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魏珂,同济大学生命科学与技术学院教授,附属东方医院再生医学研究所特聘研究员。本科毕业于清华大学生物科学与技术系,于美国加利福尼亚大学洛杉矶分校分子细胞综合生理专业获得博士学位,后在美国桑福德伯纳姆普利贝司医学研究所进行博士后科学研究。入选国家海外高层次人才青年项目,主持并参与多项国家自然科学基金项目及科技部重点研发项目。主要研究方向为心脏发育与再生,通过高内涵筛选发现了影响心肌细胞增殖的旁分泌分子,miRNA以及小分子抑制剂;发现了心肌细胞成熟过程的新颖分子机制,为开发创新性针对心肌细胞再生的药物提供了新的方向。发表SCI论文30余篇,其中以第一作者及通讯作者发表包括Nature, Circulation, Nature Communications, Cardiovasc Res, Protein & Cell在内的论文16篇,并获得两项美国专利授权。
Yansong Tang#, Mengying Feng#, Yang Su, Teng Ma, Hongjie Zhang, Hongchun Wu, Xiaoyu Wang, Shuyue Shi, Ying Zhang, Yawei Xu, Shijun Hu, Ke Wei*, Dachun Xu* “Jmjd4 facilitates Pkm2 degradation in cardiomyocytes and is protective against dilated cardiomyopathy” (2023) Circulation (https://doi.org/10.1161/CIRCULATIONAHA.123.064121) (# Co-first authors; * corresponding authors)
Shuangshuang Zhao#, Qiuping Xu#, Yanqin Cui#, Su Yao, Sihui Jin, Qian Zhang, Zeyu Wen, Haihua Ruan, Xin Liang, Yanjie Chao, Sitang Gong, Philippe Sansonetti, Ke Wei*, Hong Tang*, Yaming Jiu* “Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection” (2023) Nature Communications 14(1), 478 (# Co-first authors; *corresponding authors)
Jing Zhang#, Zhaohui Ouyang#, Limei Xia, Qi Wang, Feng Zheng, Kun Xu, Yuexian Xing, Ke Wei*, Shaolin Shi*, Chaojun Li*, Jingping Yang* “Dynamic chromatin landscape encodes programs for perinatal transition of cardiomyocytes” (2023) Cell Death Discovery 9(1), 11 (# Co-first authors; * corresponding authors)
王皓存,欧阳兆惠,魏珂* “心肌细胞的成熟及其转录调控” 中国细胞生物学学报 (2022) 44:8 1473–1483 (*通讯作者)
Mengying Feng, Yansong Tang, Su Yao, Hongjie Zhang, Xu Dachun, Ke Wei* “PLK inhibitors identified by high content phenotypic screening promote maturation of human PSC-derived cardiomyocytes” (2022) Biochemical and Biophysical Research Communications 620 (2022) 113-120 (* corresponding author)
Hongjie Zhang#, Lijuan Pei#, Zhaohui Ouyang, Haocun Wang, Xin Chen, Kai Jiang, Shiqi Huang, Rui Jiang, Yaozu Xiang, Ke Wei* “AP-1 activation mediates postnatal cardiomyocyte maturation” (2022) Cardiovascular Research 119(2), 536-550 (# Co-first authors; * corresponding author)
Lijuan Pei, Hongjie Zhang, Meihui Zhang, Yixuan Wang*, Ke Wei* “Rcor2 Is Required for Somatic Differentiation and Represses Germline Cell Fate” (2022) Stem Cells International 2022:5283615 (* corresponding author)
Jianyong Du#, Lixia Zheng#, Peng Gao, Hang Yang, Wan-Jie Yang, Fusheng Guo, Ruqi Liang, Mengying Feng, Zihao Wang, Zongwang Zhang, Linlu Bai, Ye Bu, Shijia Xing, Wen Zheng, Xuelian Wang, Li Quan, Xinli Hu, Haosen Wu, Zhixing Chen, Liangyi Chen, Ke Wei, Zhe Zhang, Xiaojun Zhu, Xiaolin Zhang, Qiang Tu, Shi-Min Zhao*, Xiaoguang Lei*, Jing-Wei Xiong* “A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration” (2022) Cell Stem Cell 29 (4), 545-558. e13 (# Co-first authors; * corresponding authors)
Zhaohui Ouyang, Ke Wei* “miRNA in cardiac development and regeneration” (2021) Cell Regeneration 10 (1):1-21 (* corresponding author)
