYang, B. (2016). Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride. Protein & cell, 7(4), 300-304.
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