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本人具有多学科交叉的教育和研究背景,长期从事微纳米界面的凝胶功能化设计以及物理-酶促生物学效应相关的研究。针对重大疾病高效诊疗的重大需求,仿生生物酶催化过程及其诱导的生物学效应,提出“外场调控酶催化反应”新思路,构建程序化可控激活的载酶凝胶材料平台,阐明生物催化反应进程的外场调控和逆转机制,应用于生命体代谢过程调控和疾病诊疗研究。共发表SCI论文38篇,SCI他引2000余次,其中近5年来以第一/通讯作者在Nat.Commun.,(2篇) Acc. Chem. Res., Adv. Mater., Angew.Chem. Int. Ed.(2篇), Adv. Funct. Mater., Nano Lett.,Sci. China Chem., Sci. China Mater.等期刊上发表SCI论文12篇;入选上海市晨光学者(2015),担任上海市超声医学工程学会青年委员会委员和《无机材料学报》青年编委;主持国家自然基金面上项目(2018-2021、2022-2025)2项、青年项目1项(2015-2017,结题)、国家重点研发计划合作课题(2022-2025)1项,授权中国发明专利3项。
1. 口腔口咽瘘管快速修复有机-无机杂化凝胶材料(2022YFC2403200)国家重点研发计划,2022.11-2025.10,75万,合作课题负责人
2. 有序隔室化多酶凝胶的仿生构建与催化诊疗研究(52173289)国家自然科学基金面上项目2022.1-2025.12,57万,主持
3. 糖尿病足皮肤感知与创面修复的新型智能微针贴片(ZD-11-202151)学科交叉联合攻关首批示范项目重点项目,2021.8-2022.7,60万,子课题负责人(ZD-11-202151)
4. ROS响应的功能有机-无机杂化纳米凝胶体系及其酶诱导肿瘤诊疗研究(51773155)国家自然科学基金面上项目2018.1-2021.12,58万,主持
5. “长江三角洲农药污染场地修复及安全利用关键技术与应用研究”(2018YFC1803100)国家重点研发计划高浓度农药污染场地高效快速氧化技术遴选与研发(04002430163)国家科技计划,起止时间2019.1-2024.12,经费30万,参与
6. 用于精氨酸消耗治疗/化疗的多功能介孔纳米氧化硅体系构建(15CG16)上海市“晨光计划”资助项目2016.01-2018.12,6万,主持
7. 用于响应性超声/增强磁共振成像引导高强度聚焦超声治疗的纳米杂化凝胶体系(51402215)国家自然科学基金青年基金2015.01-2017.12,25万,主持
1) Xingyue He, Qing Wu, Chen Hou, Min Hu, Qigang Wang*, Xia Wang*, ACompartmentalized Nanoreactor Formed by Interfacial Hydrogelation for CascadeEnzyme Catalytic Therapy, AngewandteChemie International Edition, 2023, e202218766.
2) Yue Liao, Xia Wang,* Hongdou Shen, Ziyang Tai, Qigang Wang, *Dynamic assembly and biocatalysis-selected gelation endowself-compartmentalized multienzyme superactivity, Science China Chemistryvolume 65, 1985–1993,2022.
3) Xing Qin, Chu Wu, Dechao Niu,* Limei Qin, Xia Wang,* Qigang Wang,*& Yongsheng Li,* Peroxisome inspired hybrid enzyme nanogels forchemodynamic and photodynamic therapy, NatureCommunications, 12, 5243, 2021.
4) Chu Wu, Limei Qin, Dechao Niu,* Xia Wang,* Qi Zhang, Yinghui Shang,Min Hu, Xiaoke Han, Saiji Shen, Xing Qin, Songyan Xi, Yongsheng Li,* QigangWang,* A Compartmental Silica Nanoreactor for Multienzyme-Regulated SuperactiveCatalytic Therapy, Advanced FunctionalMaterials 31, 2103531, 2021.
5) Xia Wang, Qigang Wang,* Enzyme-Laden Bioactive Hydrogel forBiocatalytic Monitoring and Regulation, Accounts of Chemical Research, 2021,54, 1274−1287.
6) Xianmeng Xia , Xia Wang,* Xiaoke Han , Meiyuan Qi , Ya Gao ,Jiangnan Liao , Xingyue He , Kai Pan , Qian Cheng, Qigang Wang,* Constructionof self-assembled nanogel as mulitenzyme mimics for bioresponsivetandem-catalysis imaging, Science ChinaMaterials, 64, 3079–3086 (2021).
7) Qing Wu, Zhigang He, Xia Wang,* Qi Zhang, Qingcong Wei, Sunqiang Ma,Cheng Ma, Jiyu Li,* Qigang Wang,* Cascade enzymes within self-assembled hybridnanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancertherapy, Nature Communications, 10,240, 2019.