Zhaohui Ouyang#, Shuangshuang Zhao#, Su Yao#, Jing Wang, Yanqin Cui, Ke Wei*, Yaming Jiu* “Multifaceted Function of Myosin-18, an Unconventional Class of the Myosin Superfamily” (2021) Frontiers in Cell and Developmental Biology 9;9:632445. (# Co-first authors; * corresponding authors)
Lei Gao#, Hongjie Zhang#, Jingyi Cui, Lijuan Pei, Shiqi Huang, Yaning Mao, Zhongmin Liu*, Ke Wei*, Hongming Zhu* “Single-cell transcriptomics of cardiac progenitors reveals functional subpopulations and their cooperative crosstalk in cardiac repair” (2021) Protein & Cell 12(2):152-157 (# Co-first authors; * corresponding authors)
Weina Zhang, Yu Chen, Jiaqing Yang, Jing Zhang, Jiayu Yu, Mengting Wang, Xiaodong Zhao, Ke Wei, Xiaoping Wan, Xiaojun Xu, Ying Jiang, Jiayu Chen, Shaorong Gao, Zhiyong Mao* “A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing” (2020) Elife e56008
Ying Tao, Hongjie Zhang, Shiqi Huang, Lijuan Pei, Mengying Feng, Xiaodong Zhao, Zhaohui Ouyang, Su Yao, Rui Jiang, Ke Wei* “miR-199a-3p Promotes Cardiomyocyte Proliferation by Inhibiting Cd151 Expression” (2019) Biochemical and Biophysical Research Communications 516(1): 28-36 (* corresponding author)
Ke Wei*, Vahid Serpooshan*, Cecilia Hurtado, Marta Diez-
Cuñado, Mingming Zhao, Sonomi Maruyama, Wenhong Zhu, Giovanni Fajardo, Michela Noseda, Kazuto Nakamura, Xueying Tian, Qiaozhen Liu, Andrew Wang, Yuka Matsuura, Paul Bushway, Wenqing Cai, Alex Savchenko, Morteza Mahmoudi, Michael D. Schneider, Maurice J. B. van den Hoff, Manish J. Butte, Phillip C. Yang, Kenneth Walsh, Bin Zhou, Daniel Bernstein, Mark Mercola & Pilar Ruiz-Lozano “Epicardial FSTL1 Reconstitution Regenerates the Adult Mammalian Heart” (2015) Nature 525: 479-485 (* Co-first authors)
Marta Diez-Cuñado, Ke Wei, Paul J Bushway, Mano R Maurya, Ranjan Perera, Shankar Subramaniam, Pilar Ruiz-Lozano, Mark Mercola “miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway” (2018) Cell Reports 23/7 2168-2174
Rosana Crespo, Ke Wei, Boris Rodenak-kladniew, Mark Mercola, Pilar Ruiz-Lozano, Cecilia Hurtado “Effect of geraniol on rat cardiomyocytes and its potential use as a cardioprotective natural compound” (2017) Life Sciences 172, 8-12
Ke Wei*, Ramon Díaz-Trelles*, Qiaozhen Liu, Marta Diez-Cuñado, Maria-Cecilia Scimia, Wenqing Cai, Junko Sawada, Masanobu Komatsu, Joseph J. Boyle, Bin Zhou, Pilar Ruiz-Lozano, and Mark Mercola “Developmental origin of age-related coronary artery disease” (2015) Cardiovascular Research 107 (2): 287-294 (* Co-first authors)
Vahid Serpooshan, Morteza Mahmoudi, Mingming Zhao, Ke Wei, Senthilkumar Sivanesan, Khatereh Motamedchaboki, Andrey V. Malkovskiy, Andrew.B. Gladstone, Jeffrey Cohen, Phillip C. Yang, Jayakumar Rajadas, Daniel Bernstein, Y. Joseph Woo, Pilar Ruiz-Lozano “Protein corona influences cell-biomaterial interactions in nanostructured tissue engineering scaffolds.” (2015) Advanced Functional Materials 25 (28): 4379-4389
Vahid Serpooshan, Mingming Zhao, Scott A Metzler, Ke Wei, Parisha B Shah, Andrew Wang, Morteza Mahmoudi, Andrey V Malkovskiy, Jayakumar Rajadas, Manish J Butte, Daniel Bernstein, Pilar Ruiz-Lozano (2014) “Use of bio-mimetic three-dimensional technology in therapeutics for heart disease” Bioengineered 5:3, 193-197
