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2009年9月毕业于北京师范大学,获学士学位。2012年7月毕业于北京师范大学,获细胞生物学硕士学位。2017年7月毕业于浙江大学,获得免疫学博士学位,博士期间主要研究表观遗传机制在机体抗病毒的免疫反应中的调节作用。2017年8月至2020年8月在中国医学科学院北京协和医学院从事博士后研究。主要研究方向为炎症反应中的表观修饰机制和代谢调控机制。2020年11月起受聘于同济大学生命科学与技术学院。学术成果在Cell、Trends in Immunology、Science Advances、Journal of Clinical Investigation、Advanced Science、eBiomedicine、Journal of Autoimmunity等期刊发表。已有两项国家发明专利获授权。主持多个国家级和省部级科研项目。担任国际学术期刊Pharmacological Research (IF=10.5)顾问编辑。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg1. Jing J#, Yang F#, Wang K#, Cui M, Kong N, Wang S, Qiao X, Kong F, Zhao D, Ji J, Tang L, Gao J, Cong YS, Ding D, Chen K*. UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation. Adv Sci. e2406786. (2025)
2. Chen K*, Cao X*. Biomolecular condensates: phasing in regulated host-pathogen interactions. Trends Immunol. 46(1):29-45 (2024) (Featured Review)
3. Chen Y, Chen K, Zhu H, Qin H, Liu J, Cao X*. Methyltransferase Setd2 prevents T cell-mediated autoimmune diseases via phospholipid remodeling. Proc Natl Acad Sci U S A. 121(8): e2314561121. (2024).
4.Xiong H#, Cui M#, Kong N#, Jing J, Xu Y, Liu X, Yang F, Xu Z, Yan Y, Zhao D, Zou Z, Xia M, Cen J, Tan G, Huai C, Fu Q, Guo Q, Chen K*, Cytotoxic CD161-CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus, eBioMedicine, 90. (2023) (同期亮点评述)
5.Chen K, Liu J, Liu S, Xia M, Zhang X, Han D, Jiang Y, Wang C, Cao X. Methyltransferase SETD2-mediated methylation of STAT1 is critical for interferon antiviral activity. Cell, 170(3): 492-506. (2017). (受到Cell Research亮点评述、F1000推荐,被评选为2017年度Cell出版社中国区年度论文)
6.Chen Y, Liu J, Zhang X, hu H, Wang Y, Li Z, Liu Y, Liu S, Liu S, Li N, Chen K*, Cao X*, lncRNA-GM targets Foxo1 to promote T cell–mediated autoimmunity, Science Advances, 8(31). (2022)
7.Jiang K#, Tu Z#, Chen K#, Xu Y, Chen F, Xu S, Shi T, Qian J, Shen L, Hwa J, Wang D, Xiang Y, Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction, The Journal of Clinical Investigation, 132(1). (2022)
8.Chen K, Liu J and Cao X. cGAS-STING pathway in senescence-related inflammation. Natl. Sci.Rev., 5(3): 308-310. (2018).
9.Zhu H, Chen K, Chen Y, Liu J, Zhang X, Zhou, Y Liu Q, Wang B, Chen T, Cao X, RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis, Signal Transduction and Targeted Therapy, 7(1). (2022)
10.Chen K, Liu J and Cao X. Regulation of type I interferon signaling in immunity and inflammation:a comprehensive review. J. Autoimmun., pii: S0896-8411(17)30189-0 (2017).
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