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同济大学附属皮肤病医院/上海市皮肤病医院副主任；中国康复医学会光动力治疗与康复专委会常委；中国康复医学会皮肤病康复专委会青年工作组副组长；中国康复医学会皮肤病康复分会无创诊断学组副组长，上海市女医师协会皮肤美容美学专委会常委兼秘书长；中国整形美容协会皮肤美容分会玫瑰痤疮与面部敏感皮肤学组委员；中国抗癌协会光动力治疗肿瘤专委会委员；中国临床肿瘤学会肿瘤光动力治疗专委会委员；中国生物医学工程学会生物医学光子学分会青年委员；国际光动力协会会员。
Associate chief physician of Skin Disease hospital of Tongji University / Shanghai Skin Disease Hospital; Deputy leader of Youth Group of Chinese Association of Rehabilitation Dermatology; Deputy leader of Non invasive Diagnosis Group of Chinese Association of Rehabilitation Dermatology; Deputy Chairman of Youth Committee of Laser Medical specialty Branch of Shanghai Medical Association；Shanghai Association of women physicians skin care aesthetics standing committee member and secretary General; Skin Beauty Branch of China Plastic Surgery Association，Member of the Rosacea and Sensitive Facial Dermatology Group；Chinese Society of Biomedical Engineering, Biomedical Photonics Youth Committee member; Member of International Photodynamic Association.
北京大学博士，美国密歇根大学访问学者。入选上海市青年科技启明星计划，上海市浦江人才计划，上海市卫计委新优青人才计划，首届长宁区青年创新英才计划。获得第十九届“银蛇奖”提名奖，上海第三届“医树奖”青年临床医学科技创新奖。主持市局级以上课题8项，包括国家自然科学基金2项，作为研究骨干参与科技部重点研发计划。发表第一作者或通讯作者SCI论文42篇，中文核心期刊9篇。获中国康复医学会科学技术奖一等奖2项，华夏医学科技奖二等奖1项、上海市科技进步奖三等奖1项，国家专利3项。
Dr. Peiru Wang received M.D from Peking University. She visited University of Michigan as visiting scholar doing research on skin aging and photoaging for 2 years. She was enrolled into the Shanghai Pujiang Program, the Shanghai Municipal Health and Family Planning Commission's New Talent Program, the Shanghai Rising-Star Program, and the first Changning District Youth Innovative Talent Program. She won the 19th Shanghai “Silver Snake Award” Nomination Award and Shanghai 3rd "Medical Tree Award" Young Clinical Medical Science and Technology Innovation Award in Shanghai. She received 8 grants, including 2 programs from the National Natural Science Foundation of China, and participated in the key research and development plan of the Ministry of Science and Technology. She Published 42 SCI papers as first author and 9 Chinese core journals. She won 1 first prize of the Science and Technology Award of the Chinese Society of Rehabilitation Medicine, 1 second prize of China Medical Science and Technology Award, 1 third prize of Shanghai Science and Technology Progress Award, and 3 national patents.
