张杰：同济大学医学院副教授，同济大学新生院特聘本科生导师，中科院上海生命科学研究院博士后。美国华盛顿大学公共卫生学院生物统计学系访问学者，新加坡国立大学计算机学院计算生物学系访问学者。现任中国抗癌协会骨与软组织肿瘤热疗及生物信息专家委员会副主委，上海医学会临床流行病学与循证医学分会委员，上海医学会临床流行病学与循证医学专科分会临床研究方法学组副组长。Frontiers in Genetics(IF:4.599)杂志副主编，Frontiers in Bioengineering and Biotechnology(IF:5.890), Frontiers in Genetics(IF:4.599)和Frontiers in Plant Science(IF:5.753)杂志的审稿编辑及审稿人。

合作单位：同济大学附属同济医院、海军医科大学附属长海医院等。

1、上海市卫生健康委员会卫生行业临床研究专项，miR-122通过IGF1R/PI3K/AKT信号通路在PM2.5诱导的肺损伤中的调控机制，2020.1-2022.12，主持；

2、国家重点研发计划项目“农村厕所粪便高效资源化利用关键技术与示范”，2018.12-2022.12，项目骨干；

3、国家自然基金青年项目，Ube3a介导的蛋白质泛素化在心肌肥大发生过程中的作用研究，2016.1-2018.12，主持；

4、同济大学医学院扬帆计划项目，Ube3a在心肌肥大中的作用及分子机制研究，2015.05-2015.12，主持；

5、上海市气象与健康重点实验室开放项目，PM2.5与心肌肥厚的关系及其分子机制的研究，2014/09-2015/12，主持；

6、上海市卫生局青年科研项目，20124y166，Ube3a在心肌肥大中的作用及分子机制研究，2013/01-2014/12，结题，主持；  

7、国家自然基金面上项目，肾上腺素能受体SNPs及PWV、CBP对射血分数保留心衰的发病及药物敏感性的影响，2015/01-2018/12，第二负责人；

8、同济大学第九期实验教改项目，计量资料统计推断相关方法在社区人群心血管健康项目研究中的应用， 2013/10-2015/10，主持；

9、同济大学优秀青年培养计划项目，1500219046，基于信息学及实验方法的内质网应激条件下心衰相关基因的筛选与证实，2011/11-2013/10，结题，主持。

1、上海市卫生健康委员会卫生行业临床研究专项，miR-122通过IGF1R/PI3K/AKT信号通路在PM2.5诱导的肺损伤中的调控机制，2020.1-2022.12，主持；

2、国家重点研发计划项目“农村厕所粪便高效资源化利用关键技术与示范”，2018.12-2022.12，项目骨干；

3、国家自然基金青年项目，Ube3a介导的蛋白质泛素化在心肌肥大发生过程中的作用研究，2016.1-2018.12，主持；

4、同济大学医学院扬帆计划项目，Ube3a在心肌肥大中的作用及分子机制研究，2015.05-2015.12，主持；

5、上海市气象与健康重点实验室开放项目，PM2.5与心肌肥厚的关系及其分子机制的研究，2014/09-2015/12，主持；

6、上海市卫生局青年科研项目，20124y166，Ube3a在心肌肥大中的作用及分子机制研究，2013/01-2014/12，结题，主持；  

7、国家自然基金面上项目，肾上腺素能受体SNPs及PWV、CBP对射血分数保留心衰的发病及药物敏感性的影响，2015/01-2018/12，第二负责人；

8、同济大学第九期实验教改项目，计量资料统计推断相关方法在社区人群心血管健康项目研究中的应用， 2013/10-2015/10，主持；

9、同济大学优秀青年培养计划项目，1500219046，基于信息学及实验方法的内质网应激条件下心衰相关基因的筛选与证实，2011/11-2013/10，结题，主持。

主要针对心脑血管疾病、癌症等开展了统计学分析及数据挖掘研究，主持和承担国家自然科学基金及上海市等省部级以上项目5项。以第一作者或通讯作者在Aging un US, Front.Cell.Dev.Biol, Journal of cellular and molecular medicine, Cancer medicine等杂志发表SCI收录论文30余篇，累计影响因子180余分，中文核心期刊3篇。

参编并出版书籍

1. Jie Zhang*, Genomic Approach Asthma, chapter 15: Biostatistics, data mining and computational modeling, Springer Publishing, 2018.

