(1)APOA4介导的胆固醇代谢在微塑料影响孕鼠胚胎生长发育中的机制研究,主持，2023年1月-2025年12月，30万，国家自然科学基金（青年）

(2)微塑料暴露对胎盘发育及胎儿宫内生长的影响机制研究,共同主持，2022年7月-2024年6月，10万，上海市母胎医学重点实验室

(3)基于PPAR代谢通路介导的胆固醇代谢在微塑料暴露对胎盘发育及胎儿宫内生长影响中的机制研究,主持，2023年1月-2025年12月，35万，同济大学附属第一妇婴保健院

(4)基于基因型和临床表型关联度算法加速外显子测序数据分析的方法研究,主持，2021年10月-2022年4月，5万，同济大学附属第一妇婴保健院

(5)儿童罕见病队列数据库及共享平台建设与应用，参与，2020年12月-2022年9月，19.5万，上海市申康医院发展中心

(6) 国家重点研发计划二级子课题,  重大胎儿疾病宫内诊断和干预相关因素初探, 2018年07月 - 2021年12月, 80万元, 结题, 参与,科技部

代表性论文：

Representative publications:

1) He, J., Xiong, S., Zhou, W., Qiu, H., Rao, Y., Liu, Y., Shen, G.,Zhao, P., Chen, G., & Li, J.Long-term polystyrene nanoparticles exposure reduces electroretinal responsesand exacerbates retinal degeneration induced by light exposure. Journal of hazardous materials，2024，, 473, 134586. Advance online publication. DOI:10.1016/j.jhazmat.2024.134586, (IF:13.6，中科院1区，共同通讯，塑料暴露导致成年鼠视网膜损伤)

2) Xiong S, He J, Qiu H, van Gestel C A M, He E, Qiao Z, Cao L, Li,& Chen Guangquan. Maternalexposure to polystyrene nanoplastics causes defective retinal development andfunction in progeny mice by disturbing metabolic profiles. Chemosphere 2024, 352:141513https://doi.org/10.1016/j.chemosphere.2024.141513 (IF:8.8，中科院2区，共通第一，母体纳米塑料暴露导致子代视网膜损伤)

3) Chen Guangquan, Shan H, Xiong S, et al. Polystyrene nanoparticleexposure accelerates ovarian cancer development in mice by altering the tumormicroenvironment. Science of the TotalEnvironment 2024, 906:167592. https://doi.org/10.1016/j.scitotenv.2023.167592 (IF:9.8，中科院1区，共一兼共通，纳米塑料通过改变肿瘤微环境促进卵巢癌生长)

4) Chen Guangquan, Xiong S, Jing Q, et al. Maternal exposure to polystyrene nanoparticles retarded fetalgrowth and triggered metabolic disorders of placenta and fetus in mice. Science of the Total Environment 2023, 854:158666 https://doi.org/10.1016/j.scitotenv.2022.158666(IF:9.8，中科院1区，第一作者，母体纳米塑料暴露导致子鼠宫内生长受限)

5）Chen Guangquan, van Straalen N M, Roelofs D. Theecotoxicogenomic assessment of soil toxicity associated with the productionchain of 2, 5- furandicarboxylic acid (FDCA), a candidate bio-based greenchemical building block. Green Chemistry2016, 18(16):4420-4431 https://doi.org/10.1039/C6GC00430J（IF：9.8，中科院1区, 第一作者，绿色塑化剂的毒性分子机制解析）

6）Chen Guangquan, den Braver M W, van Gestel C A, etal. Ecotoxicogenomic assessment of diclofenac toxicity in soil. Environmental Pollution 2015, 199(C):253-260 https://doi.org/10.1016/j.envpol.2015.01.032 （IF：8.9，中科院2区, 第一作者，双氯芬酸钠的毒性分子机制解析）

7）Zhang M, Wang Y, Xu S, Huang S, Wu M, Chen Gugnquan, & Wang, Y.Endoplasmic Reticulum Stress-Related Ten-Biomarker Risk Classifier for SurvivalEvaluation in Epithelial Ovarian Cancer and TRPM2: A Potential TherapeuticTarget of Ovarian Cancer. Internationaljournal of molecular sciences 2023,24(18):14010. https://doi.org/10.3390/ijms241814010 (IF:5.9，中科院2区，共通第二，临床统计、生物信息分析肿瘤分子标记与临床表型的关联)

