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薛雷，北京大学学士，苏黎世大学博士，耶鲁大学医学院博士后；历任耶鲁大学医学院副研究员，霍华德修斯医学研究院研究专家，现任同济大学生命科学院教授。主要利用模式动物探寻和研究与器官发育、个体衰老、肿瘤发生与迁移、老年痴呆症、学习、记忆和求偶等行为相关的基因，以第一/通讯作者身份在Science等国际学术杂志发表SCI论文70余篇。获上海市“浦江人才”、教育部“新世纪优秀人才”、上海市“科技进步一等奖”、教育部“技术发明一等奖”。现任国际学术杂志Advance in Alzheimer‘s Disease主编，Frontiers in Cell and Developmental Biology和Frontiersin Cell Death副主编，Genes和Scientific Reports等多个杂志编委。
主要利用模式动物和人类培养细胞及临床样本，探寻和研究与器官发育、个体衰老、肿瘤发生与迁移、老年痴呆症、抑郁症、学习、记忆和求偶等行为相关的基因，破解疾病的发生机制。在细胞水平，发现调控细胞增殖、细胞迁移、细胞死亡、细胞生长、细胞自噬等行为的基因，研究其调控机制。
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支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg作为负责人主持的科研项目：
1. 国家重点基础研究发展计划
项目名称：形态发生素信号通路与JNK、Hippo信号通路的相互作用
项目编号：2011CB943903
项目时间：2011.1 – 2015.12
2． 国家自然科学基金
项目名称：prd基因在器官发育过程中的作用及机制研究
项目编号：30971681
项目时间：2010.1 – 2012.12
3． 国家自然科学基金
项目名称：泛素化修饰在TNF-JNK信号转导通路中的调控作用和机制研究
项目编号：31071294
项目时间：2011.1 – 2013.12
4． 国家自然科学基金
项目名称：JNK 信号通路新成员的功能研究
项目编号：31171413
项目时间：2012.1 – 2015.12
5． 国家自然科学基金
项目名称：肿瘤迁移的分子机制
项目编号：31371490
项目时间：2014.1 –2017.12
6． 国家自然科学基金
项目名称：JNK信号通路与Wg信号通路的相互作用及机制研究
项目编号：31571516
项目时间：2016.1 –2019.12
7． 国家自然科学基金
项目名称：JNK信号通路对细胞迁移的调控机制
项目编号：31771595
项目时间：2018.1 –2021.12
8． 国家自然科学基金
项目名称：RNA结合蛋白对JNK信号通路的调控作用及机制研究
项目编号：31970536
项目时间：2020.01 –2023.12
9． 教育部新世纪优秀人才支持计划
项目名称：JNK信号转导通路的作用及机制研究
项目编号：NCET-10-0608
项目时间：2010.1 – 2012.12
10．教育部博士学科点专项科研基金
项目名称：JNK信号通路新成员的功能研究
项目编号：20120072110023
项目时间：2013.1 – 2015.12
11．上海市科委浦江人才计划
项目名称： JNK信号转导通路新成分的筛选、鉴定和作用机制研究
项目编号：09PJ1409400
项目时间：2009.7 – 2011.6
12．上海市科委重点项目
项目名称：择偶偏好的神经网络机制
项目编号：14JC1406000
项目时间：2014.7 – 2017.6
13. 上海市科委国际合作项目
项目名称：Hippo信号通路调控JNK介导的细胞迁移和肿瘤浸润的机制研究
项目编号：18430711600
项目时间：2018.4 – 2021.3
14. 上海市科委重点项目
项目名称：果蝇AD模型的建立和应用
项目编号：18140900400
项目时间：2018.5 – 2021.4
15. 上海市教委科研创新项目
项目名称：TNF-JNK信号通路的作用及机制研究
项目编号：10ZZ27
项目时间：2010.1 – 2012.12
发表的论文(仅限通讯作者)：
1. LZhuang, C Li, F Peng, E Xue, W Li, X Sun, P Chen, Q Zhou and L Xue* (2023) Depletion of ESCRTameliorates APP-induced AD-like symptoms in Drosophila. J Cell Physiol. doi: 10.1002/jcp.31035.