2. 参编《流行病学双语教材》同济大学出版社。(Bilingual Textbook of Epidemiology)

近年来以通讯作者或第一作者发表的部分论著：

1.        Lin Sun, Jie Zhang, Wei Li, Jianhua Sheng, ShifuXiao, Neutrophil activation may trigger tau burden contributing to cognitiveprogression of chronic sleep disturbance in non-dementia elderly, BMC Medicine,2023, 21(1):205. (并列第一, IF=11.15)

2.       Jiawen Wu, JialeYan, Zheng Hua, Jingyi Jia, Zhitong Zhou, Junfang Zhang, Jue Li, Jie Zhang, Identificationof molecular signatures in acute myocardial infarction based on integrativeanalysis of proteomics and transcriptomics, Genomics, 2023, 115(5):110701. (通讯作者, IF=4.40)

3.       Wenwen Wang,Wenhuizi Sun, Han Xu, Yao Liu, Chenlu Wei, Siqiao Wang, Shuyuan Xian, PenghuiYan, Jiajun Zhang, Hongjun Guo, Hengwei Qin, Jie Lian, Xiangyu Han, JiaqiZhang, Ruixia Guo, Jie Zhang,Zongqiang Huang, Bibliometric analysis and mini-review of global research onpyroptosis in the field of cancer, Apoptosis, 2023. (并列通讯作者, IF=7.04)

4.       Runzhi Huang,Yuntao Yao, Xirui Tong, Lei Wang, Weijin Qian, Jianyu Lu, Wei Zhang, Yifan Liu,Siqiao Wang, Shuyuan Xian, Yushu Zhu, Jie Huang, Xinya Guo, Minyi Gu, Hanlin Lv,Wenshuai Bi, Chenwei Meng, Zhengyan Chang, JieZhang, Dayuan Xu, Shizhao Ji, Tracing the evolving dynamics and researchhotspots of microbiota and immune microenvironment from the past to the new era.Microbiology Spectrum. 2023 e0013523. (并列通讯作者, IF=3.70)

5.       Runzhi Huang,Bingnan Lu, Man Li, Zhouxiao Li, Penghui Yan, Huabin Yin, Jiwen Zhu, ShuyuanXian, Yannan Qiao, Xinkun Zhang, Ruoyi Lin, Siqiao Wang, Chenlu Wei, YangkunGuo, Jie Zhang, Tong Meng, ZongqiangHuang, BMC Medical Genomics, 2023. (并列通讯作者, IF=2.70,accepted)

6.       Yifan Liu,Mingxiang Fan, Shuyuan Xian, Peng Hu, Mengyi Zhang, Xinkun Zhang, Hao Zhang,Junfang Zhang, Lingli Dai, Mingyue Lin, Wangli Mei, Dan Huang, Runzhi Huang, Jie Zhang, Zongqiang Huang, RBP7regulated by EBF1 affects Th2 cells and oocyte meiosis pathway in the bonemetastasis of bladder urothelial carcinoma, FBL, 2023, ;28(8):189. (通讯作者, IF=3.115)

7.       Wenhuizi Sun,Runzhi Huang, Zhenyu Li, Yaru Zhu, Yan Bai, Siyu Wu, Jingshuai Wang, Yan Xiao,Shuyuan Xian, Xiaowen Tong, Jie Zhang,Yi Guo, Yiqin Ouyang, Alternative ANKHD1 transcript promotes proliferation andinhibits migration in uterine corpus endometrial carcinoma, NPJ GenomicMedicine,2022, 29;7(1):56. (通讯作者, IF:6.083)

