承担国家级人才项目1项

主持国家国家级项目5项

作为组长和骨干参与国家重点研发项目各1项

1. 原始生殖细胞及早期胚胎发育的调控机制

2. 体细胞重编程（克隆及诱导多能干细胞）的重塑机制

3. 人胎盘发育、母胎互作及妊娠相关疾病研究

4. 基于CRISPR/Cas9基因编辑技术的疾病模型构建与研究

1. 2020年度国家自然科学奖二等奖

2. 2022年度北京市自然科学奖一等奖

3. 2019年度教育部自然科学奖一等奖

4. 2023年度上海市五四奖章集体

5. 2022年“全国高校黄大年式教师团队”成员

6. 2022年同济大学“学生心目中的好导师”

7. 2022年同济大学“青年五四奖章”

8. 2020年同济大学育才教育奖励金优秀教师奖

1. Fang J#, Gao Y#, Kang Y#, Li Y, Chen Q, Chen J*, Zhang P*.Generation and characterization of a pluripotent stem cell line CIPi005-A derived from a female patient carrying non-canonical splice site c.827 + 1G > A in WDR45. Stem Cell Res. 2025 Apr;84:103686. doi: 10.1016/j.scr.2025.103686IF: 0.8 Q4 B4. Epub 2025 Feb 15.

2. Gao R#*, Yang G#, Wang M#, Xiao J#, Yi S, Huang Y, Guo Z, Kang Y, Fu Q, Wang M, Xu B, Shen S, Zhu Q, Liu M, Wang L, Cui X, Yi S, Kou X, Zhao Y, Gu L, Wang H, Gao S*, Jiang C*, Chen J*. Defining a TFAP2C-centered transcription factor network during murine peri-implantation. Development Cell. 2024 Apr 1:S1534-5807(24)00185-0. doi: 10.1016/j.devcel.2024.03.015IF: 10.7 Q1 B1.

3. Wang M#, Wang L#, Huang Y#, Qiao Z, Yi S, Zhang W, Wang J, Yang G, Cui X, Kou X, Zhao Y, Wang H, Jiang C*, Gao S*, Chen J*. Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects. SCIENCE CHINA Life Sciences. 2024 Oct;67(10):2132-2148. doi: 10.1007/s11427-024-2631-xIF: 8.0 Q1 B2

4. Shen S#, Wang M#, Li X#, Wang B#, Hong W#, Li W, Xu B, Guo Z, Han R, Yi S, Wu Z, He X, Wang L, Zhu Q, Yang G, Wang H, Deng Q, Chen J*（lead contact）, Gao S*, Jiang C*, Gao R*. The gonadal niche safeguards human fetal germline cell development following maternal SARS-CoV-2 infection. Cell Reports Medicine. 2024 May 21;5(5):101515. doi: 10.1016/j.xcrm.2024.101515IF: 11.7 Q1 B1.

5. Wang L#, Yi S#, Cui X#, Guo Z, Wang M, Kou X, Zhao Y, Wang H, Jiang C, Gao S*, Yang G*, Chen J*, Gao R*. Chromatin landscape instructs precise transcription factor regulome during embryonic lineage specification. Cell Reports. 2024 Apr 20;43(5):114136. doi: 10.1016/j.celrep.2024.114136IF: 7.5 Q1 B1.

6. Yi S#, Wang L#, Wang M#, Hong W#, Xu B#, He X, Yang M, Wu Z, Wang B, Yang G, Shen S, Cui X, Wang R, Wang K, Wang H, Li X*, Gao S*, Jiang C*, Chen J*. Effect of SARS-CoV-2 infection in early pregnancy on placental development. SCIENCE CHINA Life Sciences. 2024 Mar;67(3):622-625. doi: 10.1007/s11427-023-2437-xIF: 8.0 Q1 B2.