2. XGuo, Z Li, X Zhu, M Zhan, C Wu, X Ding, K Peng, W Li, X Ma, Z Lv, L Lu and L Xue* (2022) A CoherentFOXO3-SNAI2 Feed-Forward Loop in Autophagy. PNAS 119:e2118285119.
3. YPan, W Li, Z Deng, Y Sun, X Ma, R Liang, X Guo, Y Sun, W Li, R Jiao and L Xue* (2022) Myc suppressesmale-male courtship in Drosophila. EMBO J 41:e109905.
4. XGuo, X Ma, L Xue* (2022) Aconserved interplay between FOXO and SNAI/Snail in autophagy.Autophagy 18:2759-2760.
5. XDing, Z Li, K Peng, R Zou, C Wu, G Lin, W Li and L Xue* (2022) Snail regulates Hippo signaling-mediated cellproliferation and tissue growth in Drosophila. Open Biology 12:210357.
6. XDing, Z Li, G Lin, W Li and L Xue*(2022) Toll-7 promotes tumor growth and invasion in Drosophila. CellProliferation 55:e13188.
7. YSun, Z Li, W Li and L Xue*(2022) Loss of Bicra impairs Drosophila learning and choiceabilities. Neuroscience Letters 769:136432.
8. MXu, P Ren, J Tian, L Xiao, P Hu, P Chen, W Li, L Xue* (2022) dGLYAT modulates Gadd45-mediated JNKactivation and cell invasion. Cell Division. 17:4.
9. XGuo, C Wu, Y Pan, X Zhu, K Peng, X Ma, LXue* (2022) Mechanistic insights and implications of FOXO-SNAIinterplay. Bioessays 44:e2200070.
10. CWu, X Ding, Z Li, Y Huang, Q Xu, R Zou, M Zhao, H Chang, C Jiang, X La, G Lin,W Li, L Xue* (2021) CtBPmodulates Snail-mediated tumor invasion in Drosophila. Cell Death Discovery7:202.
11. XGuo, YSun, T Azad, H J Rensburg, J Luo, S Yang, P Liu, Z Lv, M Zhan, L Lu, YZhou, X Ma, X Zhang, X Yang, L Xue*(2020) Rox8 promotes microRNA-dependent yki messenger RNA decay. PNAS117:30520-30530.
12. LZhuang, F Peng, Y Huang, W Li, J Huang, Y Chu, P Ren, Y Sun, Y Zhang, E Xue, XGuo, X Shen, L Xue* (2020)CHIP modulates APP-induced autophagy-dependent pathological symptoms inDrosophila. Aging Cell 19:e13070.
13. ZLi, C Wu, X Ding, W Li, L Xue*(2020) Toll signaling promotes JNK-dependent apoptosis in Drosophila. CellDivision 15:7.
14. CWu, Z Li, X Ding, X Guo, Y Sun, X Wang, Y Hu Y, T Li, X La, J Li, J Li, W Li, L Xue* (2019) Snail modulatesJNK-mediated cell death in Drosophila. Cell Death Disease 10:893.
15. SZhang, X Guo, H Wu, Y Sun, X Ma, J Li, Q Xu, C Wu, Q Li, C Jiang, W Li, MS Ho,Z Lv, and L Xue* (2019)Wingless modulates activator protein-1-mediated tumor invasion. Oncogene38: 3871-3885.
16. YSun, D Zhang, X Guo, W Li, C Li, J Luo, M Zhou and L Xue* (2019) MKK3 modulates JNK-dependent cell migrationand invasion. Cell Death Disease 10:149.
17. YSun, D Zhang, C Li, J Huang, W Li, Y Qiu, A Mao, M Zhou and L Xue* (2019) Lic regulates JNK-mediatedcell death in Drosophila. Cell Proliferation 52: e12593.
