本课题组专注于原发性干燥综合征和代谢性炎症的基础与临床研究，探究干燥综合征的发病机制及早期诊治方法。建立了包括1000余例初诊pSS的完整生物样本库及病情随访信息化平台以开展基础与临床研究。相关工作尝试对中国干燥综合征不同脏器受累的群体画像进行描绘；提出了原发性干燥综合征新的发病机制、早期诊断标记和治疗新方法；在多个风湿病不良预后风险模型的预测上取得了一定成果，部分研究被Hepatology、Frontier in immunology、RMD open等杂志引用，相关成果多次参加欧洲风湿病联盟、美国风湿病协会、中华医学会风湿病学分会的发言交流。

长期从事“炎症与免疫”领域研究工作，专注于免疫病发病机制和早期诊治方法的探索。相关领域获得包括国家自然科学基金、上海市科委医学创新研究项目等课题的资助，入选上海市青年科技英才扬帆计划、上海市“医苑新星”青年医学人才培养计划、中央高校基础研究人才计划、同济大学优青计划、同济医院优秀人才计划“甘泉新星”等人才计划。

主持包括国家自然科学基金、上海市科委、上海市卫健委等各级各类课题及人才计划10余项，部分如下：

1. 国家自然科学基金青年项目，项目编号81801601，循环miR-30c调控I型干扰素信号参与干燥综合征发病的机制研究；

2 上海市科委医学创新研究项目，编号20Y11911600，血浆外泌体miR29作为干燥综合征合并间质性肺病分子标记物的应用研究；

3 上海市青年科技英才扬帆计划项目，项目编号17YF1417200，循环microRNA在干燥综合征诊断和病程中的作用及其机制研究；

4 上海市“医苑新星”青年医学人才培养资助计划， 2020.04至2023.04，被评为优秀结业学员；

5 中央高校基本科研业务费专项基金基础研究人才培养计划，编号22120170199，循环miR30c在干燥综合征诊断和病程中的作用及其机制研究。

以第一或通讯作者发表SCI论文20余篇，中文核心期刊6篇，获批专利4项。部分成果如下：

1.    Yang L#, Pu J#, CaiF, Zhang Y, Gao R, Zhuang S, Liang Y, Wu Z, Pan S, Song J, Han F, Tang J*, WangX*. Chronic Epstein-Barr virus infection: A potential junction between primary Sjögren's syndrome and lymphoma, Cytokine, 2023, 168:156227. (通讯作者)

2.    Gao R, Pu J, Wu Z,Tang J, Wang X*. Osteoarthritis or arthritis? Toward understanding of primary Sjögren's syndrome patients with arthralgia, J Orthop Surg Res, 2023, 18(1):41.(通讯作者,)

3.    Pu J#, Song J#, PanS, Zhuang S, Gao R, Liang Y, Wu Z, Wang Y, Zhang Y, Yang L, Han F, Wu H, Tang J*,Wang X*. Predicting cardiovascular risk in a Chinese primary Sjögren'ssyndrome population: development and assessment of a predictive nomogram, TherAdv Chronic Dis, 2023, 14:20406223231181490. (通讯作者)

4.    Chen S#, Wang X#,Sun C, Zhao CB, Lin J*. MAGT1 Gene Mutation is Associated with Myositis and CD127 Expression Downregulation. J Clin Immunol. 2022. (共同第一作者)

5.    Gao R#, Wu Z#, Xu X#,Pu J, Pan S, Zhang Y, Zhuang S, Yang L, Liang Y, Song J, Tang J*, Wang X*. Predictors of poor prognosis in ANCA-associated vasculitis (AAV): a single-center prospective study of inpatients in China, Clin Exp Med, 2022. (通讯作者)

6.    Zhuang S#, Pu J#, Liang Y, Wu Z, Gao R, Pan S, Song J, Tang J*, Wang X*. Potential Mechanisms of White Peony against Primary Sjögren's Syndrome Based on Network Pharmacology and MolecularDocking, Evid Based Complement Alternat Med, 2022, 2022:5507472. (通讯作者)