光医学治疗科团队聚焦光医学技术在皮肤科中的应用近30年，世界首创光动力治疗尿道尖锐湿疣、开创中国ALA-光动力（ALA-PDT）治疗皮肤肿瘤新时代，开拓ALA-光动力治疗中重度痤疮新体系；全国率先开展和规范红蓝光及药物面膜综合治疗痤疮并获新技术准入。
先后牵头制定《氨基酮戊酸光动力疗法临床应用专家共识》（2015版）、《紫外线治疗皮肤病临床应用专家共识》（2019版）、《氨基酮戊酸光动力疗法皮肤科临床应用指南》（2021版，同步英文版发表于国际光动力权威杂志PDPDT，是中国皮肤科临床指南SCI杂志的首次国际发表）、《中国光线性角化病诊疗专家共识》、《Clinical practice Guidelines for 5-Aminolevulinic acid photodynamic therapy for acne vulgaris in China》（2023版）。
目前是美国哈佛大学、美国密西根大学以及德国慕尼黑大学长期合作交流单位，中华医学会皮肤性病学分会"光动力治疗研究中心"组长单位和培训基地，中国康复医学会皮肤光动力治疗康复技术培训基地牵头单位，中国抗癌协会肿瘤光动力治疗专委会"皮肤肿瘤光动力治疗"培训基地，中国中西医结合学会"优秀痤疮临床诊疗示范基地"，中国医学装备协会人工智能联盟示范单位，华夏皮肤影像人工智能协作组协作单位。
学科聚焦"光老化/老年斑/皮肤肿瘤、痤疮、瘢痕、血管瘤"四大专病以及"光医学皮肤无创诊断中心"，并已逐步形成光医学特色诊疗平台。学科先后获科技部重点研发子课题2项、国家自然基金26项、人事部回国留学人员基金、上海市重点科研课题等课题30余项，在皮肤科和肿瘤领域权威期刊及国际光动力权威杂志上发表SCI论文300余篇。获中国康复医学会科技一等奖2项、华夏医学二等奖1项、中华医学科技奖三等奖1项、上海市科技成果3项、上海市科技进步奖3项、上海市医学奖2项，国家专利7项。
主持市局级以上课题9项，包括国家自然科学基金2项，作为研究骨干参与多项科技部重点研发计划。
主持市局级以上课题8项，包括国家自然科学基金2项，作为研究骨干参与多项科技部重点研发计划。
发表SCI论文43篇，中文核心期刊9篇。参与发表论文80余篇。参与制定《中国光线性角化病临床诊疗专家共识（2021）》《Clinical practice Guidelines for 5-Aminolevulinic acid photodynamic therapy for acne vulgaris in China（中国氨基酮戊酸光动力疗法治疗寻常痤疮的临床实践指南）英文指南》。获中国康复医学会科学技术奖一等奖2项、华夏医学科技奖二等奖1项、上海市科技进步奖三等奖1项，国家专利2项。参编著作12部。
1. Zhang L#, Wang P#, Shi L, Zhang G, Zhang Y, Zhou Z, Huang Z, Wang H*, Wang X*. Topical 5-aminolevulinic acid photodynamic therapy improved refractory acne conglobata and perifolliculitis capitis abscedens et suffodiens rather than hidradenitis suppurativa. Journal of Innovative Optical Health Sciences, 2016, 09(01): 1640002.
2. Wang P#, Wang H#, Ding H, Lv T, Miao F, Li J, Shi L, Wang X*. Risk factors, psychological impacts and current treatments of acne in Shanghai area of China. J Dermatolog Treat. 2016;27(2):146-7. doi: 10.3109/09546634.2015.1061184. PubMed PMID: 26194720.
3. Wang P#, Sun M#, Lei D, Okubo T, Voorhees JJ, Fisher GJ*, Li Y*. Prostaglandins Contribute to the Effects of Solar Ultraviolet Irradiation on Type I Collagen and Matrix Metalloproteinase-1 Expression in Human Skin. The Journal of investigative dermatology. 2016;136(10):2105-7. doi: 10.1016/j.jid.2016.05.120. PubMed PMID: 27349863.
4. Wang P#, Sun M, Ren J, Djuric Z, Fisher GJ, Wang X*, Li Y*. Gas chromatography-mass spectrometry analysis of effects of dietary fish oil on total fatty acid composition in mouse skin. Scientific reports. 2017;7:42641. doi: 10.1038/srep42641. PubMed PMID: 28195161; PMCID: 5307384.
5. Wang P#, Sun M, Voorhees JJ, Fisher GJ*, Li Y*. Cyclooxygenases mediate early induction of interleukin-6 expression by solar ultraviolet irradiation in human skin. Journal of dermatological science. 2017;87(2):201-3. doi: 10.1016/j.jdermsci.2017.05.006. PubMed PMID: 28551093.
