同济大学附属同济医院心血管内科为上海市重点学科，教育部硕博士学位点，博士后流动站，首批国家心血管专科医师规范化培训基地，国家心血管疾病介入诊疗培训基地（冠心病介入、心律失常介入），国家卫健委人才中心心律失常诊疗培训基地，国家放射与治疗临床医学中心核心单位；同济医院心内科为涵盖中国胸痛中心、房颤中心，心衰中心，高血压达标中心和国家标准化肺血管病中心、心肌病诊疗中心等综合性心血管疾病诊疗中心。拥有心血管重症监护、冠脉介入、心脏电生理起搏、心律失常消融治疗、结构性心脏病介入治疗、肺血管病介入治疗、心力衰竭、高血压、超声心动、无创心电检查和心脏康复等专业组，亚专科齐全，诊疗规范，在国内具有多项特色优势技术。倡导“以病人为中心，规范诊治”的科室文化。科室目前拥有医师32名，全部为硕士研究生及以上学历，高级职称20名，博士生导师3名，硕士生导师7名。

常规开展复杂冠脉介入治疗，包括正逆向技术开通CTO、严重钙化旋磨及激光治疗、左主干分叉双支架术等；24小时全天候“绿色通道”救治急性心梗具有极高成功率；ECMO等生命支持下救治暴发性心肌炎在上海处于领先；学科应用腔内影像和生理评估等先进技术指导疑难、复杂冠心病诊治在国内处于领先。常规开展预防房颤脑卒中的左心耳封堵术，开展房缺、室缺等封堵术，开展TAVI等瓣膜病介入治疗。开展肺血管介入治疗、肥厚心肌化学消融术和冠脉瘘封堵术获得良好益处；运用三维标测射频消融和冷冻消融技术治疗房颤、室速等复杂心律失常。国内和上海较早拥有及开展希氏束生理起搏技术，及全皮下植入式心律转复除颤器，常规开展单双腔起搏、CRT、ICD治疗缓慢型心律失常、心力衰竭及预防心源性猝死。在肺血管病、心衰、高血压、高脂血症和血栓性疾病等慢病管理中，运用个体化优化药物治疗和心脏康复具有技术特色，并被美国心脏病学院授予“心血管慢病管理成员单位”。多个临床案例被【中国临床案例成果数据库】收录，其中4项被评为全国优秀案例。

在JACC分册、EuroIntervention、JAHA及Metabolism等欧美权威期刊发表系列开创性心血管临床相关性研究成果；在美国AHA、TCT，欧洲ESC及韩国和巴西等国际著名心血管会议交流学术成果。在国内推广优化冠脉介入技术及精准治疗理念。主持国家973、863专项课题、国家自然科学基金和上海市科委重点临床研究项目等30余项。荣获上海市科技进步一等奖，上海市科学技术发明一等奖、教育部科学技术进步一等奖等多项科技成果。

作为项目负责人主持国家自然科学基金项目3项、上海市科技创新行动计划重点项目1项、国家科技部项目1项、上海市优秀学术带头计划1项、上海市医学领军人才计划1项、上海市科委产学研医项目1项、上海市卫健委临床研究专项1项等；作为主要负责人承担国家863计划1项、卫生部重点学科课题2项等。

在国内最先参与研制中国可降解涂层的药物洗脱支架，并最早发表国内研究发现，填补国内可降解药物洗脱支架领域空白。在国内率先引入“支架失败”理念和并开展系列临床技术研究，国际上首次提出“弥漫性支架扩张不良”是支架失败的重要机制，引起国际权威同行的关注，为降低PCI死亡率提供重要依据；国际上最早揭示心肌桥OCT上的特征性“FUSIFORM现象”及壁冠脉“腔小壁薄”的组织特性，为预防重大手术并发症提供临床依据。基于技术特色和优势，2013年起每年主办上海“优化PCI学术研讨会”，累计1万余人参加；举办实践培训班，吸引东南亚和全国100人次心血管医生来院进修学习，推动冠脉病变诊疗理念与技术的革新。近年来带领团队筛选和验证心梗早期预警生物标志物，完成1500余例心梗患者长期随访，同时基于QFR技术，致力探索心梗患者的个体化治疗策略。