8）Chen Guangquan, de Boer T E, Wagelmans M, et al.Integrating transcriptomics into triad-based soil-quality assessment. Environmental toxicology and chemistry 2014, 33(4):900-909. https://doi.org/10.1002/etc.2508 （IF：4.1，中科院3区，第一作者，环境中混合污染物毒性分子机制解析）

9）Qiao J, Chen Y, Lu Y, Wang T, Li X, Qin W, Li A, Chen Guangquan. A Syndrome of VariableAllergy, Short Stature, and Fatty Liver. Frontiersin Genetics 2022, 12:784135 https://doi.org/10.3389/fgene.2021.784135 （IF：3.7，中科院3区，共通第二，先天性遗传病分子诊断）

10）Xi Y*, Chen Guangquan*, Lei C, et al. Expandedcarrier screening in Chinese patients seeking the help of assisted reproductivetechnology. Molecular genetics &Genomic medicine 2020,8(9):e1340 https://doi.org/10.1002/mgg3.1340 （IF：2.5，中科院3区，共一第二，出生缺陷遗传病携带者筛查临床队列研究）

11）Chen Guangquan*, Xiong S*, Zou G, et al. A 6.3 Mbmaternally derived microduplication of 20p13p12.2 in a fetus with Brachydactylytype D and related literature review. Molecular Cytogenetics 2022, 15(1):6 https://doi.org/10.1186/s13039-022-00584-3（IF：1.5，中科院3区，共一第一，出生缺陷遗传罕见病分子诊断）

12）Swart E, de Boer T E, Chen Guangquan, et al. Species-specific transcriptomic responsesin Daphnia magna exposed to a bio-plastic production intermediate. Environmental Pollution 2019, 252(Pt A):399-408 https://doi.org/10.1016/j.envpol.2019.05.057 （IF：8.9，中科院2区，其他作者）

13）Ji H, Chen J, Huang P, Feng Z, Hu W, Dai M, Sun X,Jin X, Chen, Guangquan, et al,.Multi-omics analyses of G6PD deficiency variants in Chinese population. Journal of genetics and genomics = Yi chuan xue bao 2023, 51(1):100–104. https://doi.org/10.1016/j.jgg.2023.08.008(IF:5.9，中科院2区，其他作者)

14）Luo X, Wang Y, Zhang H, Chen Guangquan, et al. Identification of a Prognostic Signature forOvarian Cancer Based on Ubiquitin-Related Genes Suggesting a Potential Role forFBXO9. Biomolecules 2023, 13(12):1724. https://doi.org/10.3390/biom13121724 (IF:5.5，中科院2区，其他作者)

15）Kong L, Li S, Zhao Z, Feng J, Chen Guangquan, et al. Haplotype-Based Noninvasive PrenatalDiagnosis of 21 Families With Duchenne Muscular Dystrophy: Real-World ClinicalData in China. Frontiers in Genetics 2021, 12:791856 https://doi.org/10.3389/fgene.2021.791856 （IF：4.8，中科院3区，其他作者）

16）Zhu D, Wei X, ChenGuangquan, et al. Chromosomal abnormalities in recurrent pregnancy loss andits association with clinical characteristics. Journal of Assisted Reproduction and Genetics 2023, 40(7):1713-1720. https://doi.org/10.1007/s10815-023-02816-w（IF：3.1，中科院3区，其他作者）

17）Xiong S, Wu F, Chen Guangquan, et al. Prenatal Phenotypical Discrepancy inMonozygotic Twins with Tuberous Sclerosis Complex. Maternal-Fetal Medicine 2022,4(04):286-289. https://mednexus.org/doi/full/10.1097/FM9.0000000000000109（IF：1.2，中科院4区，其他作者）

18）Hao Qiu, Jingjing Li, Guangquan Chen, et al, Penetration ofmicro/nanoplastics into biological barriers in organisms and associated healtheffects, Chinese Science Bulletin, 微/纳塑料穿透机体生物屏障及其健康效应，科学通报 2023, 69(6):717-730, https://doi.org/10.1360/TB-2023-0295（IF：1.0，中文核心，其他作者）