6. Bhatta AK#, Wang P#, Keyal U, Zhao Z, Ji J, Zhu L, Wang X*, Zhang G*. Therapeutic effect of Imiquimod enhanced ALA-PDT on cutaneous squamous cell carcinoma. Photodiagnosis and photodynamic therapy. 2018;23:273-80. Epub 2018/07/22. doi: 10.1016/j.pdpdt.2018.07.010. PubMed PMID: 30030167.
7. Wang P#, Han J#, Wei M, Xu Y, Zhang G, Zhang H, Shi L, Liu X, Hamblin MR, Wang X*. Remodeling of dermal collagen in photoaged skin using low-dose 5-aminolevulinic acid photodynamic therapy occurs via the transforming growth factor-beta pathway. J Biophotonics. 2018. doi: 10.1002/jbio.201700357. PubMed PMID: 29431281.J Biophotonics
. 2018 Jun;11(6):e201700357. doi: 10.1002/jbio.201700357. Epub 2018 Mar 12.
8. Wang P#, Sun M, Ren J, Aslam MN, Xu Y, Fisher GJ, Voorhees JJ, Wang X*, Li Y*. Dietary Fish Oil Supplementation Enhances Expression of Genes Involved in Cornified Cell Envelope Formation in Rat Skin. The Journal of investigative dermatology. 2018;138(4):981-3. doi: 10.1016/j.jid.2017.11.019. PubMed PMID: 29203358.
9. Wang P#, Zhang L, Zhang G, Zhou Z, Zhang H, Zhao Z, Shi L, Wang X*. Successful treatment of giant invasive cutaneous squamous cell carcinoma by plum-blossom needle assisted photodynamic therapy sequential with imiquimod: Case experience. Photodiagnosis and photodynamic therapy. 2018;21:393-5. doi: 10.1016/j.pdpdt.2017.12.010. PubMed PMID: 29277296.
10. Wu Y#, Wang P#, Zhang L, Wang B, Wang X*. Enhancement of Photodynamic Therapy for Bowen's Disease Using Plum-Blossom Needling to Augment Drug Delivery. Dermatologic surgery: official publication for American Society for Dermatologic Surgery [et al]. 2018;44(12):1516-24. Epub 2018/07/12. doi: 10.1097/DSS.0000000000001608. PubMed PMID: 29994952.
11. Zhu L#, Wang P#, Zhang G, Zhang L, Liu X, Hu C, Yang X, Sroka R, Zhou Z, Wang X*. Conventional versus daylight photodynamic therapy for actinic keratosis: A randomized and prospective study in China. Photodiagnosis and photodynamic therapy. 2018; 24: 366-71. Epub 2018/10/20. doi: 10.1016/j.pdpdt.2018.10.010. PubMed PMID: 30336290.
12. Wang P#, Zhang L, Shi L, Yuan C, Zhang G, Wang X*. Latent Demodex infection contributes to intense pulsed light aggravated rosacea: cases serial. J Cosmet Laser Ther. 2019;21(3):163-5. Epub 2018/07/25. doi: 10.1080/14764172.2018.1502448. PubMed PMID: 30040520.
13. Wang P#, Yang W#, Shen S#, Wu C, Wen L, Cheng Q, Zhang B*, Wang X*. Differential Diagnosis and Precision Therapy of Two Typical Malignant Cutaneous Tumors Leveraging Their Tumor Microenvironment: A Photomedicine Strategy. ACS nano. 2019;13(10):11168-80. Epub 2019/10/05. doi: 10.1021/acsnano.9b04070. PubMed PMID: 31585038.
14. Cao Y#, Wang P#, Zhang G, Hu C, Zhang H, Wang X*. Administration of skin care regimens containing beta-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study. J Cosmet Dermatol. 2021;20(6):1756-62. Epub 2020/11/01. doi: 10.1111/jocd.13798. PubMed PMID: 33128496.
15. Yan J#, Wang P#, Li L, Zhang L, Zhang G, Tang Y*, Wang X*. Surgery sequential with 5-Aminolevulinic acid photodynamic therapy for the lip squamous cell carcinoma: Two cases reports. Photodiagnosis and photodynamic therapy. 2020:102043. Epub 2020/10/04. doi: 10.1016/j.pdpdt.2020.102043. PubMed PMID: 33010483.
