研究团队主要基于临床样本和灵长类大动物模型，进行宿主的抗结核感染免疫保护机制以及新型结核病疫苗研究，研发针对结核病尤其是耐多药结核病的细胞治疗以及免疫辅助治疗新策略。相关研究成果已经在PNAS, Angew Chem Int Ed Engl, Immunol Rev, Emerg Microbes Infect.，J Infect Dis., Cell Mol Immunol., J Immunol.等主流学术杂志发表第一或通讯作者论文60余篇, 申请专利4项，其中2项获得授权。获得包括国家自然科学基金、国家重点研发计划、美国NIH基金、中国科学院基础研究基金、上海市科委基础研究基金、上海自然科学基金以及国家和上海市博士后基金等20余项资助。

1. Shen H, Yang E, Guo M, Yang R, Huang G, Peng Y, Sha W, Wang F, Shen L. Adjunctive Zoledronate + IL-2 administrations enhance anti-tuberculosis Vγ2Vδ2 T-effector populations, and improve treatment outcome of multidrug-resistant tuberculosis. Emerg Microbes Infect. 2022 Dec;11(1):1790-1805. 

2. Shanshan Liang, Guixian Huang, Tian Wu, Ying Peng, Xi Liu, Xuejiao Ji, Wei Sha, Ling Shen, Hongbo Shen(通讯作者), MIR-337-3p enhances mycobacterial pathogenicity involving TLR4/MyD88 and STAT3 signals,imparing VDR antimicrobial response and fast-acting immunity. Front Immunol. 2021; 12:739219.

3. Wang F, Huang G, Shen L, Peng Y, Sha W, Chen ZW, Shen H (通讯作者),. Genetics and Functional Mechanisms of STAT3 Polymorphisms in Human Tuberculosis. Front Cell Infect Microbiol. 2021 Jul 7;11:669394.

4. Yang R, Peng Y, Pi J, Liu Y, Yang E, Shen X, Yao L, Shen L, Modlin RL, Shen H (并列通讯), Sha W, Chen ZW. A CD4+CD161+ T-Cell Subset Present in Unexposed Humans, Not Tb Patients, Are Fast Acting Cells That Inhibit the Growth of Intracellular Mycobacteria Involving CD161 Pathway, Perforin, and IFN-γ/Autophagy. Front Immunol. 2021 Feb 26;12:599641.

5. Shen L, Huang D, Qaqish A, Frencher J, Yang R,  Shen H (通讯作者), Chen ZW. Fast-acting γδ T-cell subpopulation and protective immunity against infections. Immunol Rev. 2020 Nov;298(1):254-263.

6. Pi J, Shen L, Yang E, Shen H (并列通讯), Huang D, Wang R, Hu C, Jin H, Cai H, Cai J, Zeng G, Chen ZW. Macrophage-Targeted Isoniazid-Selenium Nanoparticles Promote Antimicrobial Immunity and Synergize Bactericidal Destruction of Tuberculosis Bacilli. Angew Chem Int Ed Engl. 2020 ;59(8):3226-3234.

7. Pi J, Shen L, Shen H (并列通讯), Yang E, Wang W, Wang R, Huang D, Lee BS, Hu C, Chen C, Jin H, Cai J, Zeng G, Chen ZW. Mannosylated graphene oxide as macrophage-targeted delivery system for enhanced intracellular M.tuberculosis killing efficiency. Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109777.

8. Yang R, Yao L, Shen L, Sha W, Modlin RL, Shen H (通讯作者), Chen ZW. IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth. Front Immunol. 2019 Apr 26;10:913.

9. Shen L, Frencher J, Huang D, Wang W, Yang E, Chen CY, Zhang Z, Wang R, Qaqish A, Larsen MH, Shen H (并列通讯), Porcelli SA, Jacobs WR Jr, Chen ZW. Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6371-6378.

10. Yang E, Yang R, Guo M, Huang D, Wang W, Zhang Z, Chen C, Wang F, Ho W, Shen L, Xiao H, Chen ZW, Shen H (通讯作者),. Multidrug-resistant tuberculosis (MDR-TB) strain infection in macaques results in high bacilli burdens in airways, driving broad innate/adaptive immune responses. Emerg Microbes Infect. 2018 Dec 12;7(1):207.