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同济大学教授,入选同济大学“百人计划”,国家自然科学基金优青,中国科协青年人才托举工程和上海市青年科技启明星计划等,并荣获第四届青年人才托举工程典型代表人物。依托同济大学癌症中心、同济大学医学院肿瘤微环境研究所和同济大学附属第十人民医院中心实验室等科研基地,主要研究肿瘤免疫微环境重塑的作用机制及功能。研究成果以第一或通讯(含共同)作者发表在Cancer Cell(2023,2018)、Molecular Cell、Cell Death &Differentiation、STTT和Cell Discovery等杂志。已承担国家重点研发青年科学家项目、国家自然科学基金面上项目和青年项目,上海市创新行动计划等。兼任中国抗癌协会肿瘤微环境专业委员会和中国细胞生物学肿瘤细胞生物学分会青年委员。
1、上海市静安区中青年拔尖人才,2022/01-2024/12,15万元,在研,项目负责人。
2、国家重点研发计划青年科学家项目,2021YFA1302200,基于小分子调控的泛素化修饰在坏死性炎症中的作用和干预策略研究,2022/01-2026/12,100万元,在研,项目骨干
3、国家自然科学基金优青项目,82122056,肿瘤微环境,2022/01-2024/12,200万元,在研,项目负责人。
4、国家自然科学基金面上项目,82073153,甲基转移酶Suv39h1介导I型干扰素信号通路调控肿瘤免疫微环境的机制及功能研究,2021/01-2024/12,57万元,在研,项目负责人。
5、国家自然科学基金面上项目,31871398,磷酸化修饰调控SET1A活性及其在肿瘤中的机制及功能研究,2019/01-2022/12,60万元,结题,项目负责人。
6、上海市青年科技启明星计划,19QA1406700,SET1A在肿瘤免疫微环境中的调控机制研究,2019/04-2022/03,40万元,结题,项目负责人。
7、中国科协青年人才托举工程,2018QNRC001,2018/01-2020/12,45万元,结题,项目负责人。
8、上海市卫计委优秀青年人才培养计划,2017YQ068,肿瘤微环境调控YAP甲基化修饰促进肿瘤发生发展机制研究,2017/07-2020/06,30万元,结题,项目负责人。
9、国家自然科学基金青年项目,31501051,KLF4核糖基化和去乙酰化修饰差异在NSCLC中的功能和调控机制研究,2016/01-2018/12,22万元,结题,项目负责人。
10、同济大学青年优秀人才培养计划,2015KJ054,YAP甲基化修饰调控Hippo信号通路参与肿瘤发生的机制研究,2016/01-2017/12,2.5万元,结题,项目负责人。
11、上海市科委“科技创新行动计划”,小动物活体成像仪共享配套操作与应用技术研究,16142202600,2016/10-2018/09,10万元,结题,项目负责人。
1. Lan Fang(*), Yun Hao, Haihong Yu, Xuemei Gu, Qiao Peng, Huimin Zhuo, Yaxu, ZhiyuanLiu, Jia Wang, Yunfei Chen, Jiawen Zhang, Hongling Tian, Yaohui Gao, Renyuan Gao, Hongqi Teng, Zezhi Shan, Jiali Zhu, Zhiqiang Li, Yu’e Liu, Yiyi Zhang,Fei Yu, Zhang Lin, Yujun Hao, Xin Ge, Jian Yuan, Hong-Gang Hu, Yanlei Ma, Huan-Long Qin,Ping Wang(*).Methionine restriction promotes cGASactivation and chromatin untethering through demethylation to enhance antitumorimmunity, CancerCell, 12 June 2023, Pages 1118-1133.e12.
2. Yu'e Liu#, Yanjin Wang#, Yanrong Yang#, Linjun Weng, Qi Wu, Jin Zhang, Pengcheng Zhao, Lan Fang(*), Yufeng Shi(*), Ping Wang(*).Emerging phagocytosis checkpoints in cancer immunotherapy. Signal TransductTarget Ther, 2023 Mar 7;8(1):104
3. Jiawen Zhang#, Yunfei Chen#,Xianfei Chen, Wen Zhang, Linlin Zhao, Linjun Weng, Hongling Tian, Zhiqiang Wu,Xiao Tan, Xin Ge, Ping Wang(*), Lan Fang(*). DeubiquitinaseUSP35 restrains STING-mediated interferon signaling in ovarian cancer. Cell Death & Differentiation, 2021 Jan;28(1):139-155.