7.    Li B, Yan J, Pu J,Tang J, Xu S*, Wang X*. A Response to: Letter to the Editor Regarding[Esophageal Dysfunction and Systemic Sclerosis: Drugs Should be Kept in Mind],Rheumatol Ther, 2022, 9(4):1241-1243. (通讯作者)

8.    Zhang Y, Zhang L, WuZ, Tang J*, Wang X*. Relapsing Polychondritis Associated with Miscellaneous Ocular Symptoms and Increased IgA: a Case Report, Iran JImmunol, 2022, 19(1):10. (通讯作者)

9.    Li B, Yan J, Pu J,Tang J, Xu S*, Wang X*. Esophageal Dysfunction in Systemic Sclerosis: AnUpdate, RHEUMATOLOGY AND THERAPY, 2021,8(4):1535-1549. (通讯作者)

10.  Gao R#, Xu X#, WangS#, Pu J, Shi C, Wen S, Zhu Y, Tang J, Wang X*, Yu L*. The efficacy of gabapentin for the treatment of refractory cough associated with interstitial lung disease: study protocol for a randomized, double-blind and placebo-controlled clinical trial, Trials, 2022, 23(1):165. (通讯作者)

11.  Pu J#, Wang X#,Riaz F, Zhang T, Gao R, Pan S, Wu Z, Liang Y, Zhuang S, Tang J*. Effectiveness and Safety of Iguratimod in Treating Primary Sjögren's Syndrome: A Systematic Review and Meta-Analysis. Front Pharmacol. 2021,12:621208. (共同第一作者)

12.  Wang X#, Zhang T#, Guo Z, Pu J, Riaz F, Feng R,Fang X, Song J, Liang Y, Wu Z, Pan S, Tang J*. The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren's Syndrome: A Systematic Review and Meta-Analysis. Front Pharmacol. 2021,12:693796. (第一作者)

13.  Wang X, Wu Z, Pu J, Feng R, Tang J*. TheDLEU2/miR-15a/16-1 Cluster Inhibit Foxp3+Treg Cells in Salivary Glands of pSSvia Targeting Foxp3, ARTHRITIS & RHEUMATOLOGY, 2019, 71. (第一作者)

14.  Yao Q#, Wang X#,He W, Song Z, Wang B, Zhang J*, Qin Q*. Circulating microRNA-144-3p and miR-762are novel biomarkers of Graves' disease, Endocrine, 2019, 65(1):102-109. (共同第一作者)

15.  Wang X, Shao X, Liu X, Qin Q, Xu J, Zhang JA*. DysregulatedInterleukin-33/ST2 Pathway Perpetuates Chronic Inflammation in Hashimoto'sThyroiditis, Endocr Metab Immune Disord Drug Targets.2019, 19(7):1012-1021. (第一作者)

16.  Wang X, Zhu Y, Li D, Qin Q, Wang Q, Muhali FS,Jiang WJ, Zhang JA*. Polymorphisms of ST2-IL18R1-IL18RAP gene cluster: a new risk for autoimmune thyroid diseases, International Journal of Immunogenetics.2016, 43(1):18-24. (第一作者)

17.  Wang X, Wang M, Li H, Lan X, Liu L, Li J, Li Y, LiJ, Yi J, Du X, Yan J, Han Y, Zhang F, Liu M, Lu S, Li D*. Upregulation of miR-497 induces hepatic insulin resistance in E3 rats with HFD-MetS by targeting insulin receptor, Molecular and Cellular Endocrinology. 2015,416(C):57-69. (第一作者)

18.  Li D#, Wang X#,Lan X, Li Y, Liu L, Yi J, Li J, Sun Q, Wang Y, Li H, Zhong N, Holmdahl R, Lu S*.Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats, Molecular and Cellular Endocrinology. 2015, 402(C):1-12. (共同第一作者)

19.  Li D#, Wang X#,Ren W, Ren J, Lan X, WangF, Li H, Zhang F, Han Y, Song T, Holmdahl R, Lu S*. High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-gamma and LXR-alpha-pathways in E3 rats, Molecular and Cellular Endocrinology. 2011, 344(1-2):69-80. (共同第一作者)