8.       Jun Liu, JingyiJia, Siqiao Wang, Junfang Zhang, Shuyuan Xian, Zixuan Zheng, Lin Deng, YonghongFeng, Yuan Zhang, Jie Zhang,Prognostic ability of enhancer RNAs in metastasis of Non-2 small cell lungcancer, Molecules, 2022. (通讯作者, IF:4.411)

9.       Zhitong, Zhou,Runzhi,Huang,Guoyang, Zhang,Meiqiong, Gong,Shuyua,n Xian,Huabin Yin, Tong Meng,Xiaonan Wang, Yue Wang, Wenfang Chen, Chongyou Zhang, Erbin Du, Min Lin, XinLiu, Qing Lin, Shizhao Ji, Hongbin Wu, Zongqiang Huang, Jie Zhang, Nomograms for predicting medical students’ perceptionsof the learning environment: multicenter evidence from medical schools inChina, Frontiers in Public Health. 2022. (并列通讯作者, IF:6.461)

10.     ZhiquanHao, Siqiao Wang, Zixuan Zheng, Jiehan Li, Wanting Fu, Donglin Han, YinrouHuang, Qing Lin, Shuyuan Xian, Penghui Yan, Man Li, Ruoyi Lin, Tong Meng, Jie Zhang, Zongqiang Huang, PrognosticBone Metastasis-Associated Immune-Related Genes Regulated by TranscriptionFactors in Mesothelioma, BioMed Research International, 2022. (并列通讯作者, IF:3.411)

11.     XiaoliLuo, Zhitong Zhou, Jiawen Wu, Lijuan Zhang,Jie Zhang, Jue Li, Integrated RNA- and miRNA-Sequencing analysis identifiesmolecular basis for stress-induced heart injury in mouse models, InternationalJournal of Cardiology, 2022. (并列通讯作者, IF:4.164)

12.     JieZhang, Gareth J. William3 , Guanghua Wang, Jingjing Chen , Mengyu Zhang,Wenchong Du, Jing Zhu, Jun Zhang, Jing Hua, Early term birth and itsassociation with universal two-child policy：anational cross-sectional study in China, BMJ Open, 2021. (第一作者, IF:3.006)

13.     RunzhiHuang,Siqiao Wang,Rui Zhu,Shuyuan Xian,Zongqiang Huang,Liming Cheng,Jie Zhang, Identification of Key eRNAsfor Spinal Cord Injury by Integrated Multinomial Bioinformatics Analysis,Frontiers in cell and development.9, 2021. doi: 10.3389/fcell.2021.728242. (通讯作者, IF:6.684)

14.     RunzhiHuang, Jiayao Zhang, Shuyuan Xian, Jingyi Jia, Dianwen Song, Penghui Yan, HuabinYin, Peng Hu, Xiaolong Zhu, Tong Meng, JieZhang, Identification Of Prognostic And Bone Metastatic AlternativeSplicing Signatures In Bladder Cancer, Bioengineered, 2021,12:1,5289-5304. (通讯作者, IF:3.269)

15.     HuangRunzhi, Zheng Zixuan, Liu Sijia, Ya, Penghui, Song Dianwen, Yin Huabin, Hu Peng,Zhu Xiaolong, Chang Zhengyan, Liu Yihan, Zhuang Juanwei, Meng Tong, Huang,Zongqiang, Zhang Jie, Identificationof prognostic and bone-metastasis related alternative splicing signatures inmesothelioma, Cancer Medicine, 2021, 10(12), DOI:10.1002/cam4.3977.  (通讯作者, IF:4.452)

16.     RunzhiHuang, Zhenyu Li, Xiaolong Zhu, Penghui Yan, Dianwen Song, Huabin Yin, Peng Hu,Ruoyi Lin, Shengyu Wu, Tong Meng, Jie Zhang, Zongqiang Huang, Collagen Type IIIAlpha 1 chain regulated by GATA-Binding Protein 6 affects Type II IFN responseand propanoate metabolism in the recurrence of lower grade glioma, Journal ofCellular and Molecular Medicine, 2020. 24(18):10803-10815 DOI: 10.1111/jcmm.15705. (并列通讯作者, IF:5.310)