出版专著：

《血管内超声（第二版）》              副主编       人民卫生出版社,2018

《2019现代心脏病学进展》             副主编       科学出版社,2019.5

《2018现代心脏病学进展》             副主编       科学出版社,2018.5

《血管内超声中国专家共识》          主笔编者    中华心血管病杂志,2018.5

《2017现代心脏病学进展》             副主编       科学出版社,2017.5

《OCT中国专家共识》                     编者          中华心血管病杂志,2017.1

《2016现代心脏病学进展》             副主编       科学出版社,2016.5

《OCT临床应用进展》                     副主编       科学技术出版社,2015

《冠状动脉疾病影像学》                  副主编       北京大学医学出版社,2015

《2015现代心脏病学进展》              副主编       科学出版社,2015

《2014现代心脏病学进展》              副主编       复旦大学出版社,2014

《现代心脏病学》                            主编助理    复旦大学出版社,2011

《实用内科学（第13版）》              编者           人民卫生出版社,2009

《冠状动脉慢性闭塞病变介入治疗》编者          人民卫生出版社,2009

《内科学》八年制英文教材              编者           人民卫生出版社,2007

《实用心脏病学（第4版）》            编者           上海科技出版社,2007

《Handbook of Complications duringPercutaneous Coronary Interventions》 

编者       CRC Press出版社,2006

科技奖项：

2010年 上海市科学技术奖一等奖

2009年 上海市科学技术进步一等奖

2009年 教育部科学技术进步奖一等奖

2009年 中华医学科技奖三等奖

2005年 上海市科学技术进步一等奖

论文：

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2.     Hao Lin , Tongqing Yao , Haoran Ding , Jiapeng Chu , DeqiangYuan , Fan Ping , Fei Chen, Xuebo Liu. Identification and functionalcharacterization of differentially expressed circRNAs in high glucose treatedendothelial cells: Construction of circRNA-miRNA-mRNA network. Heliyon.2024;10(17)

3.     Feng, Yuntao; Lin, Hao; Tan, Hongwei; Liu, Xuebo. Life'sessential 8 metrics and mortality outcomes in insulin resistance: The role ofinflammation, vascular aging, and gender. Clinical nutrition ESPEN.2024 Jun 61卷 131-139页

4.     Ding, Haoran; Tong, Jing; Lin, Hao; Ping, Fan; Yao, Tongqing;Ye, Zi; Chu, Jiapeng; Yuan, Deqiang; Wang, Kangwei; Liu, Xuebo; Chen, Fei. KLF4inhibited the senescence-associated secretory phenotype in ox-LDL-treatedendothelial cells via PDGFRA/NAMPT/mitochondrial ROS.Aging.2024 May 8 16卷 9期 8070-8085页

5.     Yuntao Feng, Hao Lin, Hongwei Tan, Xuebo Liu. Heterogeneity ofaging and mortality risk among individuals with hypertension: Insights fromphenotypic age and phenotypic age acceleration. JOURNAL OF NUTRITION HEALTH& AGING.2024 Mar 8 28卷 5期 100203页

6.     Jiapeng Chu, Yan Lai, Yian Yao, Wen Ye, Tongqing Yao, Hao Lin,Deqiang Yuan, Fan Ping, Guoqi Zhu,Haoran Ding, Fei Chen, Wenwen Yan, Xuebo Liu.The Relationship Between Glycemic Risk and Longitudinal Changes in TotalPhysiological Atherosclerotic Burden in Patients with Coronary Artery Disease.  Quant Imaging Med Surg.Jan 17, 2024

7.     Jiapeng Chu, Deqiang Yuan, Yan Lai,Wen Ye, Lei Liu, Hao Lin, FanPing,Guoqi Zhu, Fei Chen,Yian Yao, Wenwen Yan and Xuebo Liu. PrognosticImplications of Changes in Total Physiological Atherosclerotic Burden inPatients With Coronary Artery Disease—A Serial QFR Study. Angiology.2023 Nov23   Vol. 0(0) 1–9

8.     Ji, Bing; Yao, Tongqing; Tong, Jing; Ye, Zi; Ping, Fan; Chen,Fei; Liu, Xue-Bo. Impact of percutaneous coronary intervention on renalfunction in patients with coronary heart disease. Archivio Monaldi per lemalattie del torace.2023 Nov 2

9.     Hao Lin, Jiapeng Chu, DeqiangYuan, Kangwei Wang, Fei Chen, XueboLiu.MiR-206 may regulate mitochondrial ROScontribute to the progression ofMyocardial infarction via TREM1.BMCCardiovascular Disorders.(2023) 23:470

10.  Haoran Ding, Guoqi Zhu, HaoLin, Jiapeng Chu, Deqiang Yuan, Yi’anYao, Yanhua Gao, Fei Chen, Xuebo Liu. Screeningof Potential CirculatingDiagnostic Biomarkers and Molecular Mechanisms ofSystemic LupusErythematosus-Related Myocardial Infarction by IntegrativeAnalysis.Journal ofInflammation Research.2023;16：3119-3134 