8) Xia Wang, Shuangshuang Chen, Dongbei Wu, Qing Wu, QingcongWei, Bin He,* Qinghua Lu,* Qigang Wang,*Oxidoreductase-Initiated Radical Polymerizations to Design Hydrogels andMicro/Nanogels: Mechanism, Molding, and Applications, Advanced Materials, 1705668, 2018.
9) Xia Wang, Xiao Yu, Xiaoshan Wang, Meiyuan Qi, Jing Pan, andQigang Wang,* One step Nanosurface Self-assembly of D-peptides RendersBubble-Free Ultrasound Theranostics, NanoLetters, 19 (4), 2251-2258, 2019.
10) Xia, Wang#; Li, Qiao#; Xiao, Yu; Xiaoshan, Wang; Lixin,Jiang*; Qigang, Wang*; Controllable Formation of TernaryInorganic-Supramolecular-Polymeric Hydrogels by Amidation-Fueled Self-assemblyand Enzymatic Post-cross-linking for Ultrasound Theranostic, ACSBiomaterials-Science & Engineering, 2019, 5(11): 5888-5896.
11) Meiyuan Qi, Hui Pan, Hongdou Shen, Xianmeng Xia, ChuWu, Xiaoke Han, Xingyue He, Wei Tong, Xia Wang* and Qigang Wang*, Nanogel Multienzyme Mimics Synthesized by Biocatalytic ATRP and MetalCoordination for Bioresponsive Fluorescence Imaging, Angewandte Chemie International Edition, 2020, 59, 11748–11753.
12) Qi Zhang, Yanan Lv, Mingyu Liu, Xia Wang,* Yongli Mi* and QigangWang,* Nanoinitiator for enzymatic anaerobic polymerization and graftenhancement of gelatin–PAAM hydrogel, Journalof Materials Chemistry B, 6, 1402-1409, 2018.
13) Qiao Li, Gao Yawei, Wei Qingcong, Hu Wen, Wu Lei, Li Pei, Zhu Rongrong, WangXia,* Wang Qigang,* Laccase-mediated formation of mesoporous silicananoparticle based redox stimuli-responsive hybrid nanogels as amultifunctional nanotheranostic agent, Nanoscale,8(39), 17241-17249, 2016.
14) Xia Wang, Dechao Niu, Pei Li, Qing Wu, XiaowanBo, Boji Liu, Song Bao, Teng Su, Huixiong Xu,* and Qigang Wang,*Dual-Enzyme-Loaded Multifunctional Hybrid Nanogel System for PathologicalResponsive Ultrasound Imaging and T2-Weighted Magnetic Resonance Imaging, ACS Nano, 9(6), 5646–5656, 2015.
15) Xia Wang, Dechao Niu, Chen Hu, Pei Li,* Polyethyleneimine-BasedNanocarriers for Gene Delivery, CurrentPharmaceutical Design, 21(42), 6140-6156, 2015.
16) Xia Wang, Hangrong Chen*, Yu Chen, Ming Ma, Kun Zhang, FaqiLi, Yuanyi Zheng, Deping Zeng, Qi Wang and Jianlin Shi*, Perfluorohexane-encapsulatedmesoporous silica nanocapsules as enhancement agents for highly efficient highintensity focused ultrasound (HIFU), AdvancedMaterials, 6, 785-791, 2012.
17) Xia Wang, Dechao Niu, Qing Wu, Song Bao, TengSu, Xiaohang Liu, Shengjian Zhang, and Qigang Wang*. Iron oxide/manganese oxideco-loaded hybrid nanogels as pH-responsive magnetic resonance contrast agents. Biomaterials, 53: 349-357, 2015.
18) Xia Wang, Hangrong Chen*, Yuanyi Zheng, Ming Ma, Yu Chen, Kun Zhang, Deping Zen,Jianlin Shi*, Au-nanoparticle coated mesoporous silica nanocapsule-basedmultifunctional platform for ultrasound mediated imaging, cytoclasis and tumorablation, Biomaterials, 34, 2057-2068, 2013.
19) Xia Wang, HangrongChen*, Kun Zhang, Ming Ma, Faqi Li, Shuguang Zheng,Yu Chen, Lixin JiangHuixiong Xu and Jianlin Shi*, An intelligent nanotheranostic agent fortargeting, redox-responsive ultrasound imaging and the imaging-guided HIFUsynergistic therapy, Small,10(7):1403-1411, 2014.
20)Xia Wang, Wei Li* and JianlinShi*, Synthesis and phase evolution of LiNb0.6Ti0.5O3powder via a sol-gel method. Particuology,8, 463-467, 2010.
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