17.     RunzhiHuang, Juanru Guo, Penghui Yan, Suna Zhai, Peng Hu, Xiaolong Zhu, Jiayao Zhang,Yannan Qiao, Yu Zhang, Hui Liu1, Ling Huang, Jie Zhang, Daoke Yang andZongqiang Huang, The Construction of Bone Metastasis-Specific Prognostic Modeland Co-expressed Network of Alternative Splicing in Breast Cancer,Front.Cell.Dev.Biol. 2020, doi.org/10.3389/fcell.2020.00790. (并列通讯作者, IF:5.292)

18.     ZhengyanChang, Guo Ji, Runzhi Huang, Hong Chen, Yaohui Gao, Weifeng Wang, Xuechen Sun, Jie Zhang, Jiayi Zheng, and Qing Wei. PIWI-interactingRNAs piR-13643 and piR-21238 are promising diagnostic biomarkers of thyroidcancer，Agingin US, 2020 May 19;12(10):9292-9310. (并列通讯作者, IF:5.682)

19.     WeiLi, Jie Zhang, Shifu Xiao, Lin Sun, Characteristicsof health worker fatality in China during the outbreak of COVID-19 infection，JOURNAL OF INFECTION. 2020, (并列第一作者, IF: 38.637，研究型letter)

20.     JieZhang, Jiaqi Wang, Han Yu, Guanghua Wang, Junfang Zhang, Rui Zhu, Xuebo Liu,and Jue Li, Comparison between atorvastatin and rosuvastatin on secondarypercutaneous coronary intervention rate and the risk factors in patietnts withcoronary heart disease. Current drug metabolisms, 2020, 21, 818-828.  (第一作者, IF:3.731)

21.     RunzhiHuang, Tong Meng, Rui Zhu, Lijuan Zhao, Dianwen Song, Huabin Yin, ZongqiangHuang, Liming Cheng and Jie Zhang,The Integrated Transcriptome Bioinformatics Analysis Identifies Key Genes andCellular Components for Spinal Cord Injury-related Neuropathic Pain，FrontBioeng Biotechnol. 2020, 8(101). (通讯作者, IF:5.890)

22.     Runzhi,Huang, Zhenyu Li, Chen Li, Guanghua Wang, Penghui Yan, Li Peng, Jiaqi Wang,Xiaolong Zhu, Peng Hu, Junfang Zhang, Zhengyan Chang, Zongqiang Huang, limingCheng, Jie Zhang, Germ Cell-SpecificGene 1-Like Protein Regulated by Splicing Factor CUGBP Elav-Like Family Member5 and Primary Bile Acid Biosynthesis are Prognostic in Glioblastoma Multiforme,Frontier in Genetics,10, 1380, 2020. (通讯作者，IF:4.599)

23.     RunzhiHuang, Ziqi Liu, Tingli Tian, Dianwen Song, Penghui Yan, Huabin Yin, Peng Hu,Xiaolong Zhu, Yihan Liu, Zhenyu Li, Tong Meng, Jie Zhang, Zongqiang Huang, Theconstruction and analysis of tumor-infiltrating immune cells and ceRNA networksin metastatic adrenal cortical carcinoma, Bioscience Reports, 2020, 40,BSR20200049. (通讯作者，IF: 3.840)

24.     RunzhiHuang, Jiawen Wu, Zixuan Zheng, Guanghua Wang, Dianwen Song, Penghui Yan,Huabin Yin, Peng Hu, Xiaolong Zhu, Haiyun Wang6, Qi Lv, Tong Meng, ZongqiangHuang, Jie Zhang，Theconstruction and analysis of ceRNA network and Patterns of immune infiltrationin Mesothelioma with bone metastasis, Front Bioeng Biotechnol. 2019 Oct 18; 7:257.doi: 10.3389/fbioe.2019.00257. eCollection 2019. (通讯作者, , IF:5.890)