Wenqing Cai, Sonia Albini, Ke Wei, Erik Willems, Rosa M Guzzo, Masanao Tsuda, Lorenzo Giordani, Sean Spiering, Leo Kurian, Gene W Yeo, Pier Lorenzo Puri, Mark Mercola (2013) “Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment” Genes & Development 27(21):2332-44
Vahid Serpooshan, Mingming Zhao, Scott A Metzler, Ke Wei, Parisha B Shah, Andrew Wang, Morteza Mahmoudi, Andrey V Malkovskiy, Jayakumar Rajadas, Manish J Butte, Daniel Bernstein, Pilar Ruiz-Lozano (2013) “The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction” Biomaterials 34(36):9048-55
Wenqing Cai, Rosa M. Guzzo, Ke Wei, Erik Willems, Herman Davidovics and Mark Mercola (2012) “A Nodal to TGFβ Cascade Exerts Biphasic Control Over Cardiopoiesis” Circulation Research 111: 876-881
Maria Cecilia Scimia, Cecilia Hurtado, Saugata Ray, Scott Metzler, Ke Wei, Jianming Wang, Chris E. Woods, Nicole H. Purcell, Daniele Catalucci, Takeshi Akasaka, Orlando F. Bueno, George P. Vlasuk, Perla Kaliman, Rolf Bodmer, Layton H. Smith, Euan Ashley, Mark Mercola, Joan Heller Brown & Pilar Ruiz-Lozano (2012) “APJ acts as a dual receptor in cardiac hypertrophy”. Nature 488: 394–398
Roberta Noberini, Sayantan Mitra, Ombretta Salvucci, Fatima Valencia, Srinivas Duggineni, Natalie Prigozhina, Ke Wei, Giovanna Tosato, Ziwei Huang, and Elena B. Pasquale (2011) “PEGylation Potentiates the Effectiveness of an Antagonistic Peptide That Targets the EphB4 Receptor with Nanomolar Affinity” Plos One 6(12): e28611
Natalie L. Prigozhina, Andrew Heisel, Ke Wei, Roberta Noberini, Edward A. Hunter, Diego Calzolari, Jordan R. Seldeen, Elena B. Pasquale, Pilar Ruiz-Lozano, Mark Mercola and Jeffrey H. Price (2011) “Characterization of a novel angiogenic model based on stable, fluorescently labeled endothelial cell lines amenable to scale-up for high content screening” Biology of the Cell 103(10): 467-81
Minqi Hao, Kevan Akrami, Ke Wei, Carlos De Diego, Nam Che, Jeong-Hee Ku, James Tidball, Michael C. Graves, Perry B. Shieh, Fabian Chen (2008) “Muscleblind-like 2 (Mbnl2) -deficient mice as a model for myotonic dystrophy” Developmental Dynamics 237(2): 403-10.
Ke Wei, Jiyuan Chen, Kevan Akrami, Gary C. Galbraith, Ivan A. Lopez, and Fabian Chen (2007) “Neural Crest Cell Deficiency of c-myc Causes Skull and Hearing Defects” Genesis 45(6): 382-390
Ke Wei, Jiyuan Chen, Kevan Akrami, and Fabian Chen (2007) “Generation of mice deficient for Lbx2, a gene expressed in the urogenital system, nervous system and Pax3 dependent tissues” Genesis 45(6): 361-368
Ke Wei, Nam Che, and Fabian Chen. (2007). “Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression” Developmental Dynamics 236(2): 416-425.
Xiao-Nan Dong, Ke Wei, Zu-Qiang Liu, and Ying-Hua Chen (2002). “Candidate peptide vaccine induced protection against classical swine fever virus” Vaccine 21(3-4): 167-173.
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