7. Kang Y#, Liang S*, Gao S*, Chen J*. Generation of a hiPSC line (TONGJIi001-A) from a 46,XX,ins(1;15)(p13.3;q22.31q26.1),inv(2)(p22.1p16.3),t(2;14)(q34;q12) infertility patient. Stem Cell Research. 2024 Dec:81:103561. doi: 10.1016/j.scr.2024.103561IF: 0.8 Q4 B4

8. Gao R#, Zeng S#, Yang D#, Li X#, Liu W, Gao Y, Bai D, Zhang L, Chen C, Kang Y, Wang B, Hong W, Wang M, Yin J, Wang H, Deng Q, Gao S*, Zhang Y*, Chen J*. Resetting histone modifications during human prenatal germline development. Cell Discovery. 2023 Feb 3;9(1):14. doi: 10.1038/s41421-023-00519-1IF: 13.0 Q1 B1.

9. Wang M#, Zhao K#, Liu M#, Wang M, Qiao Z, Yi S, Jiang Y, Kou X, Zhao Y, Yin J, Li T, Wang H, Jiang C*, Gao S*, Chen J*. BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding. Protein Cell. 2022 Aug;13(8):580-601. doi: 10.1007/s13238-021-00896-xIF: 13.6 Q1 B1. （封面）

10. Zhao K#, Wang M#, Gao S*, Chen J*. Chromatin architecture reorganization during somatic cell reprogramming. Current Opinion in Genetics & Development. 2021 Oct 70:104-113. https://doi.org/10.1016/j.gde.2021.07.006IF: 3.7 Q2 B2

11. Yang G#, Zhang L#, Liu W#, Qiao Z, Shen S, Zhu Q, Gao R, Wang M, Wang M, Li C, Liu M, Sun J, Wang L, Liu W, Cui X, Zhao K, Zang R, Chen M, Liang Z, Wang L, Kou X, Zhao Y, Wang H, Wang Y, Gao S*, Chen J*, Jiang C*. Dux-mediated corrections of aberrant H3K9ac during 2-cell genome activation optimized efficiency of somatic cell nuclear transfer. Cell Stem Cell. 2021 Oct 5:S1934-5909(20)30452-5. doi: 10.1016/j.stem.2020.09.006IF: 19.8 Q1 B1.

12. Zhang W#, Chen Y#, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J*, Gao S*, Mao Z*. A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing. Elife. 2020 Jul 9;9:e56008. doi: 10.7554/eLife.56008IF: 6.4 Q1 B1.

13. Chen Y#, Chen J#, Sun X#, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J*, Gao S*, Mao Z*. The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells. Aging Cell. 2020 Aug;19(8):e13185. doi: 10.1111/acel.13185IF: 8.0 Q1 B1.

14. He W#, Chen J#*, Gao S*. Mammalian haploid stem cells: establishment, engineering and applications. Cell Mol Life Sci. 2019 Jun;76(12):2349-2367. doi: 10.1007/s00018-019-03069-6IF: 6.2 Q1 B2. (#co-first authors, *Co-correspondence)

15. Gao H#, Gao R#, Zhang L#, Xiu W, Zang R, Wang H, Zhang Y, Chen J*, Gao Y*, Gao S*. Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs. Journal of Molecular Cell Biology. 2019 Jun 1;11(6):463-473. doi: 10.1093/jmcb/mjy054IF: 5.3 Q2 B2. (*Co-correspondence)

16. Li Y#, Zhang Z#, Chen J#, Liu W, Lai W, Liu B, Li X, Liu L, Xu S, Dong Q, Wang M, Duan X, Tan J, Zheng Y, Zhang P, Fan G, Wong J, Xu G, Wang Z, Wang H, Gao S, Zhu B*. Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1. Nature. 2018 Dec;564(7734):136-140. doi: 10.1038/s41586-018-0751-5IF: 50.5 Q1 B1. (#co-first authors)

17. Li J#, Shen S#, Chen J#, Liu W, Li X, Zhu Q, Wang B, Chen X, Wu L, Wang M, Gu L, Wang H, Yin J, Jiang C*, Gao S*. Accurate annotation of accessible chromatin in mouse and human primordial germ cells. Cell Research. 2018 Nov;28(11):1077-1089. doi: 10.1038/s41422-018-0096-5IF: 28.1 Q1 B1. (#co-first authors)