25.     陈静静，王光花，彭丽，许炜晨，徐润平，张杰，中国南北方地区阴道试产孕妇不良母婴结局分析，同济大学学报（医学版），2019， 40（4），501-506. （通讯作者，核心期刊）

26.    Tong Meng,Runzhi Huang, Zhiwei Zeng, Zongqiang Huang, Huabin Yin, ChenChen Jiao, PenghuiYan, Peng Hu, Xiaolong Zhu, Zhenyu Li, Dianwen Song, Jie Zhang, Liming Cheng, Identificationof prognostic and metastatic alternative splicing signatures in kidney renalclear cell carcinoma, Frontiers in Bioengineering and Biotechnology, 7, 270, 2019. (共同通讯作者, IF:5.890)

27.    Runzhi Huang,Zhiwei Zeng, Guangyu Li,Dianwen Song, Penghui Yan, Huabin Yin, Peng Hu,XiaolongZhu, Ruizhi Chang, Xu Zhang, Jie Zhang,Tong Meng, Zongqiang Huang, The construction and comprehensive analysis ofceRNA networks and tumorinfiltrating immune cells in bone metastatic melanoma,Frontier in Genetics, 10，828，2019.(共同通讯作者, IF:4.599)

28.     Lin Sun, Hua Xu, Jie Zhang*, Wei Li, Jing Nie, QiQiu, Yuanyuan Liu, Yuan Fang,Zhi Yang, Xia Li and Shifu Xiao, Alcohol Consumption and Subclinical Findingson Cognitive Function, Biochemical Indexes, and Cortical Anatomy in CognitivelyNormal Aging Han Chinese Population, Frontiers in Aging Neuroscience,10:182,2018. (并列第一作者, IF:5.75)

29.     Yongzhao Zhao, Huixian Wang, Yan Shi, Shangli Cai,Tongwei Wu, Guangyue Yan, Sijin Cheng, Kang Cui, Ying Xi, Xiaolong Qi, Jie Zhang*, and Wang Ma. Comparative effectiveness ofcombined therapy inhibiting EGFR and VEGF pathways in patients with advancednon-small-cell lung cancer: a meta-analysis of 16 phase II/III randomizedtrials. Oncotarget, 8(4): 7014-7024.2017. (通讯作者, IF:5.168)

30.     Jie Zhang*,Rui Song, Luying Peng, Jue Li. Integration of Cardiomyopathy Microarrayprofiles and the Potential Role of Ube3a in apoptosis, Molecular MedicineReports9: 621-625, 2014. （第一&通讯作者, IF:2.952）

31.     LiY, Shen D, Tang X, Li X, Wo D, Yan H, Song R, Feng J, Li P, Zhang J*, Li J. Chlorogenic acidprevents isoproterenol-induced hypertrophy in neonatal rat myocytes, ToxicolLett. 226(3):257-263,2014. （通讯作者, IF:4.372）

32.     R.Song, J. Zhang*, L. Zhang, G. Wang,D. Wo, J. Feng, X. Li and J. Li, H2O2 Induces Myocardial Hypertrophy in H9c2Cells: A Potential Role of Ube3a. Cardiovascular toxicology, 2014, DOI:10.1007/s12012-014-9264-0. (共同第一&通讯作者,IF:3.231)

33.     Zhang J,Wang G, Feng J, Zhang L, Li J. Identifying ion channel genes related tocardiomyopathy using a novel decision forest strategy. Mol Biosyst.10(9):2407-14, 2014. （第一&通讯作者,IF:2.759）

34.     Jie Zhang*,Li Li, Luying Peng, Yingxian Sun, Jue Li. An efficient weighted graph strategyto identify relevant genes for the control of the embryonic stem celldifferentiation. Plos one, Volume 8, Issue 4, e62716, 2013.（第一&通讯作者,IF: 3.534）