11.  Haoran Ding, Guoqi Zhu, HaoLin, Jiapeng Chu, Deqiang Yuan, Yi’anYao, Yanhua Gao, Fei Chen, Xuebo Liu. ComprehensiveAnalysis of AtheroscleroticPlaques Reveals Crucial Genes and MolecularMechanisms Associated with Plaqueprogression and Rupture.Front Cardiovasc Med.28March 2023;10

12.  Jian-ming Wei, Yan-li Song,Huan Zeng, Wen-wen Yan, Xue-bo Liu.Assessing causality between different riskfactors and pulmonary embolism: AMendelian randomization study.FRONTIERS INCARDIOVASCULAR MEDICINE.FEB 23 2023；10卷

13.  Jiapeng Chu, Yan Lai, WenwenYan, Yian Yao, Hao Lin, DeqiangYuan, Fan Ping,Guoqi Zhu, Zi Ye, Tongqing Yao,Fei Chen, Xuebo Liu. Impact ofRadial Wall Strain on Serial Changes in VascularPhysiology in Patients withIntermediate Coronary Stenosis.Rev. Cardiovasc. Med.2023;24(8): 245

14.  Deqiang Yuan, Jiapeng Chu,Hao Lin, Guoqi Zhu, Jun Qian,Yunan Yu,Tongqing Yao, Fan Ping, Fei Chen, XueboLiu. Mechanism of homocysteine-mediatedendothelial injury and its consequencesfor atherosclerosis.FRONTIERS INCARDIOVASCULAR MEDICINE.JAN 16 2023； 9卷

15.  Jiapeng Chu, Hao Lin, WenwenYan, Deqiang Yuan, Yan Lai, XueboLiu. Angiographic Quantitative Flow Ratio inAcute Coronary Syndrome: Beyond aTool to Define Ischemia-causing Stenosis – A.CardiovascularDiagnosis andTherapy.2022;12(6):892-907

16.  Hong-Wei Tan, Wei-Dong Gao,Xin-Hua Wang, Zhi-Song Chen,Xue-BoLiu. A Four-Stepwise ElectrocardiographicAlgorithm for Differentiation ofVentricular Arrhythmias Originated from LeftVentricular Outflow Tract. Journalof clinical medicine.2022.10

17.  Jun Qian, Yanhua Gao, YanLai, Zi Ye, Yian Yao, Keke Ding, JingTong, Hao Lin ,Guoqi Zhu, Yunan Yu,Haoran Ding, Deqiang Yuan, Jiapeng Chu,FeiChen, Xuebo Liu. Single-cell RNAsequencing of peripheral blood mononuclearcells from acute myocardialinfarction.Frontiers in Immunology-Inflammation.2022

18.  Jing Tong, Bing Ji, Yan-Hua Gao, Hao Lin, Fan Ping, FeiChen,Xue-Bo Liu. Sirt6 regulates autophagy in AGE-treated endothelial cells viaKLF4.Nutrition,metabolism and cardiovascular diseases.2022.03；32.755-764

19.  Guoqi Zhu , Yan Lai, Fei Chen, Jun Qian, Hao Lin, DeqiangYuan,Tongqing Yao,and XueBo Liu. Exploration of the Crucial Genes andMolecularMechanisms Mediating Atherosclerosis and Abnormal Endothelial ShearStress. DISEASEMARKERS.2022-08-12卷2022；页6306845

20.  Jiani Tang,Hanjing Hou ,JiapengChu,Fei Chen,Yian Yao,YanhuaGao,ZiYe,Shaowei Zhuang ,Yan Lai,Xuebo Liu. Clinicalimplication ofquantitativeflow ratio to predict clinical events afterdrug-coated balloonangioplasty inpatients with in-stent restenosis. ClinCardiol. 2021Jul;44(7):978-986.

21.  Hongwei Tan,ZhisongChen,FeiChen,Wenjun Xu,Xuebo Liu. CKAP4participates in tryptase-inducedphenotypicconversion in atrial fibroblaststhrough PAR2/p38/JNK pathway. Am JTransl Res.2021;13(4):2270-2282.

22.  Zhi-Song Chen,Hong-WeiTan,Hao-Ming Song, Wen-Jun Xu,Xue-Bo Liu.Impact of corrected sinusnoderecovery time in predicting recurrence in patientswith paroxysmalatrialfibrillation. J Int Med Res. 2021 May;49(5).