18. XMa, X Guo, HE Richardson, T Xu and LXue* (2018) POSH regulates Hippo signaling through ubiquitin-mediatedexpanded degradation. PNAS 115:2150-2155.
19. XWang, X Huang, C Wu and L Xue*(2018) Pontin/Tip49 acts as a novel regulator of JNK pathway. CellDeath Disease 9: 978.
20. XWang, X Huang, C Wu and L Xue*(2018) Pontin/Tip49 negatively regulates JNK-mediated cell death in Drosophila. CellDeath Discovery 4:74.
21. XWang, X Guo, Y Ma, C Wu, W Li and LXue* (2018) APLP2 Modulates JNK-Dependent Cell Migration in Drosophila.BioMedResearch International: Article ID 7469714.
22. XMa, H Wang, J Ji, W Xu, Y Sun, W Li, X Zhang, J Chen and L Xue* (2017) Hippo Signaling Promotes JNK-dependent CellMigration. PNAS 114:1934-1939.
23. XMa, J Huang, Y Tian,Y Chen, Y Yang, X Zhang, F Zhang and L Xue* (2017) MycSuppresses Tumor Invasion and Cell Migration by inhibiting JNK Signaling. Oncogene36: 3159-3167.
24. JHuang, Y Feng, X Chen, W Li and L Xue*(2017) Myc inhibits JNK-mediated cell death in vivo. Apoptosis 22:479-490.
25. PRen, W Li and L Xue* (2017)GLYAT regulates JNK-mediated cell death in Drosophila. Scientific Reports7:5183.
26. LZhuang, Y Sun, M Hu, C Wu, X La, X Chen, Y Feng, X Wang, Y Hu and L Xue*(2016) Or47b plays a role in Drosophila males’ preference for younger mates. OpenBiology 6: 160086.
27. S Zhang, XGuo, C Chen, Y Chen, J Li, Y Sun, C Wu, Y Yang, C Jiang, W Li and L Xue* (2016) dFoxO promotes Wingless signaling inDrosophila. ScientificReports 6:22348.
28. XMa, Y Chen, S Zhang, W Xu, Y Shao, Y Yang, W Li, M Li* and L Xue* (2016)Rho1–Wnd signaling regulates loss-of-cell polarity-induced cell invasion inDrosophila. Oncogene 35, 846–855.
29. XMa, Y Chen, W Xu, N Wu, M Li, Y Cao, S Wu, Q Li and L Xue* (2015) Impaired Hippo signaling promotesRho1-JNK-dependent growth. PNAS 112:1065-70.
30. CWu, Y Chen, F Wang, C Chen, S Zhang, C Li, W Li, S Wu and L Xue* (2015) Pelle Modulates dFoxO-Mediated Cell Death inDrosophila. PLOS Genetics 11:e1005589.
31. FPeng, Y Zhao, X Huang, C Chen, L Sun, L Zhuang and L Xue* (2015) Loss of Polo ameliorates APP-inducedAlzheimer’s disease-like symptoms in Drosophila. Scientific Reports5:16816.
32. YHu, Y Han, Y Shao, X Wang, Y Ma, E Ling and L Xue* (2015) Gr33a Modulates Drosophila Male CourtshipPreference. Scientific Reports 5:7777.
33. X Ma, W Xu, D Zhang, Y Yang, W Li and LXue* (2015)Wallenda regulates JNK-mediated cell death in Drosophila. Cell Death Disease 6,e1737.
34. S Zhang, C Chen, C Wu, Y Yang, W Li and L Xue* (2015) The canonical Wg signaling modulates Bsk-mediated cell death inDrosophila. Cell Death Disease 6, e1713.
35. CWu, C Chen, J Dai, F Zhang, Y Chen, W Li, J Pastor-Pareja and L Xue*(2015) Toll pathway modulates TNF-induced JNK-dependent cell death inDrosophila. Open Biology 5: 140171.
