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2015年博士毕业于复旦大学,2015年至2020年在美国北卡大学从事博士后研究,2020年2月起受聘于同济大学,任特聘研究员。以通讯或第一作者在MolecularCell、JCI、ScienceAdvances、PNAS等杂志发表研究论文十余篇,入选上海海外高层次人才、东方学者、浦江人才。
代表论文(#Co-first author, *Co-corresponding author):
1. Lin, M., He, J., Zhang, X.,Sun, X., Dong, W., Zhang, R., Xu, Y.*,and Lv, L.* (2023). Targeting fibrinogen-like protein 1 enhances immunotherapyin hepatocellular carcinoma. J Clin Invest 133. (Previewed by JCI, Editor’spicks)
2. Zhang, R., Yang, Y., Dong, W.,Lin, M., He, J., Zhang, X., Tian, T., Yang, Y., Chen, K., Lei, Q.Y., Zhang, S.*,Xu, Y.*, and Lv, L.* (2022).D-mannose facilitates immunotherapy and radiotherapy of triple-negative breastcancer via degradation of PD-L1. Proc Natl Acad Sci U S A 119. (ESI Highly cited paper)
3. Zhang, X., Li, S., He, J., Jin,Y., Zhang, R., Dong, W., Lin, M., Yang, Y., Tian, T., Zhou, Y., Xu, Y., Lei,Q.Y., Zhang, J., Zhang, Q., Xu, Y.*,and Lv, L.* (2022). TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal CellCarcinoma by Inhibiting HIF Signaling. Cancer Res 82, 2097-2109.
4. Chen, L.L., Smith, M.D., Lv,L., Nakagawa, T., Li, Z., Sun, S.C., Brown, N.G., Xiong, Y.*, and Xu, Y.* (2020). USP15 suppresses tumorimmunity via deubiquitylation and inactivation of TET2. Science Advances 6.
5. Xu, Y., Lv, L., Liu, Y., Smith, M.D.,Li, W.C., Tan, X.M., Cheng, M., Li, Z., Bovino, M., Aube, J., Xiong, Y.*(2019). Tumor suppressor TET2 promotes cancer immunity and immunotherapyefficacy. J Clin Invest 129, 4316-4331.
6. Lv, L.#, Wang, Q.#, Xu, Y.#, Tsao, L.C.#, Nakagawa, T.,Guo, H., Su, L.*, and Xiong, Y.* (2018). Vpr Targets TET2 for Degradation byCRL4(VprBP) E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication.Molecular Cell 70, 961-970 e965.
7. Murphy, C.M.#, Xu, Y.#, Li, F.#, Nio, K.,Reszka-Blanco, N., Li, X., Wu, Y., Yu, Y., Xiong, Y.*, and Su, L.* (2016).Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBVReplication. Cell Rep 16, 2846-2854.
8. Xu, Y., Li, F., Lv, L., Li, T., Zhou,X., Deng, C.X., Guan, K.L., Lei, Q.Y.*, and Xiong, Y.* (2014). Oxidative stressactivates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. Cancer Res 74, 3630-3642.
9. Lv, L.#, Xu, Y.#, Zhao, D., Li,F.L., Wang, W., Sasaki, N., Jiang, Y., Zhou, X., Li, T.T., Guan, K.L., Lei,Q.Y.*, and Xiong, Y.* (2013). Mitogenic and oncogenic stimulation of K433acetylation promotes PKM2 protein kinase activity and nuclear localization. Molecular Cell 52, 340-352. (Cover Story, Highlighted by Nature Reviews Cancerand Cancer Discovery)
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