16. Wang P#, Yan G#, Xue H, Shen S, Cao Y, Zhang G*, Wang X*. Proteomics and lipidomics reveal the protective mechanism of dietary n-3 PUFA supplementation for photoaging. Food Funct. 2021. Epub 2021/07/10. doi: 10.1039/d0fo03228j. PubMed PMID: 34241612.
17. Wang P#, Zhang G#, Zhang L, Zhou Z, Shi L, Zeng Q, Zhu L, Wang X*. 5-Aminolevulinic acid photodynamic therapy for early-stage lip squamous cell carcinoma. Photodiagnosis and photodynamic therapy. 2021;35:102321. Epub 2021/05/21. doi: 10.1016/j.pdpdt.2021.102321. PubMed PMID: 34015543.
18. Shen S, Liu X, Yang X, Hu C, Wang P*, Wang X*. A combination of laser-assisted ALA-PDT for squamous cell carcinoma in situ and field-directed ALA-PDT for actinic keratosis. Photodiagnosis and photodynamic therapy. 2022;37:102638. Epub 2021/11/25. doi: 10.1016/j.pdpdt.2021.102638. PubMed PMID: 34818597.
19. Wang D#, Wang P#, Li C, Zhou Z, Zhang L, Zhang G, Wang X*. Efficacy and safety of HpD-PDT for Extramammary Paget's Disease refractory to conventional therapy: A prospective, open-label and single arm pilot study. Photodiagnosis and photodynamic therapy. 2022;37:102670. Epub 2021/12/10. doi: 10.1016/j.pdpdt.2021.102670. PubMed PMID: 34883272.
20. Li J, Li J, Zhang L, Liu X, Cao Y, Wang P*, Wang X*. Comparison of red light and blue light therapies for mild-to-moderate acne vulgaris: A randomized controlled clinical study. Photodermatol Photoimmunol Photomed. 2022 Jan 3. doi: 10.1111/phpp.12769. Epub ahead of print. PMID: 34981580.
21. Yang Y, Shen S, Wang P*, Wang X*. Efficacy of photodynamic therapy in actinic cheilitis: A systematic review. Photodiagnosis and photodynamic therapy. 2022;38:102782. Epub 2022/02/27. doi: 10.1016/j.pdpdt.2022.102782. PubMed PMID: 35218940.
22. Yang Y, Shen S, Cao Y, Wang D, Kang Z, Wang P*, Wang X*. Remodeling Lymphatic Vessels in Intrinsically Aged Skin on SKH-1 Mouse Using Low Dose 5-aminolevulinic Acid Photodynamic Therapy via VEGF-C/VEGFR3 Pathway. Photodiagnosis Photodyn Ther. 2022 Jun;38:102851. doi: 10.1016/j.pdpdt.2022.102851. Epub 2022 Apr 6. PMID: 35398260.
23. Li C#, Wang P#, Wang D, Shi L, Zhou Z, Zhang L, Zhang G, Chen C, Wang X. Fluorescence kinetics study of twice laser irradiation based HpD-PDT for nonmelanoma skin cancer. Lasers in surgery and medicine. 2022. Epub 2022/04/08. doi: 10.1002/lsm.23538. PubMed PMID: 35391497.
24. Cao Y#, Wang P#, Liu X, Zhang G, Cao Z, Xue H, He Q, Wang X. Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser: A prospective randomized vehicle-controlled parallel group study. J Dermatol. 2022 May 15. doi: 10.1111/1346-8138.16417. Epub ahead of print. PMID: 35570397.