18. He W#, Zhang X#, Zhang Y, Zheng W, Xiong Z, Hu X, Wang M, Zhang L, Zhao K, Qiao Z, Lai W, Lv C, Kou X, Zhao Y, Yin J, Liu W, Jiang Y, Chen M, Xu R, Le R, Li C, Wang H, Wan X, Wang H, Han Z, Jiang C*, Gao S*, Chen J*. Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b. Stem Cell Reports. 2018 Feb 13;10(2):477-493. doi: 10.1016/j.stemcr.2017.12.024IF: 5.9 Q1 B2. (*Co-correspondence)

19. Liu W#, Bai D#, Chen J*, Gao S*. Additive-effect pattern of both ZP2 and ZP3 in human and mouse. Hum Genet. 2017 Nov;136(11-12):1493-1495. doi: 10.1007/s00439-017-1848-xIF: 3.8 Q2 B2. (*Co-correspondence)

20. Liu W#, Li K#, Bai D#, Yin J#, Tang Y, Chi F, Zhang L, Wang Y, Pan J, Liang S, Guo Y, Ruan J, Kou X, Zhao Y, Wang H, Chen J*, Teng X*, Gao S*. Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility. Hum Genet. 2017 Aug;136(8):975-985. doi: 10.1007/s00439-017-1822-7IF: 3.8 Q2 B2. (*Co-correspondence)

21. Gao R#, Xiu W#, Zhang L, Zang R, Yang L, Wang C, Wang M, Wang M, Yi L, Tang Y, Gao Y, Wang H, Xi J, Liu W, Wang Y, Wen X, Yu Y, Zhang Y, Chen L*, Chen J*, Gao S*. Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state. Biomaterials. 2017 Mar;119:53-67. doi: 10.1016/j.biomaterials.2016.12.007IF: 12.8 Q1 B1. (*Co-correspondence)

22. Xu K#, Chen X#, Yang H, Xu Y, He Y, Wang C, Huang H, Liu B, Liu W, Li J, Kou X, Zhao Y, Zhao K, Zhang L, Hou Z, Wang H, Wang H, Li J, Fan H, Wang F, Gao Y, Zhang Y, Chen J*, Gao S*. Maternal Sall4 Is Indispensable for Epigenetic Maturation of Mouse Oocytes. J Biol Chem. 2017 Feb 3;292(5):1798-1807. doi: 10.1074/jbc.M116.767061IF: 4.0 Q2 B2. (*Co-correspondence)

23. Chen J#*, Gao Y#, Huang H, Xu K, Chen X, Jiang Y, Li H, Gao S, Tao Y, Wang H, Zhang Y, Wang H, Cai T, Gao S*. The combination of Tet1 with Oct4 generates high-quality mouse induced pluripotent stem cells (iPSCs). Stem Cells. 2015 Mar;33(3):686-98. doi: 10.1002/stem.1879IF: 4.0 Q1 B2. 

24. Liu X#, Chen J#, Liu W, Li X, Chen Q, Liu T, Gao S*, Deng M*. The fused in sarcoma protein forms cytoplasmic aggregates in motor neurons derived from integration-free induced pluripotent stem cells generated from a patient with familial amyotrophic lateral sclerosis carrying the FUS-P525L mutation. Neurogenetics. 2015 Jul;16(3):223-31. doi: 10.1007/s10048-015-0448-yIF: 1.6 Q3 B4. 

25. Gao Y#, Chen J#, Li K, Wu T, Huang B, Liu W, Kou X, Zhang Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T and Gao S. Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell, 2013 Apr 4;12(4):453-69. doi: 10.1016/j.stem.2013.02.005IF: 19.8 Q1 B1. (Cover Story; Previewed by Cell Stem Cell; Selected as Best of 2013 by Cell Stem Cell)