36. LLi, P Li and L Xue* (2015)The RED domain of Paired is specifically required for Drosophila accessorygland maturation. Open Biology 5: 140179.
37. JHuang and L Xue* (2015) Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. BioMedResearch International: Article ID 623573.
38. XWang, Y Ma, Y Zhao, Y Chen, Y Hu, C Chen, Y Shao and L Xue* (2015) APLP1 promotes dFoxO-dependent cell death inDrosophila. Apoptosis 20, 778-786.
39. XWang, Z Wang, Y Chen, X Huang, Y Hu, R Zhang, M S Ho and L Xue* (2014) FoxO Mediates APP-Induced AICD-Dependent CellDeath. Cell Death Disease 5, e1233.
40. YHu, Y Han, X Wang and L Xue*(2014) Aging-related Neurodegeneration Eliminates Male Courtship Choice in Drosophila. Neurobiology of Aging 35,2174-2178.
41. X Ma, W Li, H Yu, Y Yang, M Li, L Xue* and T Xu* (2014) Bendlessmodulates JNK-mediated cell death and migration in Drosophila. Cell Death Differentiation 21,407-415.
42. HYang, W Li, H Yu, R Yuan, Y Yang, K Pung, P Li and L Xue* (2013) Physiological Effects of L-Theanine onDrosophila melanogaster. Molecules 18, 13175-13187.
43. XMa, Y Shao, H Zheng, M Li, W Li and LXue* (2013) Src42A modulates tumor invasion and cell death viaBen/dUev1a-mediated JNK activation in Drosophila.CellDeath Disease 4, e864.
44. XMa, L Yang, Y Yang, M Li, W Li and LXue* (2013) dUev1aModulates TNF-JNK Mediated Tumor Progression and Cell Death in Drosophila. Development Biology 380,211-221.
45. XMa, J Huang, Y Yang, W Li and L Xue*(2012) NOPO Modulates Egr- induced JNK- independent cell death in Drosophila. Cell Research 22,425-431.
Li and L Xue* (2015)The RED domain of Paired is specifically required for Drosophila accessorygland maturation. Open Biology 5: 140179.
37. JHuang and L Xue* (2015) Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. BioMedResearch International: Article ID 623573.
38. XWang, Y Ma, Y Zhao, Y Chen, Y Hu, C Chen, Y Shao and L Xue* (2015) APLP1 promotes dFoxO-dependent cell death inDrosophila. Apoptosis 20, 778-786.
39. XWang, Z Wang, Y Chen, X Huang, Y Hu, R Zhang, M S Ho and L Xue* (2014) FoxO Mediates APP-Induced AICD-Dependent CellDeath. Cell Death Disease 5, e1233.
40. YHu, Y Han, X Wang and L Xue*(2014) Aging-related Neurodegeneration Eliminates Male Courtship Choice in Drosophila. Neurobiology of Aging 35,2174-2178.
41. X Ma, W Li, H Yu, Y Yang, M Li, L Xue* and T Xu* (2014) Bendlessmodulates JNK-mediated cell death and migration in Drosophila. Cell Death Differentiation 21,407-415.
42. HYang, W Li, H Yu, R Yuan, Y Yang, K Pung, P Li and L Xue* (2013) Physiological Effects of L-Theanine onDrosophila melanogaster. Molecules 18, 13175-13187.
43. XMa, Y Shao, H Zheng, M Li, W Li and LXue* (2013) Src42A modulates tumor invasion and cell death viaBen/dUev1a-mediated JNK activation in Drosophila.CellDeath Disease 4, e864.
44. XMa, L Yang, Y Yang, M Li, W Li and LXue* (2013) dUev1aModulates TNF-JNK Mediated Tumor Progression and Cell Death in Drosophila. Development Biology 380,211-221.
45. XMa, J Huang, Y Yang, W Li and L Xue*(2012) NOPO Modulates Egr- induced JNK- independent cell death in Drosophila. Cell Research 22,425-431.
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