23.  Jun Qian,Jiyong Zan,LijunKuang,LinChe,Yunan Yu,Ting Shen, JianiTang,Fei Chen,Xuebo Liu. A predictivenomogram ofbleeding risk in patients withatrial fibrillation afterdrug-eluting stentimplantation. Ann Transl Med.2021.02;20:3971；VOL9,NO3.

24.  Jiani Tang,Jiapeng Chu,HanjingHou,YanLai,Shengxian,Fei Chen,YianYao,Zi Ye1,Yanhua Gao,Yu Mao,ShaoweiZhuang,XueboLiu. Clinical implication ofQFR in patients with ST-segementelevationmyocardial infarction afterdrug-eluting stent implantation. Int JCardiovascImaging. 2021Mar;37(3):755-766.

25.  Jiani Tang,YanLai,ShengxianTu,Fei Chen,Yian Yao,Zi Ye,JianyunGu,Yanhua Gao,ChunyuGuan,Jiapeng Chu,ChengYang,Xuebo Liu. Quantitative FlowRatio guided ResidualFunctional SYNTAX Scorefor Risk Assessment in Patientswith ST-Segment ElevationMyocardial Infarctionundergoing Percutaneous CoronaryIntervention.Eurointervention. 2021 Jul20;17(4):e287-e293.

26.  Jun Qian,Lijun Kuang, LinChe,Fei Chen, Xuebo Liu. Maximum bloodglucose levels during hospitalisationtopredict mortality in patients with acutecoronary syndrome: aretrospectivecohort study. BMJ Open. 2020 Dec 12;1012(12).

27.  Jiapeng Chu,Jiani Tang,YanLai,Yanhua Gao, Zi Ye, Chunyu Guan,Keke Ding, Yian Yao, Fei Chen,Xuebo Liu.Associationof Stress HyperglycemiaRatio with Intracoronary Thrombus Burden inDiabeticPatients with ST-segmentElevation Myocardial Infarction. Journal ofThoracicDisease. 2020Nov;1211(11);6598-6608.

28.  Yun Kai Wang,Jia Ni Tang,LuHan,XianDong Liu,Yun Li Shen,Chun YuZhang, Xue Bo Liu. Elevated FURIN levelsinpredicting mortality andcardiovascular events in patients withacutemyocardial infarction. Metabolism.Volume 111, October 2020, 154323.

29.  Jie Zhang,JiaqiWang,HanYu,Guanghua Wang,Junfang Zhang,RuiZhu,Xuebo Liu,Jue Li. ComparisonBetweenAtorvastatin and Rosuvastatin onSecondary Percutaneous CoronaryInterventionRate and the Risk Factors inPatients with Coronary Heart Disease.Curr. DrugMetab. 2020;2110(10).

30.  Ye Zi,Yao Yi-An,JiBing,LaiYan,Tong Jing,Guan Chun-Yu,PingFan,Lin Hao,Tang Jia-Ni, HouHan-Jin,ChenFei,Liu Xue-Bo. Sirt6-induced autophagyrestricted TREM-1-mediatedpyroptosisin ox-LDL-treated endothelial cells:relevance to prognostication ofpatientswith acute myocardial infarction. CellDeath Discovery. ( 2019)5 :88.

31.  Zi Ye,Yan Lai,Yian Yao,GaryS.Mintz,Xuebo Liu .Optical coherencetomography and intravascularultrasoundassessment of the anatomic size and wallthickness of a muscle bridgesegment.Catheter Cardiovasc Interv. 2019.2.21;1-7.

32.  Yun Kai Wang,Jia Ni Tang,JunBoGe,Xue Bo Liu,et al. PrognosticUtility of sTREM-1 in Predicting MortalityandCardiovascular Events in Patientswith Acute Myocardial Infarction. J AMHeartAssoc. 2018.6.19;7(12):e008985.

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35.  Xiaodong Wang,YanLai,YuLuo,Xumin Zhang,Hua Zhou,Zi Ye, JianiTang,Xuebo Liu. Relationshipbetweenclopidogrel‑related polymorphisms andvariableplatelet reactivity at 1year: A cohort study from Han Chinese. J ResMed Sci.2016; 21: 111.

36.  Yu Luo,Jimin Li,XuLiu,JianfengXu,Zi Ye,Yian Yao,Xuebo Liu,YanLai. Combination of P2Y12 reactionunit andpercentage of platelet inhibitionassessed by VerifyNow P2Y12 assay isa usefulpredictor of long-term clinicaloutcomes in patients with acutecoronarysyndrome undergoing percutaneouscoronary intervention. Thromb. Res.2016Mar;139：114-120.

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