25. Shuzhan Shen, Yajing Cao, Jiandan Li, Xiaojing Liu, Zhongxia Zhou, Xiuli Wang* and Peiru Wang*. Novel intense pulsed light-photodynamic therapy strategy in the treatment of facial actinic keratoses concomitant with rosacea Journal of Innovative Optical Health SciencesVol. 15, No. 04, 2240005 (2022) Special Issue ArticleOpen Access
26. Xue H, Shen S, Yan G, Yang Y, Li J, Kang Z, Cao Y, Wang X*, Wang P*. A dose-dependent protective effect of n-3 PUFAs in photoaging by promoting collagen production through MAPK pathway in SKH-1 mouse model. J Cosmet Dermatol. 2022 Nov;21(11):6225-6232. doi: 10.1111/jocd.15220. Epub 2022 Sep 25. PMID: 35808862.
27. Wang D, Li C, Zhou Z, Zhang Y, Zhang G, Wang P*, Wang X*. Photodynamic therapy of intravenous injection combined with intratumoral administration of photosensitizer in squamous cell carcinoma. Photodiagnosis Photodyn Ther. 2022 Jun;38:102857. doi: 10.1016/j.pdpdt.2022.102857. Epub 2022 Apr 8. PMID: 35405274.
28. Shen S, Yan G, Cao Y, Zeng Q, Zhao J*, Wang X*, Wang P*. Dietary supplementation of n-3 PUFAs ameliorates LL37-induced rosacea-like skin inflammation via inhibition of TLR2/MyD88/NF-κB pathway. Biomed Pharmacother. 2023 Jan;157:114091. doi: 10.1016/j.biopha.2022.114091. Epub 2022 Dec 5. PMID: 36481403.
29. Wang P#, Wang B#, Zhang L#, Liu X, Shi L, Kang X, Lei X, Chen K, Chen Z, Li C, Zhang C, Tu P, Pan M, Ju Q, Man X, Lu Y, Yu N, Li Y, Zhu H, Zhang R, Su J, Tao S, Qiao J, Mu Q, Zeng W, Li Z, Gao Y, Gu H, Wang X. Clinical practice Guidelines for 5-Aminolevulinic acid photodynamic therapy for acne vulgaris in China. Photodiagnosis Photodyn Ther. 2022 Dec 30;41:103261. doi: 10.1016/j.pdpdt.2022.103261. Epub ahead of print. PMID: 36587863.
30. Yang Y, Wang X*, Wang P*. Signaling mechanisms underlying lymphatic vessel dysfunction in skin aging and possible anti-aging strategies. Biogerontology. 2023 Jan 21. doi: 10.1007/s10522-023-10016-3. Epub ahead of print. PMID: 36680698.
31. Li J#, Liu X#, Du Q, Wang X*, Wang P*. Porokeratotic lichen planus of the lower extremities. Australas J Dermatol. 2023 Mar 15. doi: 10.1111/ajd.14017. Epub ahead of print. PMID: 36920437.
32. Yutong Yang, Jia Yan, Lei Shi, Linglin Zhang, Xiaojing Liu, Fuquan Long*, Peiru Wang*, Xiuli Wang*, "Hyaluronic Acid Dissolving Microneedles and Nonablative Fractional Laser for Infraorbital Wrinkles: A Prospective, Randomized, Split-Face Study", Dermatologic Therapy, vol. 2023, Article ID 2087120, 7 pages, 2023. https://doi.org/10.1155/2023/2087120
33. Wang P#, Xie F#, Zhang L, Zhao S, Zhu L, Shen S, Li D, Chen Z, Xiao R, Lu Y, Lei X, Li Y, Zhang G, Zeng W*, Wang X*. Plum-blossom needle tapping enhances the efficacy of ALA photodynamic therapy for facial actinic keratosis in Chinese population: a randomized, multicenter, prospective, and observer-blind study. Photodiagnosis Photodyn Ther. 2023 May 19;42:103611. doi: 10.1016/j.pdpdt.2023.103611. Epub ahead of print. PMID: 37211296.