4. Lan Fang#, Hongqi Teng#, Yilin Wang#, Guanghong Liao#, Linjun Weng, Yaxu Li,Xinbo Wang, Jiali Jin, Chenchen Jiao, Lei Chen, Xiaoping Peng, Jiayu Chen, YongzhiYang, Houqin Fang, Dongyan Han, Cheng Li, Xueling Jin, Shihao Zhang, ZhongchenLiu, Min Liu, Qing Wei, Lujian Liao, Xin Ge, Bin Zhao, Dawang Zhou, Huan-LongQin, Jun Zhou, Ping Wang*. SET1A-Mediated Mono-Methylation at K342Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis. Cancer Cell, 2018 Jul 9;34(1):103-118.
5. Lan Fang#, Jun Zhang#, Hui Zhang#, Xiaoqin Yang, Xueling Jin, Ling Zhang,David G. Skalnik, Ying Jin, Jiwen Li, Yong Zhang, Xingxu Huang and Jiemin Wong*.H3K4 Methyltransferase Set1a Is A Key Oct4 CoactivactorEssential for Generation of Oct4 Positive Inner Cell Mass. Stem Cells, 2016 Mar;34(3):565-80.
6. Yuanhui Jia#, Pishun Li#, LanFang#, Haijun Zhu, Liangliang Xu, Hao Cheng, Junying Zhang, Fei Li, YanFeng, Yan Li, Jialun Li, Ruiping Wang, James X. Du, Jiwen Li, Taiping Chen,Hongbin Ji, Jackie Han, Wenqiang Yu, Qihan Wu, and Jiemin Wong*. NegativeRegulation of DNMT3A De Novo DNA Methylation by UHRF Family Proteins as aMechanism for Widespread DNA Hypomethylation in Cancer. Cell Discovery, 2016 Apr 12;2:16007.
7. Lan Fang#, Ling Zhang, Wei Wei, Xueling Jin, Ping Wang, Yufeng Tong, JiwenLi, James X. Du and Jiemin Wong*. A Methylation-Phosphorylation SwitchDetermines Sox2 Stability and Function in ES cell Maintenance orDifferentiation. Molecular Cell, 2014 Aug21;55(4):537-51.
8. Dai X, Jiang C, Jiang Q, Fang L, Yu H, Guo J, Yan P, Chi F,Zhang T, Inuzuka H, Asara JM, Wang P, Guo J, Wei W. AMPK-dependentphosphorylation of the GATOR2 component WDR24 suppresses glucose-mediatedmTORC1 activation. Nat Metab. 2023 Feb;5(2):265-276.
9. Jiang C, Dai X, He S, Zhou H, Fang L, Guo J, Liu S, Zhang T, Pan W, YuH, Fu T, Li D, Inuzuka H, Wang P, Xiao J, Wei W. Ring domains are essential forGATOR2-dependent mTORC1 activation. Mol Cell. 2023 Jan 5;83(1):74-89
10. Zhiqiang Wu#, Linjun Weng#, Tengbo Zhang#,Hongling Tian, Lan Fang, Hongqi Teng, Wen Zhang, Jing Gao, Yun Hao, YaxuLi, Hu Zhou & Ping Wang*. Identification of Glutaminyl Cyclaseisoenzyme isoQC as a regulator of SIRPα-CD47 axis. CellResearch, 2019, 29, 502–505.
11. Xinbo Wang#; Jiali Jin#; Fangning Wan#;Linlin Zhao#; Hongshang Chu; Cong Chen; Guanghong Liao; Jian Liu; Yue Yu;Hongqi Teng; Lan Fang; Cong Jiang; Weijuan Pan; Xin Xie; Jia Li; XiaolinLu; Xuejun Jiang; Xin Ge(*); Dingwei Ye(*); Ping Wang*, AMPKPromotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer CellStemness. Developmental Cell, 2019.1, (48):1~16.
12. Yunfei Chen*, Lufan Wang*, Jiali Jin, Yi Luan, Cong Chen, Yu Li,Hongshang Chu, Xinbo Wang, Guanghong Liao, Yue Yu, Hongqi Teng, Yanming Wang,Weijuan Pan, Lan Fang, Lujian Liao,Zhengfan Jiang, Xin Ge, Bin Li, Ping Wang*. p38 inhibition provides anti–DNA virus immunity byregulationof USP21 phosphorylation and STING activation. TheJournal of Experimental Medicine, 2017 Vol. 214 No. 4 991–1010.
13. Guang Shi*, Meng Wu*, LanFang, Fang Yu, Shimeng Cheng, Jiwen Li, James X. Du and Jiemin Wong*. PHD Finger Protein 2 (PHF2) RepressesRibosomal RNA Gene Transcription by Antagonizing PHD Finger Protein 8 (PHF8)and Recruiting Methyltransferase SUV39H1. J Biol Chem.,2014 Oct 24;289(43):29691-700.
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