34. Yan Y, Yan G, Cao Z, Wang B, Zeng Q, Shi L, Chang Q, Chen C, Zhang L, Liao C, Jin S, Sun X, Zhang G, Wang P*, Wang X*. Single cell transcriptome profiling reveals cutaneous immune microenvironment remodeling by photodynamic therapy in photoaged skin. Front Immunol. 2023 Jun 19;14:1183709. doi: 10.3389/fimmu.2023.1183709. PMID: 37404811; PMCID: PMC10315469.
35. Li J#, Zhang Y, Zhang G, Zhang L, Zhou Z, Wang P*, Wang X*. Modified painless photodynamic therapy for facial multiple actinic keratosis in China: A prospective split-face control study. Lasers Surg Med. 2023 Oct 9. doi: 10.1002/lsm.23728. Epub ahead of print. PMID: 37814511.
36. Yang YL, Zhou C, Chen Q, Shen SZ, Li JD, Wang XL, Wang PR*. YAP1/Piezo1 involve in the dynamic changes of lymphatic vessels in UVR-induced photoaging progress to squamous cell carcinoma. J Transl Med. 2023 Nov 16;21(1):820. doi: 10.1186/s12967-023-04458-z. PMID: 37974224; PMCID: PMC10655279.
37. Xu HY#, Wen L#, Hu C, Li JD, Wang PR*, Wang XL*. Dermoscopy combined with reflectance confocal microscopy as a noninvasive involvement for monitoring Cutaneous Rosai-Dorfman: A case report. Photodiagnosis Photodyn Ther. 2023 Nov 7;44:103874.
38. Gao J#, Zhang H#, Zhou Z, Sun X, Zhang G, Wang P*, Wang X*. The combination of holmium laser and ALA-PDT for Bowenoid Papulosis with diffuse large B-cell lymphoma. Photodiagnosis Photodyn Ther. 2023 Dec 23;45:103953. doi: 10.1016/j.pdpdt.2023.103953. Epub ahead of print. PMID: 38145769.
39. Yin X#, Yan Y, Li J, Cao Z, Shen S, Chang Q, Zhao Y, Wang X, Wang P*. Nuclear receptors for epidermal lipid barrier: Advances in mechanisms and applications. Exp Dermatol. 2024 Jun;33(6):e15107. doi: 10.1111/exd.15107. PMID: 38840418.
40. Kang Z#, Wang P#, Wang B, Yan Y, Zhao Z, Li C, Wen L, Wu M, Yan G, Wang X*, Zhang G*, Zeng Q*. Echinatin suppresses cutaneous squamous cell carcinoma by targeting GSTM3-mediated ferroptosis. Phytomedicine. 2024 Aug;131:155752. doi: 10.1016/j.phymed.2024.155752. Epub 2024 May 26. PMID: 38833947.
41. Yan J#, Wang B#, Zhang G, Liao C, Zhao Z, Wang P*, Wang X*. Neoadjuvant Photodynamic Therapy: An Updated Therapeutic Approach for Non-Melanoma Skin Cancers. Curr Treat Options Oncol. 2024 Jun;25(6):813-826. doi: 10.1007/s11864-024-01209-0. Epub 2024 May 18. PMID: 38761266.
42. Wu Y#, Yan Y#, Zhang L, Liu X, Yang J, Cao Y, Chang Q, Yan J, Zeng Q, Wang P*, Wang X*. Positive Results of Intense Pulsed Light-Photodynamic Therapy for Moderate-to-Severe Rosacea: A Prospective, Single-Arm Study. J Am Acad Dermatol. 2024 Jul 4:S0190-9622(24)01002-8. doi: 10.1016/j.jaad.2024.06.063. Epub ahead of print. PMID: 38971190.
43. Li C, Wan Y, Yang J, Feng C, Liu J, Cao Z, Li C, Wang P*, Wang X*, Zeng Q*. Ultra-small platinum nano-enzymatic spray with ROS scavenging and anti-inflammatory properties for photoaging treatment. Int J Biol Macromol. 2024 Sep 18;280(Pt 2):135743. doi: 10.1016/j.ijbiomac.2024.135743. Epub ahead of print. PMID: 39304038.
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